42 results about "Arteriosclerosis obliterans" patented technology

A novel polypeptide, and an antibacterial agent, antifungal agent and / or antiseptic containing as an effective ingredient the polypeptide are disclosed. The polypeptide of this invention has an amino acid sequence shown in SEQ ID NOs:1 to 12 and 13 to 31. This antibacterial agent, antifungal agent and / or antiseptic is useful for the prevention, amelioration or treatment of diseases such as burn, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliterans, cellulitis, acute lymphangitis, lymphadenitis, erysipelas, skin abscess, necrotizing subcutaneous infection, staphylococcal scalded skin syndrome (SSSS), folliculitis, facial furuncle, suppurative hidradenitis, carbuncle, infectious paronychia, erythrasma and severe infection (sepsis).

It relates to an endogenous repair factor production accelerator which comprises one or at least two selected from prostaglandin (PG) I2 agonist, EP2 agonist and EP4 agonist. Since prostaglandin (PG) I2 agonist, EP2 agonist or EP4 agonist has various endogenous repair factor production accelerating action, angiogenesis acceleration action and stem cell differentiation induction action, it is useful as preventive and / or therapeutic agents for ischemic organ diseases (e.g., arteriosclerosis obliterans, Buerger disease, Raynaud disease, myocardial infarction, angina pectoris, diabetic neuropathy, spinal canal stenosis, cerebrovascular accidents, cerebral infarction, pulmonary hypertension, bone fracture, Alzheimer disease, etc.) and various cell and organ diseases.

An agent for improving abnormal glucose tolerance or a preventive and / or a remedy for diseases caused by abnormal glucose tolerance containing a chymase inhibitor as the active ingredient. Examples of the diseases caused by abnormal glucose tolerance include diabetes and / or complications of diabetes. Examples of the complications of diabetes include diabetic nephropathy, diabetic retinopathy, diabetic peripheral neuropathy, hyperinsulinemia, insulin resistance syndrome, arteriosclerosis, acute coronary syndrome, arteriosclerosis obliterans, vasculitis, brain infarction, hypertension, renal insufficiency, neuropathy, nephritis, renal aneurysm, renal infarction, obesity and so on.

It relates to an endogenous repair factor production accelerator which comprises one or at least two selected from prostaglandin (PG) 12 agonist, EP2 agonist and EP4 agonist. Since prostaglandin (PG) 12 agonist, EP2 agonist or EP4 agonist has various endogenous repair factor production accelerating action, angiogenesis acceleration action and stem cell differentiation induction action, it is useful as preventive and / or therapeutic agents for ischemic organ diseases (e.g., arteriosclerosis obliterans, Buerger disease, Raynaud disease, myocardial infarction, angina pectoris, diabetic neuropathy, spinal canal stenosis, cerebrovascular accidents, cerebral infarction, pulmonary hypertension, bone fracture, Alzheimer disease, etc.) and various cell and organ diseases.

The present invention provides drugs containing chymase inhibitors as active ingredients for improving glucose intolerance or preventing and / or treating diseases caused by glucose intolerance. The diseases caused by glucose intolerance are diabetes and / or diabetes complications, wherein the diabetes complications include diabetic nephropathy, diabetic retinopathy, diabetic peripheral neuropathy, hyperinsulinism, insulin resistance syndrome, arteriosclerosis, acute coronary syndrome, arteriosclerosis obliterans, angitis, stroke, hypertension, renal insufficiency, nephropathy, nephritis, renal artery aneurysm, renal infarction, obesity and the like.

