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A kind of technology of isobutyramide and derivatives, applied in the field of isobutyramide derivative compounds
Pending Publication Date: 2020-06-26
福建莲珂科技有限公司
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Problems solved by technology
In the current cosmetics, there is a lack of anti-inflammatory soothing products that can effectively protect mast cells and inhibit the release of inflammatory mediators
Method used
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Embodiment 1
[0046] The preparation method of octanoyl isobutylamine
[0047] Dissolve 49.5g of isobutylamine and 93.3g of triethylamine in 250ml of dichloromethane, cool down to -10°C, dissolve 100g of octanoyl chloride in 250ml of dichloromethane, and add them dropwise to the aforementioned mixture. 0°C, after the dropwise addition, warm up to room temperature, react for 1h, add 500ml of water to the reaction solution, separate layers, wash the organic phase twice with 500ml of water, concentrate to remove dichloromethane, and obtain 101g of light yellow liquid product (low temperature solidified at 35°C), the yield was 82.5%.
[0048]
Embodiment 2
[0050] The preparation method of lauroyl isobutylamine
[0051] 36.8g of isobutylamine and 69.4g of triethylamine were dissolved in 250ml of dichloromethane, cooled to -10°C, 100g of lauroyl chloride was dissolved in 250ml of dichloromethane, and added dropwise to the aforementioned mixture. 0°C, after the dropwise addition, warm up to room temperature, react for 1h, add 500ml of water to the reaction solution, separate layers, wash the organic phase twice with 500ml of water, concentrate to remove dichloromethane, and obtain 100g of white solid product, yield 86 %.
[0052]
[0053] The octanoyl isobutylamine NMR data that embodiment 1 makes is as follows:
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Abstract
The present invention relates to the technical field of cosmetics, and particularly relates to an isobutyramide derivative compound and an application thereof. The obtained compound can be used for preparing a cosmetic reagent or a pharmaceutical reagent by preparing the series compound which has antihistamine and inhibits skin erythema, pruritus and hyaluronidase. The cosmetic reagent and the pharmaceutical reagent are not specifically limited. For example, the reagents can be washing cosmetics such as skin softening lotion, nutritional lotion, massage cream, body lotion, gel, nutritional cream, facial masks and hair gel or bath cream shampoo, and also can be drug preparation products such as similar cream, ointment, cream, plaster or spray; and when the compound is used for the sensitiveskin, infant and child cosmetics can be also added with the compound to reduce irritation.
Description
technical field [0001] The invention relates to the technical field of cosmetics, in particular to a class of isobutyramide derivative compounds and uses thereof. Background technique [0002] In recent years, with the improvement of living standards, people pay more and more attention to skin health and care. Due to the deterioration of the environment, the increase of life and work pressure, and the excessive use of cosmetics, more and more people's skin barrier is damaged. Inflammation symptoms such as skin erythema and itching begin to appear. Therefore, there is an urgent need for cosmetics with obvious anti-inflammatory effect, safety, and no adverse reactions to relieve allergic symptoms. [0003] Mast cells are widely distributed around the microvessels under the skin and visceral mucosa, and their cells contain specific cytoplasmic granules, which store inflammatory mediators. Existing studies believe that mast cells drive the immediate allergic reaction and are a...
Claims
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Application Information
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