Copolymer, glucose sensitive micelle, glucose sensitive medicine-carrying micelle and preparation method thereof

A technology of glucose-sensitive and drug-loaded micelles, which is applied in the field of glucose-sensitive materials, can solve problems such as limitations in the field of bioavailability of glucose-sensitive materials, and achieve good biodegradability and good biocompatibility
CN102391504AActive Publication Date: 2012-03-28CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
Publication Date
2012-03-28

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Abstract

The invention provides a copolymer with a structure of a formula (I), a preparation method thereof, glucose sensitive micelle containing the same, glucose sensitive medicine-carrying micelle containing the same and a preparation method of the glucose sensitive medicine-carrying micelle. The copolymer provided by the invention comprises a polyethylene glycol monomethyl ether hydrophilic chain segment and a polyglutamic acid hydrophobic chain segment, wherein the polyglutamic acid hydrophobic chain segment takes polyglutamic acid as a main chain and the branch chain contains phenylboric acid groups. In the copolymer, both polyethylene glycol monomethyl ether and the polyglutamic acid have good biocompatibility, the polyglutamic acid has good biodegradability, the carboxyl group has pH sensitivity, and the phenylboric acid group has glucose sensitivity. The copolymer provided by the invention has good biocompatibility, biodegradability, glucose sensitivity and pH sensitivity.
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Description

technical field

[0001] The invention belongs to the technical field of glucose-sensitive materials, and in particular relates to a copolymer, glucose-sensitive micelles, glucose-sensitive drug-loaded micelles and a preparation method thereof. Background technique

[0002] Diabetes is currently one of the three major diseases that endanger human health. Clinically, insulin injections are generally used for drug administration. However, for diabetic patients, injecting insulin several times a day is not only troublesome, but also causes skin redness, swelling, itching, induration, infection, etc., and even serious side effects such as subcutaneous fat atrophy or fibrosis hyperplasia. Smart materials are a class of polymer materials that can respond to external environmental stimuli, such as temperature, pH, ion concentration, glucose, etc. The self-regulating drug delivery system combined with glucose-sensitive materials can reduce the side effects of frequent insulin injecti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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