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Temperature and pH dual-affected xylan-based hydrogel as well as manufacturing method and application thereof

A double-response, xylan-based technology, applied in the direction of non-active ingredient medical preparations, aerosol delivery, liquid delivery, etc., to achieve the effect of easy operation, environmental friendliness and easy process

Active Publication Date: 2015-01-07
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no reports on temperature and pH sensitive hydrogels prepared from xylan-type hemicelluloses and their application in sustained release of drugs

Method used

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  • Temperature and pH dual-affected xylan-based hydrogel as well as manufacturing method and application thereof
  • Temperature and pH dual-affected xylan-based hydrogel as well as manufacturing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A temperature and pH dual response xylan-based hydrogel, the preparation steps are as follows:

[0041] Weigh 2.5g of xylan (xylan) into a three-necked flask, add 50mL of deionized water, heat at 80°C for 30min and stir to dissolve; cool down to 50°C, then add 0.25g of N-isopropylacrylamide (NIPA), 25g acrylamide (AM) and 0.25g N,N'-methylenebisacrylamide (MBA), bubbled with nitrogen for 15min to remove dissolved oxygen in the solution and air in the bottle; then add photoinitiated benzoin dimethyl ether 0.125g (dissolve benzoin dimethyl ether 0.125g in N-methylpyrrolidone first, the mass concentration is 2.5%); after the mixed solution is uniform, it is cooled to room temperature, poured into a quartz dish and placed in ultraviolet In the reactor, set the irradiation conditions as follows: the wavelength is 365nm, the power is 400W, and the irradiation is at room temperature for 6h; The gel is taken out and washed with excess deionized water to remove residual reactio...

Embodiment 2

[0051] A temperature and pH dual response xylan-based hydrogel, the preparation steps are as follows:

[0052] Weigh 3.0g xylan into a three-necked flask, add 50mL deionized water, heat at 60°C for 40min and stir to dissolve; cool down to 50°C, then add 0.45g of N-isopropylacrylamide (NIPA), 24g of acrylamide (AM) and 0.18g of N,N'-methylenebisacrylamide (MBA), bubbled with nitrogen for 30min to remove dissolved oxygen in the solution and air in the bottle; then add photoinitiated 0.15g of benzoin dimethyl ether (dissolve 0.15g of benzoin dimethyl ether in N-methylpyrrolidone first, and the mass concentration is 2.5%); after the mixed solution is uniform, it is cooled to room temperature, poured into a quartz dish and placed in ultraviolet radiation In the reactor, set the irradiation conditions as follows: the wavelength is 365nm, the power is 400W, and the irradiation is at room temperature for 8h; The gel is taken out and washed with excess deionized water to remove residu...

Embodiment 3

[0057] A temperature and pH dual response xylan-based hydrogel, the preparation steps are as follows:

[0058] Weigh 3.0g of xylan (xylan) into a three-necked flask, add 75mL of deionized water, heat at 70°C for 15min and stir to dissolve; cool down to 50°C, then add 0.24g of N-isopropylacrylamide (NIPA), 45g of acrylamide (AM) and 0.24g of N,N'-methylenebisacrylamide (MBA), bubbled with nitrogen for 10min to remove dissolved oxygen in the solution and air in the bottle; then add photoinitiated 0.15g of benzoin dimethyl ether (dissolve 0.15g of benzoin dimethyl ether in N-methylpyrrolidone first, and the mass concentration is 2.5%); after the mixed solution is uniform, it is cooled to room temperature, poured into a quartz dish and placed in ultraviolet radiation In the reactor, set the irradiation conditions as follows: the wavelength is 365nm, the power is 400W, and it is irradiated at room temperature for 4h; The gel is taken out and washed with excess deionized water to r...

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Abstract

The invention belongs to the technical field of natural polymer functional material preparation, and discloses a temperature and pH dual-affected xylan-based hydrogel as well as a manufacturing method and application thereof. The temperature and pH dual-affected xylan-based hydrogel is prepared through the following steps: dissolving xylan by using hot water, so that a xylan solution is obtained; adding N-isopropylacrylamide and acrylamide into the xylan solution, adding a crosslinking agent, feeding nitrogen for bubbling, adding a photoinitiator, uniformly mixing, cooling the obtained mixture to room temperature, putting the obtained mixture into an ultraviolet radiation reactor, carrying out ultraviolet irradiation at room temperature, carrying out closed placement and reaction at room temperature, and after the reaction is completed, washing the obtained product by using deionized water, so that an obtained solid is the temperature and pH dual-affected xylan-based hydrogel. The preparation process and method of the hydrogel disclosed by the invention are easy to operate, and the hydrogel has environmental friendliness; and the obtained temperature and pH dual-affected xylan-based hydrogel has biocompatibility, and has good sustained-release behavior on medications, and the release of medications in a simulated intestinal physiological fluid is up to 80%.

Description

technical field [0001] The invention belongs to the technical field of preparation of natural polymer functional materials, and in particular relates to a xylan-based hydrogel with dual response to temperature and pH, a preparation method and application thereof. Background technique [0002] Plants around the world produce 3.5×10 hemicellulose per year 10 There are so many t. Hemicellulose is one of the most abundant and cheapest renewable resources on earth, and it is an inexhaustible renewable resource in nature. Hemicellulose is a rational raw material for the preparation of materials due to its wide range of sources, biodegradability, biocompatibility, and special physiological activities. As the main component of hemicellulose, xylan mainly exists in hardwoods and grasses. Xylan itself has special physical and chemical properties that other natural polymers such as cellulose and starch do not have, and has potential application value in the pharmaceutical industry. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F220/56C08F220/54C08F222/38C08J3/075A61K47/36A61K9/06
Inventor 任俊莉高存殿孙润仓孔维庆
Owner SOUTH CHINA UNIV OF TECH
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