The invention belongs to the field of tradtional Chinese medicine preparations, and specifically relates to a tradtional Chinese medicine preparation for treating chronic limb arteriosclerosis obliterans and a preparation method thereof. The tradtional Chinese medicine preparation is characterized by being prepared from the following tradtional Chinese medicinal raw materials: 25-35 parts of angelica, 25-35 parts of Szechuan lovage rhizome, 25-35 parts of red peony root, 25-35 parts of folium artemisiae argyi, 25-35 parts of notopterygium root, 25-35 parts of pericarpium zanthoxyli, 25-35 parts of angelica root, 25-35 parts of crude lateral root of aconite, 25-35 parts of crude arisaema heterophyllum blume, 10-20 parts of dried ginger, 10-20 parts of safflower, 10-20 parts of turmeric, 10-15 parts of zedoary and 5-10 parts of acanthopanax root. The tradtional Chinese medicine preparation has the advantages that the adopted tradtional Chinese medicaments meet the specification of pharmacopoeia of the people's republic of China, so the preparation is safe and reliable. The compatible medicaments have the effects of clearing heat and detoxifying, invigorating qi and nourishing yin, promoting blood circulation to remove blood stasis, reinforcing the kidney and quenching thirst and the like, and has the characteristics of exact treatment effect, quick response, high cure rate, no side effect and the like when being used for treating the chronic limb arteriosclerosis obliterans.

The invention relates to the technical field of traditional Chinese medicines, and discloses a Yiwangao ointment and a preparation method thereof. The Yiwangao ointment disclosed by the invention is prepared by decocting radix astragali, Chinese angelica, ground beetle, radix aconiti, radix aconiti kusnezoffii, cochinchina momordica seed, centipede, frankincense, myrrh, dragon's blood, yellow wax, minium and sesame oil. In the invention, multiple pure natural raw materials are selected as the components of the compound traditional Chinese medicine Yiwangao ointment; the Yiwangao ointment is prepared by decocting with a unique process, realizes a remarkably curative effect on curing symptoms such as angiitis, arteriosclerosis obliterans, diabetic foot, deep and shallow venous thrombus, venous ulcer, various bone diseases, lumbar disc herniation, gout, synovitis, stubborn dermatitis, malignant sore, burn, frostbite and the like, and has the advantages of convenience in use, low cost, remarkable curative effect and the like.

The invention discloses traditional Chinese medicine formulas for treating diabetes and a preparation process. The traditional Chinese medicine formulas comprise a formula for common diabetes, a formula for diabetes constipation, a formula for diabetes complicated with urticaria, a formula for diabetes insomnia, a formula for diabetes complicated with erysipelas, a formula for diabetes complicated with postherpetic neuralgia, a formula for diabetes enteropathy, a formula for diabetic atherosclerosis obliterans and a formula for diabetic peripheral neuropathy; multiple diabetes formulas are provided, the medicine is applied according to indications for patients with different diseases detailedly, and side effects of the medicine are prevented from being caused to the patients with different diseases; by means of the preparation process, the property and flavor and effect of the traditional Chinese medicine are kept for the product, the quality is stable and reliable, the traditional Chinese medicine formulas are suitable for needs of dialectical implementation and recipe changes of clinical diagnosis of traditional Chinese medicine, and the traditional Chinese medicine formulas have the advantages that decocting is not needed, the medicine is convenient to take, absorption is rapid and convenient, the dosage is accurate, safety and cleanliness are achieved, and carrying is convenient.

A novel polypeptide, and an antibacterial agent, antifungal agent and / or antiseptic containing as an effective ingredient the polypeptide are disclosed. The polypeptide of this invention has an amino acid sequence shown in SEQ ID NOs:1 to 12 and 13 to 31. This antibacterial agent, antifungal agent and / or antiseptic is useful for the prevention, amelioration or treatment of diseases such as burn, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliterans, cellulitis, acute lymphangitis, lymphadenitis, erysipelas, skin abscess, necrotizing subcutaneous infection, staphylococcal scalded skin syndrome (SSSS), folliculitis, facial furuncle, suppurative hidradenitis, carbuncle, infectious paronychia, erythrasma and severe infection (sepsis).

