22 results about "Sensitivity skin" patented technology

The invention provides an external application medicine for incontinent dermatitis and a preparation method thereof. The composition is prepared from active ingredients such as a radix sophorae flavescentis extract, calamine, vitamin E, ceramide, a herba portulacae extract, glycyrrhizic acid, chitosan and colloidal oat powder according to a specific proportion. Moisturizing matrixes such as sodium hyaluronate and glycerol and functional components such as tea tree essential oil are supplemented. And through a preparation process of matching high-speed shearing with ultrasonic dispersion, uniform dispersion and stability of each component are ensured. Experimental results show that the composition shows a remarkable synergistic effect in the aspects of anti-inflammation, antibiosis, skin barrier repair and the like, the comprehensive relieving and repairing effect of the composition is superior to that of a conventional drug control, and all the components and a special preparation process are necessary for achieving the optimal effect. The product has no irritation to human skin, is good in safety, can be prepared into various dosage forms such as cream, hydrogel or spray, and is suitable for nursing and repairing sensitive skin.

The invention belongs to the technical field of skin care products, and particularly relates to a mild anti-aging wrinkle-removing skin care active composition as well as a preparation method and application thereof. According to the skin care active composition provided by the invention, the effects of resisting aging and removing wrinkles are achieved through multiple paths of inhibiting oxidative stress, resisting inflammation and relieving reaction, repairing skin barriers in real time and in a long-acting manner and the like, and the skin care effect is achieved. The skin care active composition comprises the helichrysum extract, the lactobacillus fermentation lysate, the palmitoyl pentapeptide-4 and / or the DNA sodium and other active ingredients; efficient anti-aging and wrinkle-removing nursing on sensitive skin is realized; the anti-aging and wrinkle-removing skin care active composition can effectively repair skin barrier and inhibit oxidative stress for a long time, is suitable for nursing sensitive skin accompanied by chronic inflammation, is a mild anti-aging and wrinkle-removing skin care active composition with excellent performance, and solves the technical problem of low performance of an anti-aging and wrinkle-removing skin care product in the prior art.

The present application relates to the cosmetic technical field, specifically disclose a kind of oil-controlling composition and its preparation method and application.A kind of oil-controlling composition, with the percentage of oil-controlling composition, including 2%~5%Verbena leaf extract, 3%~7%Spiraea prunifolia extract, 1%~3%medicinal poria extract, 0.1%~0.3%adenosine, 0.2%~0.5%preservative, 0.5%~1%moisturizing agent, the rest is solvent.A kind of oil-controlling composition preparation method, in sterilization after solvent, adenosine, preservative, Verbena leaf extract, Spiraea prunifolia extract, medicinal poria extract and moisturizing agent are sequentially added, and the oil-controlling composition is obtained after stirring uniformly.The application of a kind of oil-controlling composition is to add oil-controlling composition in cosmetic.The oil-controlling composition of the present application has the effect of significantly inhibiting skin oiliness, repairing skin barrier, maintaining the water-oil balance state of oily sensitive skin.

The application discloses a composition for lightening dark circles under eyes containing camellia chrysantha extract and a preparation method and application thereof, and relates to the technical field of cosmetics.The composition comprises component A, component B and component C;the component A comprises andrographis paniculata extract and camellia chrysantha extract;the component B comprises ubiquinone and safflower extract;and the component C is menthol lactate.The andrographis paniculata extract, the camellia chrysantha extract, the ubiquinone, the safflower extract and the menthol lactate are combined to have a synergistic effect; the composition formed by the specific combination of the components can promote blood microcirculation, inhibit microvascular generation, increase epidermal thickness, relieve cell hypoxia and eye fatigue, reduce blood vessel type dark circles, relieve redness and strengthen skin, and is mild and non-irritating to skin, and is suitable for people with sensitive skin.

This invention relates to a pufferfish TRPV1 inhibitory peptide, its preparation method, and its application. The amino acid sequence of the peptide is LDIF. The preparation method includes: 1. Enzymatically hydrolyzing pufferfish skin, then inactivating the enzyme, and screening for peptides with a molecular weight not greater than 1 kDa from the hydrolysate, followed by freeze-drying to obtain the pufferfish skin enzymatic hydrolysate peptide; 2. Performing mass spectrometry analysis on the pufferfish skin enzymatic hydrolysate peptide, using mass spectrometry analysis software, and selecting multiple non-repeating peptide sequences based on the criteria of confidence level -10lgP > 20 and amino acid count < 10; 3. Molecularly docking the selected peptide sequences with the TRPV1 receptor using software to select peptide sequences with strong binding affinity to the TRPV1 receptor; 4. Solid-phase synthesis of the selected peptide sequences to obtain the peptide LDIF. This invention uses pufferfish skin as raw material to obtain a peptide with good inhibitory effect on TRPV1, which can be used to prepare skin care products for soothing sensitive skin.

