13 results about "Sensitivity skin" patented technology

The application discloses a composition for lightening dark circles under eyes containing camellia chrysantha extract and a preparation method and application thereof, and relates to the technical field of cosmetics.The composition comprises component A, component B and component C;the component A comprises andrographis paniculata extract and camellia chrysantha extract;the component B comprises ubiquinone and safflower extract;and the component C is menthol lactate.The andrographis paniculata extract, the camellia chrysantha extract, the ubiquinone, the safflower extract and the menthol lactate are combined to have a synergistic effect; the composition formed by the specific combination of the components can promote blood microcirculation, inhibit microvascular generation, increase epidermal thickness, relieve cell hypoxia and eye fatigue, reduce blood vessel type dark circles, relieve redness and strengthen skin, and is mild and non-irritating to skin, and is suitable for people with sensitive skin.

This invention relates to a pufferfish TRPV1 inhibitory peptide, its preparation method, and its application. The amino acid sequence of the peptide is LDIF. The preparation method includes: 1. Enzymatically hydrolyzing pufferfish skin, then inactivating the enzyme, and screening for peptides with a molecular weight not greater than 1 kDa from the hydrolysate, followed by freeze-drying to obtain the pufferfish skin enzymatic hydrolysate peptide; 2. Performing mass spectrometry analysis on the pufferfish skin enzymatic hydrolysate peptide, using mass spectrometry analysis software, and selecting multiple non-repeating peptide sequences based on the criteria of confidence level -10lgP > 20 and amino acid count < 10; 3. Molecularly docking the selected peptide sequences with the TRPV1 receptor using software to select peptide sequences with strong binding affinity to the TRPV1 receptor; 4. Solid-phase synthesis of the selected peptide sequences to obtain the peptide LDIF. This invention uses pufferfish skin as raw material to obtain a peptide with good inhibitory effect on TRPV1, which can be used to prepare skin care products for soothing sensitive skin.

The application belongs to the technical field of biotechnology and cosmetics, and discloses a polypeptide with skin barrier repair activity and application thereof. The polypeptide is an enzymatic fragment derived from Bacillus subtilis neutral metalloproteinase A7UAM1, and the amino acid sequence is shown as SEQ ID NO:1. The mutant is a site-directed mutant of the wild-type A7UAM1, and is preferably a H142A / E143A double mutant. Compared with the wild-type enzyme, the proteolytic activity of the polypeptide and the mutant is reduced by greater than or equal to 90%, but the activity of promoting keratinocytes to express filaggrin (FLG) and loricrin (LOR) is not reduced or is significantly improved, and the application realizes the decoupling of the functions of 'gentle exfoliation' and 'active barrier repair'. The polypeptide or the mutant can be applied to the preparation of cosmetics or drugs with the effects of skin barrier repair, anti-sensitivity and anti-photoaging, and is especially suitable for sensitive skin and post-medical aesthetic repair.

The invention discloses a construction method of a sensitive skin animal model, and belongs to the technical field of animal model construction. According to the method disclosed by the invention, the sensitive skin animal model is constructed by smearing the lauryl sodium sulfate on the back skin of the mouse after hair removal in combination with veratrine or capsaicin, so that physiological indexes of human sensitive skin can be simulated; key pathological processes of human sensitive skin can be simulated by detecting key pathological indexes such as skin barrier damage, nerve and blood vessel high reactivity, immune inflammation and the like, natural pathophysiological processes of human sensitive skin can be simulated, and pathogenesis of sensitive skin is basically covered; barrier destruction of mouse skin, high reactivity of nerve and blood vessels and inflammatory response are induced, and clinical practice is met. In addition, the method is good in repeatability, high in safety and easy and convenient to operate, sensitive skin medicine screening and personalized treatment scheme development can be promoted, the research and development period of sensitive skin related treatment schemes is shortened, and the application prospect is good.

The invention discloses a preparation method of a phallus impudicus extract as well as a product and application of the phallus impudicus extract, and belongs to the technical field of biology. The phallus impudicus extract is prepared by taking phallus impudicus buds as a raw material and adopting a water extraction process, and the mass percentage of polysaccharide in the extract is not less than 70%. The obtained extract has the biological activity effects of resisting oxidation, resisting inflammation, resisting saccharification, inhibiting elastinase, relieving repair activity or promoting skin repair, and experiments prove that the extract is free of cytotoxicity, sensitization and phototoxicity. The phallus impudicus extract is very suitable for sensitive skin and used as a daily skin care product. Development of traditional fungus phallus impudicus is led to the field of high-tech cosmetic raw materials, a complete technical scheme and solid data support are provided for high value-added utilization of phallus impudicus, and the phallus impudicus is wide in application prospect.

This application discloses a revitalizing and strengthening composition suitable for sensitive skin, its preparation method, and its application, relating to the field of cosmetic technology. This application provides a revitalizing and strengthening composition comprising the following components in parts by weight: 1-2 parts of mulberry root extract, 0.1-2 parts of ceramide, 0.3-0.8 parts of polyglycerol-6 distearate, 0.3-0.8 parts of sorbitan olive oil ester, and 2.5-4 parts of hydrogenated lecithin; wherein the ceramide is a mixture of ceramide EOP and ceramide NP; the revitalizing and strengthening composition is a nanoemulsion with a layered liquid crystal structure, the nanoemulsion comprising an oil phase and an aqueous phase, the oil phase comprising ceramide, polyglycerol-6 distearate, sorbitan olive oil ester, and hydrogenated lecithin, and the aqueous phase comprising mulberry root extract. This application provides a revitalizing and strengthening composition capable of mimicking beneficial light signals, activating and regulating skin opsin pathways, thereby specifically improving skin problems caused by prolonged exposure to indoor environments.

