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Polymer, glucose-sensitive nanogel, glucose-sensitive drug-loading nanogel and their preparation methods

A glucose-sensitive, nano-gel technology, applied in the field of polymers, can solve the problem of increasing the biological toxicity of carrier materials, and achieve good glucose-sensitive performance and good stability

Active Publication Date: 2014-04-02
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In order to make the reaction proceed in the positive direction to produce more gluconic acid, catalase is usually loaded in the system to decompose hydrogen peroxide, which also increases the biological toxicity of the carrier material

Method used

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  • Polymer, glucose-sensitive nanogel, glucose-sensitive drug-loading nanogel and their preparation methods
  • Polymer, glucose-sensitive nanogel, glucose-sensitive drug-loading nanogel and their preparation methods
  • Polymer, glucose-sensitive nanogel, glucose-sensitive drug-loading nanogel and their preparation methods

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preparation example Construction

[0050] The invention discloses a preparation method of glucose-sensitive nanogel, comprising the following steps:

[0051] Crosslinking the polymer represented by formula (I) in the above technical solution with an aqueous solution of sodium perselenide in an organic solvent to obtain a polymer nanogel;

[0052] The polymer nanogel and the glucose oxidase are electrostatically compounded in an aqueous solution to obtain the glucose sensitive nanogel.

[0053] In the present invention, first, the polymer represented by the formula (I) described in the above technical solution is cross-linked with an aqueous solution of sodium perselenide in an organic solvent to prepare a polymer nanogel. The organic solvent is preferably dimethyl sulfoxide or N,N-dimethylformamide. The polymer represented by the formula (I) is preferably prepared according to the above technical scheme, and will not be repeated here. The concentration of the aqueous solution of sodium perselenide is 0.1-1 mo...

Embodiment 1

[0061] The preparation of embodiment 1 terminal carboxylated polyethylene glycol monomethyl ether

[0062] Dissolve 10g of polyethylene glycol monomethyl ether (2mmol) and 4g of succinic anhydride (40mmol) in 100mL of pyridine / dichloromethane mixed solvent (v:v=1:9), stir and react at 25°C for 48h, and the reaction ends After adding saturated NaHCO 3 The aqueous solution was neutralized and washed three times with ethyl acetate to remove unreacted pyridine. Add HCl to adjust the pH of the solution to acidity, and add NaCl to saturation, extract with chloroform, and dry with anhydrous magnesium sulfate, filter, settle and dry to constant weight to obtain carboxylated polyethylene glycol monomethyl ether. The yield is 80%.

Embodiment 2

[0063] The purification of embodiment 2 chitosan

[0064] Dissolve 5g of chitosan with 1% (v:v) acetic acid solution at 25°C, and filter to remove insoluble matter, settle with acetone, centrifuge and wash with deionized water, and filter through a G3 funnel. The acetic acid dissolution was repeated twice, washed with water and drained for later use. The yield was 69%.

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Abstract

The invention provides a polymer shown in the formula (I). The invention also provides glucose-sensitive nanogel. The glucose-sensitive nanogel comprises polymer nanogel and glucose oxidase electrostatically compounded with the polymer nanogel. The polymer nanogel is obtained by crosslinking of the polymer shown in the formula (1) and sodium perselenide. The preparation method of the glucose-sensitive nanogel comprises the following steps that the polymer shown in the formula (1) and a sodium perselenide aqueous solution undergo a crosslinking reaction in an organic solvent to produce the polymer nanogel; and the polymer nanogel and glucose oxidase undergo an electrostatic compounding reaction in an aqueous solution to produce the glucose-sensitive nanogel. The glucose-sensitive nanogel has good oxidation sensitivity, biocompatibility and glucose sensitivity, can adjust drug release rate and release behavior by responsing a glucose concentration change when being used as a drug carrier, and can realize fast drug release at a high glucose concentration.

Description

technical field [0001] The invention relates to the field of macromolecules, in particular to a polymer, a glucose-sensitive nanogel, a glucose-sensitive drug-loaded nanogel and a preparation method thereof. Background technique [0002] Diabetes refers to a systemic metabolic disorder caused by elevated blood sugar and sugar in the urine due to insufficient insulin secretion in the body. It has become the third serious chronic non-communicable disease after tumors and cardiovascular and cerebrovascular diseases. Diabetes can be divided into two types according to pathological characteristics: insulin-dependent diabetes mellitus (type 1) and non-insulin-dependent diabetes mellitus (type 2). The treatment of type 1 diabetes mainly relies on insulin injection, and insulin is also suitable for the adjuvant treatment of type 2 diabetes and diabetes with complications that cannot be controlled by diet and oral hypoglycemic drugs. Insulin is the main hormone for maintaining blood...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00C08B37/08C08G65/48C08J3/075C08J3/24C08K3/30A61K47/34A61K9/06A61K47/42B82Y5/00B82Y40/00
Inventor 陈学思赵丽丁建勋肖春生庄秀丽
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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