The application belongs to the technical field of biotechnology and cosmetics, and discloses a polypeptide with skin barrier repair activity and application thereof. The polypeptide is an enzymatic fragment derived from Bacillus subtilis neutral metalloproteinase A7UAM1, and the amino acid sequence is shown as SEQ ID NO:1. The mutant is a site-directed mutant of the wild-type A7UAM1, and is preferably a H142A / E143A double mutant. Compared with the wild-type enzyme, the proteolytic activity of the polypeptide and the mutant is reduced by greater than or equal to 90%, but the activity of promoting keratinocytes to express filaggrin (FLG) and loricrin (LOR) is not reduced or is significantly improved, and the application realizes the decoupling of the functions of 'gentle exfoliation' and 'active barrier repair'. The polypeptide or the mutant can be applied to the preparation of cosmetics or drugs with the effects of skin barrier repair, anti-sensitivity and anti-photoaging, and is especially suitable for sensitive skin and post-medical aesthetic repair.

The application discloses a composition for relieving itching of sensitive skin and improving barrier and application, and relates to the technical field of cosmetics.The composition comprises component A and component B;the component A comprises flaxseed extract and roselle fruit extract; and the component B comprises annona glabra extract and burscckia yunnanensis extract.The flaxseed extract, the roselle fruit extract, the annona glabra extract and the burscckia yunnanensis extract are combined to find that the flaxseed extract, the roselle fruit extract, the annona glabra extract and the burscckia yunnanensis extract have a synergistic effect, and the composition formed by the specific combination has the effects of relieving facial itching of sensitive skin, reducing excessive activation of neurons and inhibiting inflammation, and repairing an objective barrier and moisturizing.

The invention discloses a construction method of a sensitive skin animal model, and belongs to the technical field of animal model construction. According to the method disclosed by the invention, the sensitive skin animal model is constructed by smearing the lauryl sodium sulfate on the back skin of the mouse after hair removal in combination with veratrine or capsaicin, so that physiological indexes of human sensitive skin can be simulated; key pathological processes of human sensitive skin can be simulated by detecting key pathological indexes such as skin barrier damage, nerve and blood vessel high reactivity, immune inflammation and the like, natural pathophysiological processes of human sensitive skin can be simulated, and pathogenesis of sensitive skin is basically covered; barrier destruction of mouse skin, high reactivity of nerve and blood vessels and inflammatory response are induced, and clinical practice is met. In addition, the method is good in repeatability, high in safety and easy and convenient to operate, sensitive skin medicine screening and personalized treatment scheme development can be promoted, the research and development period of sensitive skin related treatment schemes is shortened, and the application prospect is good.

The invention discloses a preparation method of a phallus impudicus extract as well as a product and application of the phallus impudicus extract, and belongs to the technical field of biology. The phallus impudicus extract is prepared by taking phallus impudicus buds as a raw material and adopting a water extraction process, and the mass percentage of polysaccharide in the extract is not less than 70%. The obtained extract has the biological activity effects of resisting oxidation, resisting inflammation, resisting saccharification, inhibiting elastinase, relieving repair activity or promoting skin repair, and experiments prove that the extract is free of cytotoxicity, sensitization and phototoxicity. The phallus impudicus extract is very suitable for sensitive skin and used as a daily skin care product. Development of traditional fungus phallus impudicus is led to the field of high-tech cosmetic raw materials, a complete technical scheme and solid data support are provided for high value-added utilization of phallus impudicus, and the phallus impudicus is wide in application prospect.

This application discloses a revitalizing and strengthening composition suitable for sensitive skin, its preparation method, and its application, relating to the field of cosmetic technology. This application provides a revitalizing and strengthening composition comprising the following components in parts by weight: 1-2 parts of mulberry root extract, 0.1-2 parts of ceramide, 0.3-0.8 parts of polyglycerol-6 distearate, 0.3-0.8 parts of sorbitan olive oil ester, and 2.5-4 parts of hydrogenated lecithin; wherein the ceramide is a mixture of ceramide EOP and ceramide NP; the revitalizing and strengthening composition is a nanoemulsion with a layered liquid crystal structure, the nanoemulsion comprising an oil phase and an aqueous phase, the oil phase comprising ceramide, polyglycerol-6 distearate, sorbitan olive oil ester, and hydrogenated lecithin, and the aqueous phase comprising mulberry root extract. This application provides a revitalizing and strengthening composition capable of mimicking beneficial light signals, activating and regulating skin opsin pathways, thereby specifically improving skin problems caused by prolonged exposure to indoor environments.