The invention relates to a soothing and repairing complex suitable for sensitive skin and a preparation method and application thereof, and belongs to the technical field of cosmetics. The soothing and repairing complex provided by the invention is prepared by coating the surface of microalgae extracellular vesicles with stachyose, astragalus polysaccharide and galactoglucan, the four raw material components cooperate with one another to play a role, and the soothing and repairing complex has the advantages that the soothing and repairing complex aims at a passive fragile state caused by skin immune system imbalance and low tolerance threshold; the saccharide-extracellular vesicle compound is used for simulating mild regulation on a skin immune system, so that the resistance of skin to external environment pressure is systematically improved on the premise of no stimulation risk, and the transformation from passive damage-repair to active defense-toughness is realized; the problems that sensitive skin is easy to stimulate and repeatedly red, the barrier function is weak and the like are fundamentally improved.

The invention provides a sea cucumber peptide microsphere compound. The sea cucumber peptide microsphere compound is nanoparticles formed by wrapping sea cucumber peptide with chitosan analogues, and the chitosan analogue is any one of chitosan, carboxymethyl chitosan and hydroxypropyl chitosan. The HP-CS-NPS (or HPStide-N) provided by the invention provides an innovative active ingredient solution for developing efficient, stable and multifunctional gynecological nursing, cosmetics and skin care products, and is particularly suitable for nursing and repairing sensitive skin and acne skin.

The present application relates to the technical field of skin care products, and particularly relates to a soothing stress composition containing camellia extract and application thereof.The composition comprises the following components: camellia extract, porphyridium extract, pseudoillicium leaf extract and ophiopogon japonicus extract, which synergistically regulate and completely intervene in the neuroinflammatory pathway, block the transmission of nerve stimulation signals, reduce the release of neuropeptides and inflammatory factors, and repair damaged nerve barriers, so as to achieve the effect of comprehensively relieving skin sensitive reactions.The composition not only has faster and more durable effects, but also has good safety and applicability, and is particularly suitable for skin protection and conditioning of high-sensitivity skin and in extreme environments.

The disclosed sensor assembly can be used in a patient monitoring system to monitor one or more physiological parameters of a patient. The sensor assembly can include a substrate and one or more electrodes that can include a lattice structure to limit the contact area between the one or more electrodes and the skin of the patient. The sensor assembly can include a connector or connector assembly that facilitates connection between the one or more electrodes and a data acquisition unit. The sensor assembly can be particularly useful for patients with sensitive skin, such as infants in a neonatal intensive care unit (NICU).

This invention discloses the application of glycyrrhizin in the preparation of cosmetics and its cosmetic compositions, belonging to the field of traditional Chinese medicine research and development. Glycyrrhizin is derived from licorice extract purified from licorice raw materials, with a purity of ≥98%. Based on its antioxidant, anti-inflammatory, anti-glycation, elastase inhibitory, and cell migration and repair promoting functions, glycyrrhizin can be used to prepare anti-aging or soothing repair cosmetics. Furthermore, within its effective concentration range, it exhibits no cytotoxicity, non-sensitization, or phototoxicity, making it suitable for preparing anti-aging or soothing repair cosmetic compositions. This cosmetic composition has been proven to significantly improve skin elasticity, reduce stinging and redness, and possesses anti-aging and skin-soothing repair effects, making it widely applicable for the daily maintenance and stabilization of sensitive skin. This invention fills a gap in the application of glycyrrhizin in the cosmetic field, providing favorable support for the widespread application of licorice in cosmetics.

The invention belongs to the technical field of cosmetics, and discloses a facial anti-aging essence based on a composite plant extract and a preparation method of the facial anti-aging essence. According to the essence, plant extracts of matricaria recutita, glycyrrhiza glabra, centella asiatica, rosemary, scutellaria baicalensis, green tea and polygonum cuspidatum, butyrospermum parkii butter and tocopherol are selected, a synergistic anti-aging system is constructed with an extremely low addition amount, and the comprehensive effects of resisting inflammation and oxidation, promoting collagen generation and inhibiting elastase are achieved through the multi-target effect. Fullerene, hydroxyl pinacolone retinoate and acetyl hexapeptide-8 are further introduced, so that the firming and anti-wrinkle effects are remarkably improved. The essence disclosed by the invention has good tightening and anti-wrinkle performance and sensitive skin applicability, is stable in structure, safe and mild, and is suitable for daily face anti-aging nursing.

The present invention relates to the technical field of ameliorating sensitive skin, and in particular, to use of TPPU in the preparation of a product for ameliorating skin sensitivity, the product, and a method for applying TPPU or the product thereof to ameliorate skin sensitivity. Specifically provided is use of TPPU in the preparation of a product for ameliorating skin sensitivity and / or promoting skin soothing, or a method for applying TPPU to ameliorate skin sensitivity and / or for skin anti-aging. TPPU itself can ameliorate skin sensitivity and / or promote skin soothing and produce a good effect, particularly on skin-sensitive individuals.