The invention discloses a traditional Chinese medicine preparation for treating diabetes mellitus arteriosclerosis obliterans. According to the traditional Chinese medicine, main pathogenesis of the disease is blocked qi and blood, vessel insufficiency, meridian fatigue and resistance developed on the basis of pathogenesis of yin and fluid deficiency and dryness-heat excess of diabetes, so as to generate various concurrent symptoms. The internal traditional Chinese medicines such as lousewort root, rust-coloured crotalaria herb with root, fine-stemmed dendrobium, dunn antiotrema root, sago leaf, laxflower pottsia root and rubia yunnanensis are selected to be matched with the traditional Chinese medicines for soaking and washing, such as caesalpinia minax hance, pteracanthus root, luffa root, longcalyx chonemorpha stem, micromeria biflora benth and piper sarmentosum leaf for treatment. According to a clinical experiment, a relatively good curative effect is obtained; and the side effect is small.

The invention discloses a traditional Chinese medicine composition for treating arteriosclerosis obliterans caused by excessive noxious heat. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 15 parts of aristolochia tagala, 30 parts of strobilanthes dyerianus, 15 parts of root of rubus parvifolius, 30 parts of ecdysanthera rosea, 15 parts of herb of whitebracteole bugle, 15 parts of oxyceros sinensis, 15 parts of root of septemlobate kalopanax, 30 parts of mazus stachydifolius, 30 parts of wedelia chinensis, 25 parts of rabdosia lophanthide, 15 parts of miquel maqzus, 25 parts of hedyotis diffusa, 15 parts of pilea melastomoides, 10 parts of dahurian angelica root, 15 parts of leaf of lithocarpus polystachyus, and 8 parts of licorice. The provided traditional Chinese medicine composition can be used to treat arteriosclerosis obliterans caused by excessive noxious heat, and has the advantages of high efficiency, reliable curative effect, and no relapse.

The invention discloses a compound cell preparation, a preparation method and application of the preparation. The preparation comprises autologous platelet rich plasma (PRP), autologous adipose derived stromal cells (ADSCs) and endothelial progenitor cells (EPCs) of ADSC sources. The preparation method comprises the following steps that fat is collected, and adipocyte is separated; the adipocyte is cultured through an ADSC culture medium to obtain P2-generation autologous ADSCs; the P2-generation autologous ADSCs are cultured through an EPC culture medium to obtain EPCs of P0-generation ADSC sources; anticoagulation peripheral blood of a receptor is collected and centrifuged to obtain PRP, and the application of the compound cell preparation in the medicine for treating lower extremity arteriosclerosis obliterans due to diabetes is achieved. The compound cell preparation has the advantages that the EPC culture medium is adopted for inducing the ADSCs to be cultured, the EPCs with the expression percentage of CD133 as 68.72+ / -11.60% and the expression percentage of vWF as 75.91+ / -9.83% are obtained, bone marrow or mobilized peripheral blood does not need to be collected, and after affected parts of patients with lower extremity arteriosclerosis obliterans due to diabetes are injected with the preparation, the limb pain feeling and cold feeling can be lowered, and the new generation rate of collateral vessels is 100%; the total survival rate is 78.12%, the limb salvage survival rate is 68.00%, and the survival life of artificial limbs of the patients can be effectively prolonged.

The present invention provides a ischemia therapeutic agent that contains vascularization induction factor and gelatin hydrogel, and gradually releases vascularization induction factor, which is useful in treating ishchemia accompanying peripheral circulatory disorders etc. encountering as complications of arteriosclerosis obliterans, Buerger's disease, diabetes and collagen disease.

The invention discloses an external Chinese medicinal preparation for treating peripheral vascular diseases. The external Chinese medicinal preparation is prepared from the following bulk pharmaceuticals in parts by weight: 3-10 parts of Chinese atractylodes, 9-15 parts of large-leaved gentian, 3-9 parts of sappan wood, 3-9 parts of cortex periplocae, 3-30 parts of rhubarb, 6-12 parts of Chinese angelica, 3-9 parts of tree peony bark, 3-9 parts of safflower, 3-15 parts of myrrh, 3-9 parts of willowleaf swallowwort rhizome and 3-9 parts of pseudo-ginseng root. As proved by clinical application, the external Chinese medicinal preparation for treating peripheral vascular diseases disclosed by the invention has a wide application range, can be applied to thromboangiitis obliterans, arteriosclerosis obliterans, deep venous thrombosis, superficial thrombophlebitis, Raynaud's gangrene and the like, and has the advantages of quick response, good curative effect, convenience in using, and the like.

