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Preparation method of pH and glucose dual-sensitive mesoporous silica@polymer drug carrier

A mesoporous silica, dual-sensitivity technology, applied in the field of nanomaterials, to achieve the effect of good biocompatibility and broad application prospects

Inactive Publication Date: 2015-08-12
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of dual response release methods in mesoporous silica polymer drug carrier systems, especially the controlled release system with both pH and glucose responsive functions, has rarely been reported.

Method used

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  • Preparation method of pH and glucose dual-sensitive mesoporous silica@polymer drug carrier
  • Preparation method of pH and glucose dual-sensitive mesoporous silica@polymer drug carrier
  • Preparation method of pH and glucose dual-sensitive mesoporous silica@polymer drug carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Preparation of catechol-modified mesoporous silica

[0036] a. Dissolve 0.3g CTAB, 0.3mL ammonia water and 0.2mLTEOS in 50mL distilled water, place in a 100mL single-necked round bottom flask, and stir in an oil bath at 50°C for 2h. At the end of the reaction, the white precipitate was collected by centrifugation, washed with distilled water and ethanol for 3 to 5 times, and dried to obtain a white powder.

[0037] b. Disperse the white powder obtained in step a in 0.6 g / mL ammonium nitrate ethanol solution, heat to reflux for 12 hours, centrifuge to collect the white precipitate after the reaction, wash with ethanol for 3 to 5 times, and dry to obtain a white powder.

[0038] c. Disperse the white powder obtained in step b in ethanol, add 0.2mL 3-aminopropyltriethoxysilane, heat and reflux at 80°C for 24h, centrifuge to collect the white precipitate after the reaction, wash with ethanol for 3 to 5 times , dried to obtain a white powder.

[0039] d. Disperse the w...

Embodiment 2

[0049] (1) Preparation of catechol-modified mesoporous silica

[0050] a. Dissolve 0.5g CTAB, 0.5mL ammonia water and 0.2mLTEOS in 50mL distilled water, place in a 100mL single-necked round bottom flask, and stir in an oil bath at 50°C for 4h. At the end of the reaction, the white precipitate was collected by centrifugation, washed with distilled water and ethanol for 3 to 5 times, and dried to obtain a white powder.

[0051] b. Disperse the white powder obtained in step a in 0.6 g / mL ammonium nitrate ethanol solution, heat to reflux for 12 hours, centrifuge to collect the white precipitate after the reaction, wash with ethanol for 3 to 5 times, and dry to obtain a white powder.

[0052] c. Disperse the white powder prepared in step b in ethanol, add 0.5mL 3-aminopropyltriethoxysilane, heat and reflux at 80°C for 24h, centrifuge to collect the white precipitate after the reaction, wash with ethanol for 3 to 5 times , dried to obtain a white powder.

[0053] d. Disperse the w...

Embodiment 3

[0062] (1) Preparation of catechol-modified mesoporous silica

[0063] a. Dissolve 0.8g CTAB, 0.8mL ammonia water and 0.4mLTEOS in 60mL distilled water, place in a 100mL single-necked round bottom flask, and stir in an oil bath at 50°C for 4h. At the end of the reaction, the white precipitate was collected by centrifugation, washed with distilled water and ethanol for 3 to 5 times, and dried to obtain a white powder.

[0064] b. Disperse the white powder obtained in step a in 0.6 g / mL ammonium nitrate ethanol solution, heat to reflux for 12 hours, centrifuge to collect the white precipitate after the reaction, wash with ethanol for 3 to 5 times, and dry to obtain a white powder.

[0065] c. Disperse the white powder prepared in step b in ethanol, add 1mL of 3-aminopropyltriethoxysilane, heat and reflux at 80°C for 24h, centrifuge to collect the white precipitate after the reaction, wash with ethanol for 3 to 5 times, Drying gave a white powder.

[0066] d. Disperse the white...

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Abstract

The invention relates to a preparation method of a pH and glucose dual-sensitive mesoporous silica@polymer drug carrier, and belongs to the technical field of nanomaterials. The preparation method comprises the following steps: 1, preparing catechol modified mesoporous silica; 2, preparing a phenylboric acid-containing polymer; and 3, dispersing catechol modified mesoporous silica in methanol to prepare a third solution, dissolving the phenylboric acid-containing polymer in methanol to prepare a fourth solution, adding the fourth solution to the third solution, reacting for 12-24h, and centrifuging after the reaction to remove unreacted polymer in order to obtain the carrier. Aminated mesoporous silica is modified with 3,4-dihydroxy benzaldehyde to make the surface of the mesoporous silica have a dihydroxy phenol structure and connected with a pH-sensitive imine bond; and the synthesized phenylboric acid-containing polymer and the dihydroxy phenol structure on the surface of the mesoporous silica form a glucose-sensitive borate ester bond, and the polymer is modified with polyethylene glycol, so the biocompatibility is good.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and in particular relates to a method for preparing a mesoporous silicon dioxide polymer drug carrier with dual sensitivity to pH and glucose. Background technique [0002] In recent years, mesoporous materials have become a research and development hotspot due to their unique and excellent properties, and their application prospects in catalysis, adsorption separation, drug release and other fields have attracted more attention. Since Kresge et al first reported an ordered mesoporous silica material named MCM-41 in Nature in 1992, the research on mesoporous silica has rapidly become an international hotspot. The emergence of ordered mesoporous silica is a leap in the history of molecular sieves and porous materials. [0003] Mesoporous silica nanoparticles (MSN) have the characteristics of continuously adjustable uniform mesoporous pore size in the range of 2-50nm, regular channels,...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K47/04C08F283/06C08F8/42
Inventor 戴李宗毛杰袁丛辉邵志恒刘诚陈婷许一婷罗伟昂
Owner XIAMEN UNIV
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