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Folic acid dropping pill and its preparation method

A technology of folic acid and dripping pills, which is applied in the field of pharmacy, can solve the problems of affecting the clinical efficacy of drugs, low release rate of ingredients, and low bioavailability, and achieve the effects of avoiding the first-pass effect of the liver and intestines, accelerating dissolution and absorption, and high bioavailability Effect

Inactive Publication Date: 2008-01-16
BEIJING HUAANFO BIOMEDICAL RES CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] (1) The disintegration rate is slow, and the release rate of the active ingredient is low;
[0010] (2) Poor absorption and low bioavailability often affect the clinical efficacy of the drug;
[0011] (3) First-pass effect: First-pass effect, also known as the first checkpoint effect, means that after oral drugs are absorbed in the gastrointestinal tract, they first pass through the portal vein to the liver, and then enter the systemic circulation.
Conventional oral preparations are mostly absorbed in the gastrointestinal tract due to their own reasons, which is prone to first-pass effect and reduces the active ingredients;
[0012] (4) It is inconvenient for children, the elderly, bedridden patients and patients with dysphagia to take

Method used

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  • Folic acid dropping pill and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Prescription 1000 capsules

[0056] Folic acid 0.4g

[0057] Macrogol 4000 3g

[0058] Macrogol 6000 7.5g

[0059] Strawberry essence 0.1g

[0060] Preparation:

[0061] Weigh folic acid and polyethylene glycol according to the prescription amount, mix evenly, heat to 85°C, stir and melt, so that the folic acid is completely dissolved; then add strawberry essence and corrective agent, and mix well. Keeping the temperature, move the molten mixture into the dripping pill machine, and use a dropper with a diameter of 1 mm to drip at a temperature of 85°C; the liquid medicine is dropped into liquid paraffin at -10°C, solidified for 30 to 40 minutes, and filtered out Dropping pills, remove the liquid paraffin, select the pills, and make 1000 dropping pills. Each drop pill weighs 11mg and contains 0.4mg of folic acid.

Embodiment 2

[0063] Prescription 1000 capsules

[0064] Folic acid 0.8g

[0065] Macrogol 4000 6g

[0066] Macrogol 6000 15g

[0067] Orange flavor 0.1g

[0068] Preparation:

[0069] Weigh folic acid and polyethylene glycol according to the prescription amount, mix evenly, heat to 85°C, stir and melt, so that the folic acid is completely dissolved; then add orange essence and corrective agent, and mix well. Keeping the temperature, move the molten mixture into the dripping pill machine, and use a dropper with a diameter of 1 mm to drip at a temperature of 85°C; the liquid medicine is dropped into liquid paraffin at -10°C, solidified for 30 to 40 minutes, and filtered out Dropping pills, remove the liquid paraffin, select the pills, and make 1000 dropping pills. Each drop pill weighs 21.9mg and contains 0.8mg of folic acid.

Embodiment 3

[0071] Prescription 1000 capsules

[0072] Folic acid 1.0g

[0073] Macrogol 4000 8g

[0074] Macrogol 6000 12g

[0075] Preparation:

[0076] Weigh folic acid and polyethylene glycol according to the prescription amount, mix evenly, heat to 85°C, stir and melt, so that the folic acid is completely dissolved; keep the temperature, move the molten mixture into the dripping pill machine, and use a dripper with a diameter of 1mm in the Dropping is carried out at a temperature of 85°C; the drug solution is dropped into liquid paraffin at -10°C, solidified for 30 to 40 minutes, filtered out to remove the liquid paraffin, and selected to obtain 1,000 drop pills. Each drop pill weighs 21mg and contains 1.0mg of folic acid.

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PUM

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Abstract

The invention relates to an oral folacin pill preparation which contains drug and expients; wherein the drug contains folacin and the excipient is one of or mixture of more than two (including two) of polyethyleneglycol, magnesium stearate, stearic acid, sodium stearate, poloxamer, polyoxyethylene dehydrous sorbitol fatty acid ester, polyoxyethylene (40) monostearate (S-40), sucrose fatty ester and glycerogelatin. The invention also relates to the preparation method of the folacin pill preparation and the purpose of the folacin pill preparation in preparation of drug for treating hyperhomocysteinemia. The folacin pill preparation provided in the invention, belonging to the pharmaceutical field has the advantages of full dissolution of the drug, quick effect and improvement of human bioavailability.

Description

technical field [0001] The invention relates to an oral folic acid drop pill preparation. The drop pill preparation is composed of medicine and auxiliary materials, the medicine contains folic acid, and the auxiliary materials are polyethylene glycol, magnesium stearate, stearic acid, sodium stearate, poloxamer, polyoxyethylene sorbitan fatty acid ester, One or a mixture of two or more of polyoxyethylene (40) monostearate, sucrose fatty acid ester and glycerin gelatin. The invention also relates to a preparation method of the folic acid drop pill preparation, and an application of the folic acid drop pill preparation in preparing medicine for treating hyperhomocysteinemia. The present invention belongs to the field of pharmacy. Background technique [0002] Atherosclerosis, coronary heart disease, stroke and other cardiovascular and cerebrovascular diseases, in addition to the relevant risk factors studied in the past, in recent years, domestic and foreign scholars have fo...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61K31/714A61K9/20A61P9/10A61P7/00
Inventor 李华王文艳于多戴成祥徐希平
Owner BEIJING HUAANFO BIOMEDICAL RES CENT
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