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Polymer, glucose nano gel, glucose nano gel composition and preparation method thereof

A nanogel and polymer technology, applied in the field of glucose nanogel, glucose nanogel composition and its preparation, and polymer, can solve the limitations of application fields, poor biocompatibility, and poor biodegradability of glucose nanogel and other issues, to achieve good biocompatibility, improve curative effect, and good biodegradability

Active Publication Date: 2013-02-27
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned glucose nanogels are relatively sensitive to glucose concentration, but they are all prepared by non-biodegradable materials and chemical cross-linking methods. Therefore, the obtained glucose nanogels have poor biodegradability and poor biocompatibility, so their application fields are extremely popular. big limit

Method used

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  • Polymer, glucose nano gel, glucose nano gel composition and preparation method thereof
  • Polymer, glucose nano gel, glucose nano gel composition and preparation method thereof
  • Polymer, glucose nano gel, glucose nano gel composition and preparation method thereof

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preparation example Construction

[0058] The present invention also provides a method for preparing a polymer having a structure of formula (I), comprising the following steps:

[0059]reacting the polymer with the structure of formula (III) and 2-azidoethyl-D-(+)-glucopyranoside under the action of a catalyst to obtain the polymer with the structure of formula (I);

[0060]

[0061] Formula (III);

[0062]

[0063] Formula (I);

[0064] Wherein, m is the degree of polymerization, 55≤m≤250, preferably 100≤m≤200, more preferably 110≤m≤150; n is the degree of polymerization, 20≤n≤150, preferably 30≤n≤120, more preferably Preferably 40≤n≤100;

[0065] 0.1≤i / (i+j)≤1, preferably 0.1≤i / (i+j)<1, more preferably 0.3≤i / (i+j)≤0.7, most preferably 0.4≤i / (i +j) ≤ 0.7.

[0066] In the present invention, the polymer having the structure of formula (III) is reacted with 2-azidoethyl-D-(+)-glucopyranoside under the action of a catalyst to obtain the polymer having the structure of formula (I) . The catalyst is pre...

Embodiment 1

[0129] After azeotroping 25g of polyethylene glycol monomethyl ether (molecular weight: 5000) with toluene to remove water, dissolve it in 150mL of anhydrous dichloromethane, add 3.5mL of triethylamine at 0°C and anhydrous conditions, and drop 8mL Methanesulfonyl chloride was reacted at 0°C for 2h, returned to 25°C, and continued to react for 48h under stirring with a stirrer. After the reaction was completed, the resulting precipitate was filtered off, and the filtrate was settled with ether, filtered, washed, and vacuumed at 25°C. After drying for 24 hours, polyethylene glycol monomethyl ether methanesulfonate was obtained.

[0130] Dissolve 3 g of the above-prepared polyethylene glycol monomethyl ether methanesulfonate and 1 g of ammonium chloride in 80 mL of ammonia water with a mass concentration of 25%, react at 25°C for 72 hours, and obtain amino-terminated polyethylene glycol after the reaction Monomethyl ether, the aminated polyethylene glycol monomethyl ether was ext...

Embodiment 2

[0132] Add 1.041 g (0.208 mmol) of amino-terminated polyethylene glycol monomethyl ether hydrochloride (mPEG-NH 2 HCl), using toluene to azeotropically remove water and then dissolving with anhydrous N,N-dimethylformamide to obtain amino-terminated polyethylene glycol monomethyl ether hydrochloride solution.

[0133]3.2875g (12.49mmol) of the compound (BLG-NCA) with the formula (IV) and 2.635g (12.49mmol) of the compound (PLG-NCA) with the formula (V) were treated with anhydrous N,N-dimethyl Formamide was dissolved and added to the amino-terminated polyethylene glycol monomethyl ether hydrochloride solution, and the reaction was carried out at 25°C under stirring with a stirrer. The reaction time was 72 hours. After the reaction was completed, the solution was poured into the volume Settled in diethyl ether 10 times the amount of the solvent, filtered, washed, and dried in vacuum at 25°C for 24 hours to obtain a polymer with the structure of formula (III) (mPEG-b-P(BLG-co-PLG)...

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Abstract

The invention provides a polymer having a structure shown in formula (I), a glucose nano gel having a structure shown in formula (II), a preparation method of the polymer having the structure shown in the formula (I), a preparation method of the glucose nano gel having the structure shown in the formula (II) and a glucose nano gel composition. The glucose nano gel having the structure shown in the formula (II) is prepared by reacting polymers containing methoxy polyethylene glycol hydrophilic chain segments and polyglutamate hydrophobic chain segments under the action of a boric acid derivative crosslinking agent, wherein both the methoxy polyethylene glycol and the polyglutamate have favorable biocompatibility, and the polyglutamate has favorable biodegradability, thereby ensuring that the glucose nano gel having the structure shown in the formula (II) has favorable biocompatibility and biodegradability; and boric acid groups in the boric acid derivative crosslinking agent are sensitive to glucose and can quickly respond to the concentration change of the glucose, thereby being beneficial to the quick release of medicaments and enhancing the curative effect of the medicaments. The formula (II) is shown in the specification.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a polymer, a glucose nanogel, a glucose nanogel composition and a preparation method thereof. Background technique [0002] At present, the number of diabetic patients is showing a sharp increase. The World Health Organization (WHO) predicts that the number of diabetic patients in the world will increase to 366 million in 2030, including 42 million in China. It can be seen that the treatment of diabetes is imminent. Diabetes is an endogenous disease in which blood sugar rises due to insufficient insulin secretion in the body and contains sugar in the urine. For the treatment of diabetes, insulin injections are generally used clinically. Although injecting insulin can quickly achieve the goal of lowering blood sugar, injecting insulin several times a day is not only troublesome, but also causes serious side effects such as skin redness, itching, induration, and infection...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G69/48C08G69/40C08J3/24C08L77/04A61K47/34
Inventor 陈学思赵丽肖春生丁建勋何盼汤朝晖
Owner CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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