The invention describes the use of betaine for treating and preventing arterites. The invention also describes an orally administered composition for treating arterites and, in particular, intermittent claudication, said composition containing, as an active ingredient, an active therapeutic quantity of betaine glycine by single dose. The invention particularly describes a medicament provided for treating a patient suffering from an intermittent claudication caused by peripheral circulatory disorders such as arteriosclerosis obliterans or by thromboangiitis obliterans.

The invention relates to a traditional Chinese medicine prescription for treating arteriosclerosis obliterans and belongs to the technical field of traditional Chinese pharmacology. The traditional Chinese medicine prescription for treating arteriosclerosis obliterans is mainly prepared from the following components in parts by weight: 200 to 400 parts of galium verum, 200 to 400 parts of radix astragali, 100 to 200 parts of earthworm, 100 to 200 parts of radix paeoniae rubra, 100 to 200 parts of rhizoma alismatis, 100 to 200 parts of scorpio, 100 to 200 parts of beautiful sweetgum fruit, 100to 200 parts of corydalis tuber, 100 to 200 parts of prepared liquorice root and 150 to 300 parts of honeysuckle flower. After the traditional Chinese medicine prescription is used by a user, the healing rate of limb pain is 60 percent, the healing rate of limb afraid of cold is 68.7 percent, the healing rate of limb numbness is 70 percent and the healing rate of intermittent claudication is 68.3percent.

The invention is concerned with use of oral inorganic pyrophosphate for preventing and / or reducing tissue calcification, particularly soft tissue calcification, and / or diseases or disorders characterized by low plasma PPi levels, as, e.g., occurs in chronic kidney disease (CKD), end-stage renal disease (ESRD), generalized arterial calcification of infancy (GACI), Pseudoxanthoma elasticum (PXE), Arterial Calcification Due to Deficiency of CD73 (ACDC), Ehlers-Danlos syndrome, arteriosclerosis obliterans, venous calcifications, crystal deposition disorders, calcification resulting from neurological disorders, calcinosis universalis, calcinosis circumscripta, scleroderma, dermatomyositis, systemic lupus erythematosus, hyperparathyroidism, neoplasms, milk-alkali syndrome, hypervitaminosis D, tumoral calcinosis, hypophosphatemic rickets, ossification of the posterior longitudinal ligament of the spine, myocardial ischemia, joint calcification, heterotropic ossification of traumatized muscle, angioid streaks, diabetes mellitus type II, cardiovascular disorder, or atherosclerosis.

The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine preparation for treating chronic arteriosclerosis obliterans of the limbs. The traditional Chinese medicine preparation is prepared from the following traditional Chinese medicine raw materials in parts by weight: 20-30 parts of panax notoginseng, 20-30 parts of danshen root, 20-30 parts of all-grass of khas aletris, 20-30 parts of manyinflorescaned sweetvetch root, 15-20 parts of rhizome of common dysosma, 15-20 parts of all-grass of manystamen balanophora, 15-20 parts of pinnapectinata, 15-20 parts of herb of Chinese alyxia, 10-15 parts of hamilton's phlegmariurus, 10-15 parts of summer grape, 10-15 parts of root of artocarpus hypargyreus hance, 5-10 parts of longstalk condorvine, 5-10 parts of herb of henbit deadnettle, 5-10 parts of fruit of spinach, 3-5 parts of manyprickle acanthopanax root, 3-5 parts of codonacanthus pauciflorus and 3-5 parts of winterberry euonymus herb. The traditional Chinese medicine preparation disclosed by the invention has the advantages that traditional Chinese medicines adopted by the preparation can meet the regulations of Pharmacopoeia of the People's Republic of China, and are safe and reliable; various medicines are combined to play roles in invigorating qi and eliminating evil, nourishing the liver and kidneys, breaking blood and eliminating blood stasis, activating blood and dredging collaterals, and dredging the meridians; and the traditional Chinese medicine preparation has the characteristics of accurate curative effect, quick action, high cure rate and no toxic or side effects on treatment of chronic arteriosclerosis obliterans of the limbs.

