Application of ZNRF3/RNF43 in preparation of medicine for regulating energy metabolism

An energy metabolism and drug technology, applied in metabolic diseases, drug combinations, pharmaceutical formulations, etc., can solve problems such as lack of energy metabolism, and achieve the effects of improving liver insulin resistance, reducing liver lipid deposition, and increasing glucose sensitivity

Active Publication Date: 2020-11-13
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on ZNRF3/RNF43 mainly focuses on tumorigenesis,

Method used

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  • Application of ZNRF3/RNF43 in preparation of medicine for regulating energy metabolism
  • Application of ZNRF3/RNF43 in preparation of medicine for regulating energy metabolism
  • Application of ZNRF3/RNF43 in preparation of medicine for regulating energy metabolism

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Experimental program
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Embodiment 1

[0016] 1. Animal experiments

[0017] ZNRF3&RNF43 liver-specific double knockout male mice (C57BL / 6) were bred at the Animal Breeding Center of Shanghai Jiaotong University and fed at SVF level. Single single cage was raised, and the HFD feed was fed at the age of 8 weeks, and the common diet adopted standard commercial mouse feed (21% protein, 4.5% fat, 4% cellulose, caloric 1.404kcal / g), and the high-fat diet feed was purchased from Research Diets (20% carbohydrates, 20% protein, 60% fat), do not restrict water and food intake. Set the ambient temperature to a constant temperature of 22° C., and a 12-hour photoperiod (6:00-18:00 light, 18:00-6:00 dark). The breeding method is that 8-week-old sexually mature male mice and 8-week-old sexually mature female mice are mated in a cage at a ratio of 1:2-1:3, and the toes of the offspring are cut off about 1 week after birth, the mice are numbered, and genetically For type identification, the pups were separated from their mothers...

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Abstract

The invention relates to application of ZNRF3/RNF43 in preparation of a medicine for regulating energy metabolism. It proves that the ZNRF3/RNF43 double knockout can reduce the blood sugar content andserum insulin level, increase the sensitivity of the body to glucose and down-regulate the expression of glucose allogeneic related genes; meanwhile, liver lipid deposition is reduced, lipid synthesis and expression of inflammation-related genes are reduced, it is shown that the ZNRF3/RNF43 double knockout can improve liver insulin resistance possibly through the ways of influencing glycoxenesis,lipid synthesis and the like, and then a theoretical basis is provided for preparing energy metabolism regulating medicine.

Description

technical field [0001] The invention belongs to the field of drugs for type 2 diabetes, and in particular relates to the application of ZNRF3 / RNF43 in the preparation of drugs for regulating energy metabolism. Background technique [0002] Ring finger proteins ZNRF3 (zinc ring finger protein 3) and RNF43 (ring finger protein 43) are two homologous single-transmembrane E3 ubiquitin ligases, both of which belong to the Goliath protein family and are conserved genes in many organisms , is stably expressed in a variety of vertebrates. ZNRF3 is located on human chromosome 22, and RNF43 is located on chromosome 17. The two structures are similar and have certain homology. They are composed of four parts, signal peptide (signal peptide, SP), extracellular domain (protease -associated domain, PA region), transmembrane domain (transmembrane domain) and intracellular ubiquitination functional domain - ring domain (RING domain), ZNRF3 and RNF43 are functional homologues of each other....

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P3/00A61P3/10A61P3/06
CPCA61K45/00A61P3/00A61P3/10A61P3/06
Inventor 宁光张志国姚霜霜袁依妮香敏琪
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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