The invention belongs to the technical field of cosmetics, and particularly discloses a sebum-like film composition and application thereof, and the sebum-like film composition comprises the following components in parts by weight: 25-30 parts of a natural fermented oil composition, 1-2 parts of tocopheryl acetate, 0.05-5 parts of ceramide NP, 5-10 parts of glycerol, 0.5-2 parts of 1, 2-hexanediol, 2.5-3 parts of inulin lauryl carbamate, 0.05-0.5 part of sodium surfactin and the balance of deionized water, totaling 100 parts. The natural fermented oil composition is prepared by fermenting phyllanthus emblica kernel oil, sea buckthorn fruit pulp oil and pongamia pinnata seed oil. The sebum-like film composition disclosed by the invention shows excellent compatibility to dry, oily and sensitive skin, and can be used for rapidly repairing barrier injury and reducing percutaneous moisture loss.

The invention relates to a soothing and repairing complex suitable for sensitive skin and a preparation method and application thereof, and belongs to the technical field of cosmetics. The soothing and repairing complex provided by the invention is prepared by coating the surface of microalgae extracellular vesicles with stachyose, astragalus polysaccharide and galactoglucan, the four raw material components cooperate with one another to play a role, and the soothing and repairing complex has the advantages that the soothing and repairing complex aims at a passive fragile state caused by skin immune system imbalance and low tolerance threshold; the saccharide-extracellular vesicle compound is used for simulating mild regulation on a skin immune system, so that the resistance of skin to external environment pressure is systematically improved on the premise of no stimulation risk, and the transformation from passive damage-repair to active defense-toughness is realized; the problems that sensitive skin is easy to stimulate and repeatedly red, the barrier function is weak and the like are fundamentally improved.

The invention provides a sea cucumber peptide microsphere compound. The sea cucumber peptide microsphere compound is nanoparticles formed by wrapping sea cucumber peptide with chitosan analogues, and the chitosan analogue is any one of chitosan, carboxymethyl chitosan and hydroxypropyl chitosan. The HP-CS-NPS (or HPStide-N) provided by the invention provides an innovative active ingredient solution for developing efficient, stable and multifunctional gynecological nursing, cosmetics and skin care products, and is particularly suitable for nursing and repairing sensitive skin and acne skin.

The present application relates to a kind of oil-sensitivity skin's oil control and moisturizing composition and application, belong to cosmetic technical field.The composition is composed of lactobacillus / fermented product extract of black mustard seed, Norway spruce leaf extract, palm-like kelp extract, flaxseed extract, the reasonable compounding of four ingredients, respectively from microecological regulation, source oil control, deep moisturizing and barrier repair etc.Synergistically play the effect of oil control and moisturizing.

The present application relates to the technical field of skin care products, and particularly relates to a soothing stress composition containing camellia extract and application thereof.The composition comprises the following components: camellia extract, porphyridium extract, pseudoillicium leaf extract and ophiopogon japonicus extract, which synergistically regulate and completely intervene in the neuroinflammatory pathway, block the transmission of nerve stimulation signals, reduce the release of neuropeptides and inflammatory factors, and repair damaged nerve barriers, so as to achieve the effect of comprehensively relieving skin sensitive reactions.The composition not only has faster and more durable effects, but also has good safety and applicability, and is particularly suitable for skin protection and conditioning of high-sensitivity skin and in extreme environments.

The disclosed sensor assembly can be used in a patient monitoring system to monitor one or more physiological parameters of a patient. The sensor assembly can include a substrate and one or more electrodes that can include a lattice structure to limit the contact area between the one or more electrodes and the skin of the patient. The sensor assembly can include a connector or connector assembly that facilitates connection between the one or more electrodes and a data acquisition unit. The sensor assembly can be particularly useful for patients with sensitive skin, such as infants in a neonatal intensive care unit (NICU).