The invention discloses a traditional Chinese medicine composition for treating artery thrombosis obliterans. The composition is prepared by the following crude drugs according to a certain weight matching ratio: radix aconiti lateralis preparata, astragalus membranaceus, cassia twig, radix paeoniae alba, peach kernel, safflower carthamus, hirudo, immature bitter orange, rheum officinale, herba asari and the like. The traditional Chinese medicine composition has the remarkable treatment effect to artery thrombosis diseases, especially limb arteriosclerosis obliterans.

The invention belongs to the field of traditional Chinese medicines and particularly relates to a traditional Chinese medicine preparation for treating chronic arteriosclerosis obliterans and a preparation method thereof. The traditional Chinese medicine preparation is prepared from following raw materials, by weight, 25-35 parts of angelica sinensis, 25-35 parts of rhizoma chuanxiong, 25-35 parts of red peony roots, 25-35 parts of folium artemisiae argyi, 25-35 parts of notopterygium roots, 25-35 parts of pericarpium zanthoxyli, 25-35 parts of radix angelicae, 25-35 parts of raw radix aconite lateralis, 25-35 parts of raw arisaema erubescens, 10-20 parts of dry ginger, 10-20 parts of flos carthami, 10-20 parts of carcuma longa, 10-15 g of curcuma zedoary and 5-10 parts of manyprickle acanthopanax roots. The traditional Chinese medicines satisfy the specifications in Chinese pharmacopoeia, are safe and reliable, and are combined together to achieve the effects of celaring heat and detoxifying body, boosting qi and nourishing yin, activating blood and resolving stasis, solidifying kidney and relieving thirsty. The preparation has definite curative effects on the chronic arteriosclerosis obliterans, is quick in effects, is high in curative ratio and is free of side effects.

The invention discloses a compound cell preparation, a preparation method and application of the preparation. The preparation comprises autologous platelet rich plasma (PRP), autologous adipose derived stromal cells (ADSCs) and endothelial progenitor cells (EPCs) of ADSC sources. The preparation method comprises the following steps that fat is collected, and adipocyte is separated; the adipocyte is cultured through an ADSC culture medium to obtain P2-generation autologous ADSCs; the P2-generation autologous ADSCs are cultured through an EPC culture medium to obtain EPCs of P0-generation ADSC sources; anticoagulation peripheral blood of a receptor is collected and centrifuged to obtain PRP, and the application of the compound cell preparation in the medicine for treating lower extremity arteriosclerosis obliterans due to diabetes is achieved. The compound cell preparation has the advantages that the EPC culture medium is adopted for inducing the ADSCs to be cultured, the EPCs with the expression percentage of CD133 as 68.72+ / -11.60% and the expression percentage of vWF as 75.91+ / -9.83% are obtained, bone marrow or mobilized peripheral blood does not need to be collected, and after affected parts of patients with lower extremity arteriosclerosis obliterans due to diabetes are injected with the preparation, the limb pain feeling and cold feeling can be lowered, and the new generation rate of collateral vessels is 100%; the total survival rate is 78.12%, the limb salvage survival rate is 68.00%, and the survival life of artificial limbs of the patients can be effectively prolonged.

