Glucose-sensitive peptide hormones
A technology for glucose and peptide hormones, applied in the field of pharmaceutical or veterinary compositions, drugs for treating diabetes, and reagents for inactivating or inhibiting the activity of peptide hormones, and can solve problems such as changing the activity of peptide hormones
Inactive Publication Date: 2019-08-02
GUBRA APS
View PDF2 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0036] The peptide conjugates according to the present invention address and solve the problem of altering the hormonal activity of peptide hormones in response to fluctuating carbohydrate concentrations in the body by establishing homeostasis to release active peptide hormones in response to elevated glucose concentrations in vivo
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0166] Example 1 illustrates the synthesis of exemplary hydrolyzable linker (L) molecules.
Embodiment 2
[0167] Example 2 illustrates a method for forming a linker (L) with a handle ready for grafting peptide (P) and inhibitor (I).
Embodiment 3
[0168] Example 3 illustrates the synthesis of a linker attached to an inhibitor (I). In this example, the inhibitor or inactivator complex (I) is a C18 fatty acid, which does not itself inhibit the activity of the peptide (see Example 4), but which is known to bind albumin in vivo. Thus, inactivation in vivo is ultimately achieved by inhibitor binding and aggregation of the conjugate to albumin.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
| Property | Measurement | Unit |
|---|---|---|
| diameter | aaaaa | aaaaa |
Login to View More
Abstract
The present invention relates to a conjugate of the formula P-L-I, wherein P is a peptide hormone effecting the metabolism of carbohydrates in vivo, L is a hydrolysable linker molecule consisting of Lp and Li, and I is a molecule capable of inhibiting the effect of the peptide hormone P on the metabolism of carbohydrates in vivo. Under in vivo conditions, the conjugate is the major compound. Whenthe concentration of glucose increases in vivo, the concentration of the peptide hormone effecting the metabolism of carbohydrates in vivo also increases.
Description
technical field [0001] The present invention relates to glucose-responsive peptide conjugates comprising a peptide hormone that affects carbohydrate metabolism in vivo, and an agent that inactivates or inhibits the activity of the peptide hormone (or an agent that promotes the activity of the peptide hormone) conjugated via a hydrolyzable linker molecule. inactivating or inhibiting reagents). [0002] Furthermore, the present invention relates to the use of the glucose-responsive peptide conjugate as a medicament, in particular as a medicament for the treatment of diabetes. [0003] The peptide hormone part of the conjugate according to the invention is inactive in the conjugate due to the presence of an inhibitor which inactivates or inhibits the activity of the peptide hormone. [0004] The hydrolyzable linker of the conjugate promotes the homeostasis of the peptide hormone, inhibitor and conjugate in vivo. [0005] The invention also relates to a pharmaceutical or veterin...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/54A61P3/10
CPCA61K47/542A61P3/10A61K38/28A61K47/54A61K47/545C07K14/62C07K19/00A61K47/64
Inventor K·J·延森C·S·马德森K·M·S·曼纳斯泰特E·M·贝克S·L·佩德森J·杰尔辛N·弗朗
Owner GUBRA APS
Features
- R&D
- Intellectual Property
- Life Sciences
- Materials
- Tech Scout
Why Patsnap Eureka
- Unparalleled Data Quality
- Higher Quality Content
- 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com