Preparation method of isobutyramide

Abstract

The invention relates to a preparation method of isobutyramide. The method comprises the following steps: conducting a hydration reaction of isobutyronitrile and de-ionized water, which serve as raw materials, under the action of a nitrile hydratase catalyst so as to obtain isobutyramide, and conducting simple treatment on an obtained isobutyramide water solution so as to obtain a high-purity isobutyramide crystal product. According to the preparation method provided by the invention, the high-purity isobutyramide crystal product can be prepared by conducting simple treatment on the obtained isobutyramide water solution; and the product, which is higher than 99.95% in purity and is free from such harmful ingredients as an organic solvent and the like, is especially applicable to medical field. The method is mild in reaction conditions and simple to operate, simple in preparation process and easy for industrialization, and the yield of the product reaches 99% or above.

Description

technical field [0001] The invention relates to the field of chemical industry, in particular, the invention relates to a preparation method of isobutyramide. Background technique [0002] Isobutyramide can selectively induce human g-globin gene transcription, coupled with the non-toxicity of isobutyramide and the longer half-life in plasma, it makes isobutyramide ideal in the treatment of b-thalassemia and sickle cell anemia Effect. Isobutyramide is also an important intermediate in the synthesis of ritonavir, a drug for the treatment of AIDS. Isobutyramide is widely used in the field of medicine, and the research on various intermediates used in its preparation process and isobutyramide is becoming a hot spot in this field. [0003] There have been some reports on the production and preparation methods of isobutyramide, mainly based on the method of reacting isobutyryl chloride and ammonia. The representative method is the preparation method of isobutyramide proposed by ...

AI Technical Summary

Problems solved by technology

Although the product purity of the isobutyramide obtained by this method for preparing isobutyramide has reached 99.87%, this method has the following disadvantages: the first is because the isobutyryl chloride used is very easy to react with water, in order to avoid Isobutyryl chloride decomposes in contact with water and other substances, and the solvent and other raw materials need to be strictly dewatered, and the reaction equipment needs to be strictly sealed. The reaction process of isobutyryl chloride and ammonia is extremely violent, so the control of the reaction conditions is also very demanding. Strict, these increase the difficulty of preparing isobutyramide

These result in more treatment of the three wastes, it is difficult to meet the requirements of environmental protection, and the cost of production is increased.

The 3rd is that this method process is complicated, and the yield of product is low, has only about 88%, and has used benzene organic solvent in the preparation process, makes the probability increase that contains harmful substance in the product, is exactly the extremely trace amount of organic solvent in different The presence of butanamide also has a great adverse effect on the application of the product in the medical field

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