The invention belongs to the field of traditional Chinese medicines and particularly relates to a traditional Chinese medicine drug for treating chronic arteriosclerosis obliterans. The traditional Chinese medicine drug is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 20-30 parts of pseudo-ginseng, 20-30 parts of salviae miltiorrhizae, 20-30 parts of polygonatum kingianum, 20-30 parts of astragalus, 15-20 parts of kadsura root-barks, 15-20 parts of aleuritopteris argentea, 15-20 parts of Miscanthus sinensis Anderss, 15-20 parts of selaginella tamariscina, 10-15 parts of atriplex repens, 10-15 parts of herminium monorchis, 10-15 parts of tendrilleaf solomonseal rhizome, 5-10 parts of cynanchum mooreanum Hemsl., 5-10 parts of lamium amplexicaule, 5-10 parts of tribulus terrestris, 3-5 parts of acanthopanax, 3-5 parts of codonacanthus pauciflorus and 3-5 parts of euonymus bungeanus. The traditional Chinese medicine drug has the advantages that the used traditional Chinese medicines meet provisions of the Pharmacopoeia of the People's Republic of China, and are safe and reliable. The medicines cooperatively achieve effects of tonifying qi and eliminating evil, nourishing livers and kidneys, breaking stagnant and eliminating blood stasis, promoting blood circulation to remove meridian obstruction and dredging the channels, so that the traditional Chinese medicine drug for treating chronic arteriosclerosis obliterans has the characteristics of being exact in curative effect, quick in effect-taking, high in cure rate, free of side effect, and the like.

The invention relates to an externally washing lower limb arteriosclerosis obliterans treating traditional Chinese medicine composition. The externally washing lower limb arteriosclerosis obliterans treating traditional Chinese medicine composition is composed of, by weight, 10-14 g of herba schizonepetae, 13-17 g of herba lycopodii, 8-12 g of radix aconiti sinensis preparata, 13-17 g of flos carthami, 8-12 g of herba speranskiae tuberculatae, 13-17 g of radix saposhnikoviae, 13-17 g of fructus liquidambaris, 13-17 g of cortex illicii, 3-7 g of herba asari, 8-12 g of rhizome smilacis glabrae,8-12 g of folium artemisiae, 8-12 g of radix aconiti agrestis preparata, 8-12 g of radix clematidis and 28-32 g of herba erodii seu geranii.

The invention belongs to the technical field of traditional Chinese medicine and particularly relates to a Chinese herba preparation for treating acro-arteriosclerosis obliterans and a preparation method thereof. The Chinese herba preparation is made of astragalus membranaceus, codonopsis pilosula, red-rooted salvia roots, moutan bark, loofa sponge, caulis spatholobi, houttuynia cordata, houttuynia cordata, seaweed and oysters. The Chinese herba preparation is remarkably effective in promoting the blood circulation, removing the blood stasis, inducing menstruation, reliving menalgia, tonifying qi and regulating the vital energy, a good therapeutic effect for treating the acro-arteriosclerosis obliterans, in particular to the blood stasis type acro-arteriosclerosis obliterans, is achieved, the medicine side effect is little, relapse is not prone to occurring, and the significant clinic promotion value is achieved.

The invention is concerned with use of oral inorganic pyrophosphate for preventing and / or reducing tissue calcification, particularly soft tissue calcification, and / or diseases or disorders characterized by low plasma PPi levels, as, e.g., occurs in chronic kidney disease (CKD), end-stage renal disease (ESRD), generalized arterial calcification of infancy (GACI), Pseudoxanthoma elasticum (PXE), Arterial Calcification Due to Deficiency of CD73 (ACDC), Ehlers-Danlos syndrome, arteriosclerosis obliterans, venous calcifications, crystal deposition disorders, calcification resulting from neurological disorders, calcinosis universalis, calcinosis circumscripta, scleroderma, dermatomyositis, systemic lupus erythematosus, hyperparathyroidism, neoplasms, milk-alkali syndrome, hypervitaminosis D, tumoral calcinosis, hypophosphatemic rickets, ossification of the posterior longitudinal ligament of the spine, myocardial ischemia, joint calcification, heterotropic ossification of traumatized muscle, angioid streaks, diabetes mellitus type II, cardiovascular disorder, or atherosclerosis.

