Wear resistant antimicrobial compositions and methods of use

a technology of antimicrobial compositions and compositions, applied in the field of antimicrobial compositions, can solve the problems of difficult elimination, health hazards of microorganisms, and increased risk of individual microorganisms, and achieve the effect of improving wear resistan

Inactive Publication Date: 2012-06-14
ECOLAB USA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0015]The anti-microbial compositions of the invention provide a film that is long lasting with residual antimicrobial effect with improved wear resistance when applied to a surface. The compositions comprise a synergistic blend of a quaternary ammonium compound, preferably quaternary ammonium chloride, and cationic biocide such as poly-hexamethylene biguande. In preferred embodiments that compositions also include an amin

Problems solved by technology

Several such microbes/microorganisms, individually or in combination, can cause illness or other health problems, for example, when they come into contact with humans and/or animals, or when they are ingested along with food which has contacted them.
These microbes present health hazards due to infection or contamination.
Biofilms frequently consist of a number of different species of microorganisms which in turn can be more difficult to eradicate and thus more hazardous to health than individual microorganisms.
Some microorganisms also produce polysaccharide coatings, which makes them more difficult to destroy.
Without this affixing point, the reproduction of the microorganism particularly bacteria cannot proceed, or is at least seriously impaired.
Such disposable materials involve increased costs and increased waste, as well as potential safety issues associated with their disposal.
The food-preparation and delivery industry is another area in which presence of microbes (e.g., bacteria) can be problematic.
Food preparation facilitie

Method used

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  • Wear resistant antimicrobial compositions and methods of use
  • Wear resistant antimicrobial compositions and methods of use
  • Wear resistant antimicrobial compositions and methods of use

Examples

Experimental program
Comparison scheme
Effect test

example 1

Hard Surface Efficacy of PHMB / Quaternary Ammonium Chloride Blend Vs. Stabilized Chlorine Dioxide

[0176]The objective of this analysis was to examine the efficacy of various compositions against Staphylococcus aureus ATCC 6538 and Klebsiella pneumoniae ATCC 4352 after application to inanimate, non-porous, non-food contact surfaces.

Test Method:

Residual Self-Sanitizing Activity on Hard, Non-Porous Surfaces

[0177]Test Surface Preparation:[0178]Clean glass test surfaces were decontaminated by immersing in reagent alcohol and allowing to air dry at room temperature. The test surfaces were dried in sterile glass petri dishes containing 2 layers of Whatman No. 2 paper. Each petri dish had two surfaces in them and were dried for 1 day in a biological safety cabinet with the lids cracked open.

[0179]Test Surface Inoculation and Coating:[0180]The initial inoculum suspension was prepared by making 10−2 and 10−4 dilutions from a 48-54 hour broth culture of the test system. The 10−4 dilution was all...

example 2

Residual Self-Sanitizing Screen of Test Composition A

[0205]The objective of the analysis was to examine the residual self-sanitizing efficacy of against Staphylococcus aureus ATCC 6538 and Klebsiella pneumoniae ATCC 4352 after application to inanimate, non-porous, non-food contact surfaces.

Test Method:

Residual Self-Sanitizing Activity on Hard, Non-Porous Surfaces

Test System Preparation

[0206]1. At least three consecutive loop transfers of a 24 hour culture of Staphylococcus aureus ATCC 6538 and Klebsiella pneumoniae ATCC 4352 were performed in 10 mL of AOAC Synthetic broth or AOAC Nutrient broth (respectively) and incubated at 35° C.[0207]2. Initial Inoculum Suspension:

[0208]2.1 Vortex a 48-54 hour culture for 3-4 seconds.

[0209]2.2 Make two 1 / 100 dilutions in sterile PBDW and let stand for 15±1 minutes.[0210]3. Reinoculation Suspension:[0211]3.1 Vortex an 18-24 hour culture for 3-4 seconds.[0212]3.2 Make two 1 / 100 dilutions in sterile PBDW and on final dilution of 5.0 mL of diluted c...

example 3

Residual Self-Sanitizing Screen of Test Composition C

[0259]The objective of the analysis was to examine the residual self-sanitizing efficacy of Test composition C (a composition according to the invention) against Staphylococcus aureus ATCC 6538 and Klebsiella pneumoniae ATCC 4352 after application to inanimate, non-porous, non-food contact surfaces.

Test Method:

Residual Self-Sanitizing Activity on Hard, Non-Porous Surfaces

Test System Preparation

[0260]1. At least three consecutive loop transfers of a 24 hour culture of Staphylococcus aureus ATCC 6538 and Klebsiella pneumoniae ATCC 4352 were performed in 10 mL of AOAC Synthetic broth or AOAC Nutrient broth (respectively) and incubated at 35° C.[0261]2. Initial Inoculum Suspension:

[0262]2.1 Vortex a 48-54 hour culture for 3-4 seconds.

[0263]2.2 Make two 1 / 100 dilutions in sterile PBDW and let stand for 15±1 minutes.[0264]3. Reinoculation Suspension:[0265]3.1 Vortex an 18-24 hour culture for 3-4 seconds.[0266]3.2 Make two 1 / 100 dilution...

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Abstract

Anti-microbial compositions comprising (a) a quaternary ammonium compound and (b) a cationic biocide. Applicant has discovered a synergistic combination of the two components with the ration of cationic biocide to quaternary ammonium being less than 1:10 or with a single quaternary compound in a ratio of less than 1.6 to 1 provide a film forming coating that has residual anti-bacterial activity and improved durability with strong resistance to general wear between applications.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority under 35 U.S.C. §119 to provisional application Ser. No. 61 / 422,908 filed Dec. 14, 2010, herein incorporated by reference in its entirety.FIELD OF THE INVENTION[0002]This invention relates to anti-microbial compositions and use of the same to disinfect or clean various surfaces.BACKGROUND OF THE INVENTION[0003]Microbes may often be present on many common objects and surfaces in everyday life. Microbes can include, for example, bacteria, fungi, spores, viruses, prions, microorganisms such as, e.g., Mycobacterium tuberculosis, listeria monocytogenas, escherichia coli, pseudomonas aeruginosa, salmonella typhimurium, salmonella enteritidis, legionella bacteria, Yersinia pestis, staphylococcus aereus, bacillus subtilis, enterobacter aerogenes, streptococcus faecalis, legionella pneumophila, vibrio parahaemolyticus, bacillus cereus, and other gram positive and gram negative microorganisms. Several such microbes / ...

Claims

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Application Information

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IPC IPC(8): B05D5/00B05D3/10C09D5/14
CPCC09D5/14A01N33/12A01N25/30A01N47/44A01N2300/00A61P31/04A01N25/02A01N25/24A01N59/00
Inventor HERDT, BRANDONSTAUB, RICHARDTAUER, KEVINSMITH, KIM R.
Owner ECOLAB USA INC
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