Composite bone repairing material and preparation method thereof

Abstract

The invention relates to a filling stent material containing a three-layer structure and suitable for bone repairing and a preparation method of the filling stent material. The bottom end of a bone repairing stent has a multi-stage pore structure with high porosity, can slowly release bioactive factors and improve the inflammatory state of a bone lesion portion, has good biological activity and bone induction ability, and is beneficial to enhancing osteogenesis and bone remodelling; and an upper end is a bone cement matrix barrier layer with low porosity, and a middle layer is an adhesive layer. The composite stent provided by the invention utilizes a barrier effect of an upper layer and an osteogenesis promoting effect of a lower layer, and can effectively promote repairing and regeneration of bone tissues; and besides good adhesion and filling effects, the filling gel auxiliary material also has a bone growth promoting component, and has a synergistic effect with a skeleton.

Description

technical field [0001] The invention belongs to the field of orthopedic materials, in particular to a bioactive composite matrix orthopedic repair filling material with a gradient pore structure and a preparation method thereof. Background technique [0002] In orthopedic clinical practice, guided tissue regeneration using bionic bone is a commonly used bone repair method. In dental practice, tooth extraction and dental implant after tooth extraction are common operations. However, due to individual differences, alveolar bone defect or underestimation is a common situation, especially when the thickness and bone density of the alveolar socket bone are not ideal, which will seriously affect the implant effect. [0003] Therefore, it has a good application prospect to repair the bone in the alveolar region before implantation, promote the thickness and density of the alveolar bone, and overcome the defect of insufficient alveolar bone. [0004] At present, bone repair materi...

AI Technical Summary

Problems solved by technology

Although the porous calcium phosphate scaffold-loaded microsphere composite has the effect of filling bone reconstruction and osteoinductive osteogenesis, the loaded drug is not suitable for the oral environment, and it is easy to escape under the action of cavity fluid

[0010] In summary, the bone repair materials in the prior art are difficult to be effectively used in the alveolar socket of the oral cavity. The main problems are:

[0013] However, at present, bone repair materials are mainly used in the environment of closed bone defects, which are difficult to be used in the open and complex environment of the oral cavity, and there are many disadvantages: for example, the scaffold material is easily infiltrated by saliva, and the slowly released bioactive factors are easily diluted and difficult to repair. It is enriched in the osteogenic site, and it is also difficult to continuously provide other nutrients to the required bone growth tissue, which is not conducive to bone proliferation and promotes bone tissue growth

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