The invention relates to the technical field of traditional Chinese medicines, and discloses a Yiwangao ointment and a preparation method thereof. The Yiwangao ointment disclosed by the invention is prepared by decocting radix astragali, Chinese angelica, ground beetle, radix aconiti, radix aconiti kusnezoffii, cochinchina momordica seed, centipede, frankincense, myrrh, dragon's blood, yellow wax, minium and sesame oil. In the invention, multiple pure natural raw materials are selected as the components of the compound traditional Chinese medicine Yiwangao ointment; the Yiwangao ointment is prepared by decocting with a unique process, realizes a remarkably curative effect on curing symptoms such as angiitis, arteriosclerosis obliterans, diabetic foot, deep and shallow venous thrombus, venous ulcer, various bone diseases, lumbar disc herniation, gout, synovitis, stubborn dermatitis, malignant sore, burn, frostbite and the like, and has the advantages of convenience in use, low cost, remarkable curative effect and the like.

The invention belongs to the technical field of medicines and particularly relates to a traditional Chinese medicine composition for treating damp-heat toxin-predominance type early diabetic lowerlimb arteriosclerosis obliterans. The traditional Chinese medicine composition is composed of the following traditional Chinese medicines in parts by weight: 5-13 parts of symplocos sumuntia, 6-14 parts of mussaenda pubescens, 11-19 parts of vitis amurensis, 11-19 parts of rabdosia tenuifolia, 11-19 parts of ficus lyrata, 5-13 parts of aralia apioides, 5-13 parts of disporopsis longifolia, 6-14 parts of scrophularia henryi, 4-8 parts of oxhide gelatin, 6-14 parts of paraphlomis javanica, 5-13 parts of alyxia sinensis, 4-8 parts of whole herb of phlegmariurus hamiltonii, 5-13 parts of aralia undulata, 5-13 parts of hypericum monanthemum Hook. f. et Thorns. ex Dyer, 4-8 parts of whitewood, 6-14 parts of sterculia monosperma shell and 4-8 parts of liquorice. According to the traditional Chinese medicine composition provided by the invention, all medicines are used together to achieve the effects of clearing heat, promoting diuresis, detoxifying, reinforcing qi, nourishing yin, and promoting blood circulation to remove meridian obstruction, and the traditional Chinese medicine composition has the effects of resisting platelet aggregation, improving blood viscosity and vascular dilation, increasing blood flow velocity and improving clinical symptoms and blood circulation of lower limbs.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to an external plaster for dredging veins and application and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from leech, scorpion, centipede, angelica sinensis, radix scrophulariae, coix seed, golden cypress, honeysuckle, astragalus membranaceus, liquorice and the like, and the ointment disclosed by the invention can be used for treating lower limb deep venous thrombosis, thrombophlebitis, thromboangiitis obliterans, lower limb arteriosclerosis obliterans and the like, and has the advantages of being easy to attach, and easy to penetrate human skin; and the percutaneous absorption is realized, so that the effect is fully exerted. Compared with oral medicines and injections, the traditional Chinese medicine composition has the advantages of small toxic and side effects, direct lesion, quick absorption, instant effect, wide application range and no obvious contraindication.

A traditional Chinese medicine composition for treating early arteriosclerotic obliterative disease of diabetic extremities. The following traditional Chinese medicine proportioning formula is adopted: 4 parts of cockles, 8 parts of Digupi, 8 parts of Echeveria, 8 parts of asparagus, and 8 parts of Xiaokecao 10 parts of heterophylla, 13 parts of stamen grass, 13 parts of trichosanthes, 8 parts of gynostemma, 15 parts of vermicelli, 6 parts of coptis, 6 parts of Puyan root, 5 parts of Polygonatum odoratum, 8 parts of gentian, and 10 parts of zhidan , 13 parts of Shenjincao, 8 parts of Rehmannia glutinosa. Compared with the prior art, the present invention has the advantages of good therapeutic effect, high cure rate, no side effect, no strict requirement on diet, simple preparation method and the like.