32 results about "Glucose sensitivity" patented technology

This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates. The diboron compounds are characterized by formula (I), which is: R1-X—R2, and wherein “X” is a mono- to multiatomic linker and where R1 and R2, which may be identical or different, each represents a group of Formula (11a) or (IIb) Also described are diboron conjugates represented by the general Formula (I′), which is: R1′-X′—R2′, in which either the moeities R1′ or R2′ or X′ carry a drug that is covalently attached to the diboron compound.

An object is to provide a composition containing a pancreatic islet, a cell structure containing a pancreatic islet or a pancreatic islet cell, a pancreatic islet transplantation kit, a pancreatic islet transplantation treatment agent, and a hypoglycemic agent which improve at least one of glucose sensitivity or blood sugar level-reducing performance after transplantation, and to provide a composition containing a pancreatic islet, a kit containing a pancreatic islet, a pancreatic islet cell transplantation treatment agent, and a hypoglycemic agent which can improve glucose sensitivity. A composition including (A): a cell structure containing a biocompatible macromolecular block and at least one kind of cell and in which a plurality of the above-described macromolecular blocks are arranged in gaps between a plurality of the above-described cells; and (B): a pancreatic islet, and a composition containing a pancreatic islet; and a spheroid formed of at least one type of stem cell are provided.

The invention discloses a new method for preparing an intelligent glucose-sensitive insulin controlled-release biological material. The method comprises the following steps of: firstly, dissolving glucose derivative monomers with C=C derivatives and concanavalin A derivative monomers with C=C double bonds in buffer solution to produce monomer solution; secondly, adding a catalyst in the monomer solution to perform free radical polymerization at a certain temperature; and finally, removing unreacted reactant through dialysis to obtain the glucose-sensitive insulin controlled-release biologicalmaterial. The preparation method has the advantages of convenient implementation, fast reaction process, mild reaction condition and easy production preparation on a large scale. The obtained glucan-concanavalin A insulin controlled-release biological carrier material has the advantages of good glucose-sensitive property and excellent insulin controlled-release performance.

The invention provides a polymer shown in the formula (I). The invention also provides glucose-sensitive nanogel. The glucose-sensitive nanogel comprises polymer nanogel and glucose oxidase electrostatically compounded with the polymer nanogel. The polymer nanogel is obtained by crosslinking of the polymer shown in the formula (1) and sodium perselenide. The preparation method of the glucose-sensitive nanogel comprises the following steps that the polymer shown in the formula (1) and a sodium perselenide aqueous solution undergo a crosslinking reaction in an organic solvent to produce the polymer nanogel; and the polymer nanogel and glucose oxidase undergo an electrostatic compounding reaction in an aqueous solution to produce the glucose-sensitive nanogel. The glucose-sensitive nanogel has good oxidation sensitivity, biocompatibility and glucose sensitivity, can adjust drug release rate and release behavior by responsing a glucose concentration change when being used as a drug carrier, and can realize fast drug release at a high glucose concentration.

The present invention relates to a conjugate of the formula P-L-I, wherein P is a peptide hormone effecting the metabolism of carbohydrates in vivo, L is a hydrolysable linker molecule consisting of Lp and Li, and I is a molecule capable of inhibiting the effect of the peptide hormone P on the metabolism of carbohydrates in vivo. Under in vivo conditions, the conjugate is the major compound. Whenthe concentration of glucose increases in vivo, the concentration of the peptide hormone effecting the metabolism of carbohydrates in vivo also increases.

The invention discloses a preparation method of quick-response glucose-sensitive hydrogel which is quick in response to glucose stimulation in a physiological environment. The preparation method particularly includes adding acrylamidophenylboronic acid and acrylic acid amino ester, N-alkyl acrylamide and acrylamide or methacrylamide and N,N'-methylenebisacrylamide into an alkaline macromolecule aqueous solution, and stirring to dissolve completely so as to obtain a mixed solution; adding catalytic reaction accelerators tetramethylethylenediamine into the mixed solution with uniformly mixing; adding initiators accounting for 0.03-0.3% of monomer mass, into the obtained solution, and conducting room temperature reaction to obtain the hydrogel containing a macromolecular copolymer shown as structural formula (I). Alkaline macromolecules in the preparation method are a macromolecule component containing amino or partially containing lactam group and can enhance glucose sensitivity and responsiveness of the hydrogel in the physiological environment by being added, so that stability in use of the hydrogel is improved.

The preparation of pH- and glucose-sensitive mesoporous silica@polymer drug carrier belongs to the technical field of nanomaterials. 1) preparing catechol-modified mesoporous silica; 2) preparing a polymer containing phenylboronic acid; 3) dispersing catechol-modified mesoporous silica in methanol to form a third solution, and The polymer containing phenylboronic acid is dissolved in methanol to form a fourth solution, and the fourth solution is added to the third solution to react for 12 to 24 hours. After the reaction, the unreacted polymer is centrifuged to obtain the carrier. The aminated mesoporous silica is modified by 3,4-dihydroxybenzaldehyde, so that the surface of the mesoporous silica has a bishydroxyphenol structure and a pH-sensitive imine bond; The polymer with boronic acid structure can form a boronate bond with glucose sensitivity with the bishydroxyphenol structure on the surface of mesoporous silica, and the polymer is modified with polyethylene glycol, which has good biocompatibility.

The invention provides a copolymer with a structure of a formula (I), a preparation method thereof, glucose sensitive micelle containing the same, glucose sensitive medicine-carrying micelle containing the same and a preparation method of the glucose sensitive medicine-carrying micelle. The copolymer provided by the invention comprises a polyethylene glycol monomethyl ether hydrophilic chain segment and a polyglutamic acid hydrophobic chain segment, wherein the polyglutamic acid hydrophobic chain segment takes polyglutamic acid as a main chain and the branch chain contains phenylboric acid groups. In the copolymer, both polyethylene glycol monomethyl ether and the polyglutamic acid have good biocompatibility, the polyglutamic acid has good biodegradability, the carboxyl group has pH sensitivity, and the phenylboric acid group has glucose sensitivity. The copolymer provided by the invention has good biocompatibility, biodegradability, glucose sensitivity and pH sensitivity.

The invention provides a polymer having a structure shown in formula (I), a glucose nano gel having a structure shown in formula (II), a preparation method of the polymer having the structure shown in the formula (I), a preparation method of the glucose nano gel having the structure shown in the formula (II) and a glucose nano gel composition. The glucose nano gel having the structure shown in the formula (II) is prepared by reacting polymers containing methoxy polyethylene glycol hydrophilic chain segments and polyglutamate hydrophobic chain segments under the action of a boric acid derivative crosslinking agent, wherein both the methoxy polyethylene glycol and the polyglutamate have favorable biocompatibility, and the polyglutamate has favorable biodegradability, thereby ensuring that the glucose nano gel having the structure shown in the formula (II) has favorable biocompatibility and biodegradability; and boric acid groups in the boric acid derivative crosslinking agent are sensitive to glucose and can quickly respond to the concentration change of the glucose, thereby being beneficial to the quick release of medicaments and enhancing the curative effect of the medicaments. The formula (II) is shown in the specification.