6 results about "Neural tube defect" patented technology

The invention relates to a marker for detecting and / or diagnosing 21-trisomy syndrome, 18-trisomy syndrome and neural tube defects and application of the marker, and belongs to the technical field of medical detection. The marker provided by the invention is selected from one or more of maternal serum D-dimer (D-D), pregnancy related plasma protein A (PAPP-A) and free human chorionic gonadotropin beta subunit (Free beta-hCG). The D-D + PAPP-A + Free beta-hCG model provided by the invention has the highest diagnostic value for 21-trisomy syndrome (DS) and 18-trisomy syndrome (ES), and the combination of D-D and PAPP-A and / or Free beta-hCG can improve the diagnostic value, diagnostic sensitivity and screening effect for neural tube defects (NTD). A new marker and a screening scheme are provided for simultaneously monitoring and diagnosing DS, ES or NTD fetuses of early pregnancy pregnant women in the clinical early stage.

The invention discloses a fetal image parameter automatic extraction system for spinal cord neural tube malformation screening, and relates to the technical field of medical image processing, and the system comprises a fetal spine collection module which is used for collecting fetal spine structure data, and carrying out the preprocessing of the collected data; the fracture structure identification module is used for constructing a fracture boundary point set, carrying out quantitative evaluation on the complexity of a fracture geometric structure and judging the complexity level of fracture boundary points; the fissure position correction module is used for quantifying the deviation degree of the fissure scale relative to the spinal canal size and executing position correction operation in combination with the complex grade; and the structure anomaly analysis module is used for performing quantitative evaluation on the sudden change intensity of the ridge crack geometric structure and generating a ridge crack basic parameter set and a ridge crack image structured analysis data set. The problems that in existing fetal spine image processing, fracture boundaries cannot be accurately extracted, so that fracture structure judgment is unstable, and spinal cord neural tube malformation screening lacks a reliable quantization parameter basis are solved.

The invention discloses a compound oral film preparation for nerve cell protection. The compound oral film preparation comprises a nerve protection type natural product, a compound lipid compound containing phosphoric acid, vitamin or a vitamin-like compound, a nano lipid carrier, a film forming material and pharmaceutically acceptable auxiliary materials. The preparation solves the problems of low absorption and metabolism efficiency and insufficient synergistic effect caused by physicochemical property difference among multiple components, and has the characteristics of convenience in taking and high safety. In-vitro cell experiments show that the film agent can significantly promote the growth of nerve cells, has a significant nerve protection effect, is helpful for treating neurodegenerative diseases and promoting brain health, and has a great application prospect in the aspects of improving memory and attention, and preventing memory degeneration or neural tube malformation.

The application provides a detection system for genetic risk assessment of neural tube defects, and relates to the technical field of bioinformatics. The system comprises: obtaining genomic sequencing data of a to-be-detected individual, performing targeted filtering based on a preset NTD-related gene set, and screening out rare pathogenic variants located in the gene set, MAF satisfying a preset frequency threshold, and predicted to have biological pathogenicity; then, the total number of the rare pathogenic variants is counted to obtain a mutation load value, which is compared with a preset determination threshold, and a risk assessment result is output. The application effectively removes the whole genome background noise by limiting the gene set range and quantifying the cumulative effect of rare pathogenic variants, breaks through the limitations of narrow coverage of traditional single gene detection and lag of imaging diagnosis, significantly improves the specificity and sensitivity of neural tube defect diagnosis, and can realize precise risk early warning in early pregnancy or before embryo implantation.

The present invention relates to the field of applied basic medical research, specifically to a method for inducing a zebrafish neural tube defect model using all-trans retinoic acid (ATRA). This invention establishes, for the first time, a zebrafish model of neural tube defects induced by all-trans retinoic acid (ATRA), providing a new zebrafish model for studying the mechanisms and treatments of neural tube defects caused by early pregnancy ATRA. The technical problem addressed by this invention is to establish a convenient, time-saving method that allows for direct in vitro observation of the embryonic neural tube development process. This novel method for inducing a zebrafish neural tube defect model has a high embryonic malformation rate and a low mortality rate.

The present invention discloses microRNAs as molecular markers for noninvasive prenatal screening of neural tube defects (NTDs) and their applications, belonging to the field of pharmaceutical biotechnology. The invention provides molecular markers for noninvasive prenatal diagnosis of NTDs and their applications. The molecular markers, composed of one or more miRNAs, hsa-miR-223, hsa-miR-187, and hsa-let-7d, can be used for prenatal screening of NTDs, providing new targets for treatment and possessing significant clinical significance.