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Preparation of pH- and glucose-sensitive mesoporous silica@polymer drug carrier

A mesoporous silica and dual-sensitivity technology, applied in the field of nanomaterials, achieves good biocompatibility and broad application prospects

Inactive Publication Date: 2018-04-24
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of dual responsive release methods in the mesoporous silica@polymer drug carrier system, especially the controlled release system with both pH and glucose responsive functions, has rarely been reported.

Method used

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  • Preparation of pH- and glucose-sensitive mesoporous silica@polymer drug carrier
  • Preparation of pH- and glucose-sensitive mesoporous silica@polymer drug carrier
  • Preparation of pH- and glucose-sensitive mesoporous silica@polymer drug carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Preparation of catechol-modified mesoporous silica

[0036] a. Dissolve 0.3g CTAB, 0.3mL ammonia water and 0.2mLTEOS in 50mL distilled water, place in a 100mL single-necked round bottom flask, and stir in an oil bath at 50°C for 2h. At the end of the reaction, the white precipitate was collected by centrifugation, washed with distilled water and ethanol for 3 to 5 times, and dried to obtain a white powder.

[0037] b. Disperse the white powder obtained in step a in 0.6 g / mL ammonium nitrate ethanol solution, heat to reflux for 12 hours, centrifuge to collect the white precipitate after the reaction, wash with ethanol for 3 to 5 times, and dry to obtain a white powder.

[0038] c. Disperse the white powder obtained in step b in ethanol, add 0.2mL 3-aminopropyltriethoxysilane, heat and reflux at 80°C for 24h, centrifuge to collect the white precipitate after the reaction, wash with ethanol for 3 to 5 times , dried to obtain a white powder.

[0039] d. Disperse the w...

Embodiment 2

[0049] (1) Preparation of catechol-modified mesoporous silica

[0050] a. Dissolve 0.5g CTAB, 0.5mL ammonia water and 0.2mLTEOS in 50mL distilled water, place in a 100mL single-necked round bottom flask, and stir in an oil bath at 50°C for 4h. At the end of the reaction, the white precipitate was collected by centrifugation, washed with distilled water and ethanol for 3 to 5 times, and dried to obtain a white powder.

[0051] b. Disperse the white powder obtained in step a in 0.6 g / mL ammonium nitrate ethanol solution, heat to reflux for 12 hours, centrifuge to collect the white precipitate after the reaction, wash with ethanol for 3 to 5 times, and dry to obtain a white powder.

[0052] c. Disperse the white powder prepared in step b in ethanol, add 0.5mL 3-aminopropyltriethoxysilane, heat and reflux at 80°C for 24h, centrifuge to collect the white precipitate after the reaction, wash with ethanol for 3 to 5 times , dried to obtain a white powder.

[0053] d. Disperse the w...

Embodiment 3

[0062] (1) Preparation of catechol-modified mesoporous silica

[0063] a. Dissolve 0.8g CTAB, 0.8mL ammonia water and 0.4mLTEOS in 60mL distilled water, place in a 100mL single-necked round bottom flask, and stir in an oil bath at 50°C for 4h. At the end of the reaction, the white precipitate was collected by centrifugation, washed with distilled water and ethanol for 3 to 5 times, and dried to obtain a white powder.

[0064] b. Disperse the white powder obtained in step a in 0.6 g / mL ammonium nitrate ethanol solution, heat to reflux for 12 hours, centrifuge to collect the white precipitate after the reaction, wash with ethanol for 3 to 5 times, and dry to obtain a white powder.

[0065] c. Disperse the white powder prepared in step b in ethanol, add 1mL of 3-aminopropyltriethoxysilane, heat and reflux at 80°C for 24h, centrifuge to collect the white precipitate after the reaction, wash with ethanol for 3 to 5 times, Drying gave a white powder.

[0066] d. Disperse the white...

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Abstract

The preparation of pH- and glucose-sensitive mesoporous silica@polymer drug carrier belongs to the technical field of nanomaterials. 1) preparing catechol-modified mesoporous silica; 2) preparing a polymer containing phenylboronic acid; 3) dispersing catechol-modified mesoporous silica in methanol to form a third solution, and The polymer containing phenylboronic acid is dissolved in methanol to form a fourth solution, and the fourth solution is added to the third solution to react for 12 to 24 hours. After the reaction, the unreacted polymer is centrifuged to obtain the carrier. The aminated mesoporous silica is modified by 3,4-dihydroxybenzaldehyde, so that the surface of the mesoporous silica has a bishydroxyphenol structure and a pH-sensitive imine bond; The polymer with boronic acid structure can form a boronate bond with glucose sensitivity with the bishydroxyphenol structure on the surface of mesoporous silica, and the polymer is modified with polyethylene glycol, which has good biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to a method for preparing a mesoporous silica@polymer drug carrier with dual sensitivity to pH and glucose. Background technique [0002] In recent years, mesoporous materials have become a research and development hotspot due to their unique and excellent properties, and their application prospects in catalysis, adsorption separation, drug release and other fields have attracted more attention. Since Kresge et al first reported an ordered mesoporous silica material named MCM-41 in Nature in 1992, the research on mesoporous silica has rapidly become an international hotspot. The emergence of ordered mesoporous silica is a leap in the history of molecular sieves and porous materials. [0003] Mesoporous silica nanoparticles (MSN) have the characteristics of continuously adjustable uniform mesoporous pore size in the range of 2-50nm, regular channels, stable skeleto...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/32A61K47/04C08F283/06C08F8/42
Inventor 戴李宗毛杰袁丛辉邵志恒刘诚陈婷许一婷罗伟昂
Owner XIAMEN UNIV
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