This invention discloses the application of glycyrrhizin in the preparation of cosmetics and its cosmetic compositions, belonging to the field of traditional Chinese medicine research and development. Glycyrrhizin is derived from licorice extract purified from licorice raw materials, with a purity of ≥98%. Based on its antioxidant, anti-inflammatory, anti-glycation, elastase inhibitory, and cell migration and repair promoting functions, glycyrrhizin can be used to prepare anti-aging or soothing repair cosmetics. Furthermore, within its effective concentration range, it exhibits no cytotoxicity, non-sensitization, or phototoxicity, making it suitable for preparing anti-aging or soothing repair cosmetic compositions. This cosmetic composition has been proven to significantly improve skin elasticity, reduce stinging and redness, and possesses anti-aging and skin-soothing repair effects, making it widely applicable for the daily maintenance and stabilization of sensitive skin. This invention fills a gap in the application of glycyrrhizin in the cosmetic field, providing favorable support for the widespread application of licorice in cosmetics.

The invention belongs to the technical field of cosmetics, and discloses a facial anti-aging essence based on a composite plant extract and a preparation method of the facial anti-aging essence. According to the essence, plant extracts of matricaria recutita, glycyrrhiza glabra, centella asiatica, rosemary, scutellaria baicalensis, green tea and polygonum cuspidatum, butyrospermum parkii butter and tocopherol are selected, a synergistic anti-aging system is constructed with an extremely low addition amount, and the comprehensive effects of resisting inflammation and oxidation, promoting collagen generation and inhibiting elastase are achieved through the multi-target effect. Fullerene, hydroxyl pinacolone retinoate and acetyl hexapeptide-8 are further introduced, so that the firming and anti-wrinkle effects are remarkably improved. The essence disclosed by the invention has good tightening and anti-wrinkle performance and sensitive skin applicability, is stable in structure, safe and mild, and is suitable for daily face anti-aging nursing.

The present invention relates to the technical field of ameliorating sensitive skin, and in particular, to use of TPPU in the preparation of a product for ameliorating skin sensitivity, the product, and a method for applying TPPU or the product thereof to ameliorate skin sensitivity. Specifically provided is use of TPPU in the preparation of a product for ameliorating skin sensitivity and / or promoting skin soothing, or a method for applying TPPU to ameliorate skin sensitivity and / or for skin anti-aging. TPPU itself can ameliorate skin sensitivity and / or promote skin soothing and produce a good effect, particularly on skin-sensitive individuals.

The present application relates to the field of cosmetic technology, and particularly relates to application of Chaunliancheng polysaccharide in sensitive skin repair and whitening product. The Chaunliancheng polysaccharide powder with polysaccharide content ≥70% and average molecular weight ≤10000 Da is prepared by crushing, water extraction, alcohol precipitation, DEAE-cellulose chromatography purification, dialysis and freeze-drying. The present application realizes preparation of high-purity and low-molecular-weight Chaunliancheng polysaccharide, and simultaneously has the functions of antioxidation, melanin inhibition, anti-glycation and cell repair promotion on the basis of single component, and has no irritation to sensitive skin, effectively solving the problems of easy irritation of effective components and invalidity of mild components in the current technology. The Chaunliancheng polysaccharide prepared by the present application has high efficiency in whitening, barrier repair, anti-glycation and antioxidation, and high safety, and is suitable for development of sensitive skin repair and whitening product, and has good industrial value.

The invention provides an application of fermented artemisia apiacea oil in relieving sensitive skin and / or resisting aging of sensitive skin, which is characterized in that the content of arteannuic acid in the fermented artemisia apiacea oil is greater than or equal to 0.03 wt%, the acid value of the fermented artemisia apiacea oil is less than or equal to 2.5 mg / g, the peroxide value of the fermented artemisia apiacea oil is less than or equal to 0.650 g / 100g, and the density of the fermented artemisia apiacea oil is 0.9-0.95 g / cm < 3 >. The invention also relates to application of the fermented artemisia apiacea oil in preparation of a skin external preparation with skin soothing and / or skin anti-aging effects.

The invention discloses a composition for sensitive skin care as well as a preparation method and application thereof. The composition is prepared from the following components in percentage by mass: 2.0 to 4.0 percent of erythritol, 0.2 to 0.5 percent of herba centellae extract, 0.05 to 0.2 percent of crocus sativus extract, 0.05 to 0.2 percent of hydrolyzed sodium hyaluronate, 0.1 to 0.3 percent of dipotassium glycyrrhizinate, 1.5 to 3.0 percent of glycerol, 0.3 to 1.0 percent of 1, 2-hexanediol, 0.3 to 0.8 percent of ethylhexylglycerol, 1.0 to 3.0 percent of 1, 3-propylene glycol, 1.0 to 3.0 percent of butanediol, 0.3 to 0.8 percent of p-hydroxyacetophenone and the balance of water. The composition obtained by the invention is a water-based spray, is colorless to faint yellow clear liquid, and is suitable for postoperative skin care, sensitive skin or elderly skin.