30results about How to "Increase or decrease stability" patented technology

The present invention discloses modified neurotoxins with altered biological persistence. In one embodiment, the modified neurotoxins are derived from Clostridial botulinum toxins. Such modified neurotoxins may be employed in treating various conditions, including but not limited to muscular disorders, hyperhidrosis, and pain.

The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen independent prostate cancer. The invention further relates to compositions and methods which can be used to identify and treat prostate cancer based on these novel androgen receptor splice variants, as well as methods for screening agents which modulate the activity and / or expression of the androgen receptor splice variants. Vectors, host cells and recombinant methods for producing the same and transgenic animals are also provided.

The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen independent prostate cancer. The invention further relates to compositions and methods which can be used to identify and treat prostate cancer based on these novel androgen receptor splice variants, as well as methods for screening agents which modulate the activity and / or expression of the androgen receptor splice variants. Vectors, host cells and recombinant methods for producing the same and transgenic animals are also provided.

The present invention relates to a mobile vehicle or wheelchair having the ability to provide stabilized transport to at least one individual on a variety of surfaces, slopes and / or terrains. In one aspect, the invention provides adjustment features allowing the mobile vehicle or wheelchair to accommodate individuals of various sizes and shapes. For example, the invention comprises a seat and an adjustable footrest which can be lengthened or shortened to accommodate different size individuals, including children. In one embodiment the distance between the footrest and the seat can be increased or decreased to accommodate different leg lengths of different individuals. The mobile unit or wheelchair of the invention may travel across smooth and very rough surfaces, slopes of varying or different angles and various outdoor terrains (including grassy, rocky, sandy, muddy and / or hilly terrains). In one aspect of the invention, the height of any part of the unit or the overall height of the device may be adjusted preferably to raise or lower the center of gravity. For example, the height of the device may be lowered to provide more stable transportation. In another aspect, the device may be adjusted to increase or decrease the size of the footprint (or any part of the footprint) of the device. For example, the footprint of the device may be enlarged to provide more stable transportation. Preferably, both the height of the device (or any part of the device) and the size of the footprint (or any part of the footprint) may be adjusted preferably to provide more stability.

The present invention relates to a mobile vehicle or wheelchair having the ability to provide stabilized transport to at least one individual on a variety of surfaces, slopes and / or terrains. In one aspect, the invention provides adjustment features allowing the mobile vehicle or wheelchair to accommodate individuals of various sizes and shapes. For example, the invention comprises a seat and an adjustable footrest which can be lengthened or shortened to accommodate different size individuals, including children. In one embodiment the distance between the footrest and the seat can be increased or decreased to accommodate different leg lengths of different individuals. The mobile unit or wheelchair of the invention may travel across smooth and very rough surfaces, slopes of varying or different angles and various outdoor terrains (including grassy, rocky, sandy, muddy and / or hilly terrains). In one aspect of the invention, the height of any part of the unit or the overall height of the device may be adjusted preferably to raise or lower the center of gravity. For example, the height of the device may be lowered to provide more stable transportation. In another aspect, the device may be adjusted to increase or decrease the size of the footprint (or any part of the footprint) of the device. For example, the footprint of the device may be enlarged to provide more stable transportation. Preferably, both the height of the device (or any part of the device) and the size of the footprint (or any part of the footprint) may be adjusted preferably to provide more stability.

One embodiment of a lateral roll simulating assembly is provided which is adapted to attach to existing rowing exercise machines. It permits the user to experience various levels of physiological disequilibrium when a lack of proper balance control induces a sideways tipping action during a rowing workout. This facilitates the desirable and advantageous development of correct proprioceptive balance response using appropriate core musculature while practicing the rowing motion on a suspended rowing exercise machine. The apparatus comprises two floor-mounted members secured to each end of a rowing exercise machine that support the rowing exercise machine in a suspended condition. This assembly simulates lateral instability around the metacenter of any of a variety of rowing shells on water by allowing the rowing exercise machine to roll freely around a variety of longitudinal axes. Other embodiments are described and shown.

The invention discloses a full-automatic degassing machine, comprising a degassing barrel (2), a slurry inlet (1), a slurry outlet (6), a stirring and crushing device (3) and a motor. The invention is characterized in that the full-automatic degassing machine also comprises an air cavity (7), an air inlet (8), an oil gas suction inlet (9), a lifting support sliding rod (21), a guide rail locatingplate (12), a double spindle lifting cylinder (24) and a brake friction plate (30), and a first ultrasonic wave probe (15), a second ultrasonic wave probe (16), a slurry blocking detection device (25) and an automatic drainer (26), and the double spindle lifting cylinder (24), a braking cylinder (28), the slurry blocking detection device (25), the motor (13), the first ultrasonic wave probe (15) and the second ultrasonic wave probe (16) are all connected with an electric control device (31). The full-automatic degassing machine disclosed by the invention has a reasonable design, a simple structure, economy and practicability, convenience in operation, good degassing efficiency, high efficiency, long service life and simplicity in mounting and dismounting.

One embodiment of a lateral roll simulating assembly is provided which is adapted to attach to existing rowing exercise machines. It permits the user to experience various levels of physiological disequilibrium when a lack of proper balance control induces a sideways tipping action during a rowing workout. This facilitates the desirable and advantageous development of correct proprioceptive balance response using appropriate core musculature while practicing the rowing motion on a suspended rowing exercise machine. The apparatus comprises two floor-mounted members secured to each end of a rowing exercise machine that support the rowing exercise machine in a suspended condition. This assembly simulates lateral instability around the metacenter of any of a variety of rowing shells on water by allowing the rowing exercise machine to roll freely around a variety of longitudinal axes. Other embodiments are described and shown.

The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen independent prostate cancer. The invention further relates to compositions and methods which can be used to identify and treat prostate cancer based on these novel androgen receptor splice variants, as well as methods for screening agents which modulate the activity and / or expression of the androgen receptor splice variants. Vectors, host cells and recombinant methods for producing the same and transgenic animals are also provided.

The invention discloses a goods sorting system and a sorting method. The goods sorting system comprises a feeding device, a transmitting device, a pushing device, a kick-off device and a sorting bin. The sorting bin comprises a plurality of bin bodies; the feeding device, the transmitting device, the pushing device and the kick-off device are sequentially connected; the transmitting device is a U-shaped rotation channel which comprises a feeding line and a blanking line; the feeding device is used for conveying goods onto the feeding line; the pushing device is connected with the feeding line and the blanking line, and is used for pushing goods detected on the feeding line to the blanking line; the kick-off device is used for kicking off each goods on the blanking line into one bin body; the sorting bin is located under the kick-off device; the goods sorting system further comprises a controller; and the feeding device, the pushing device and the kick-off device are controlled by the controller. The goods sorting system is compact in structure and can realize automatic sorting of goods.

The invention features a novel gene encoding methionine synthase reductase. The invention also features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects, cardiovascular disease, Down's Syndrome or cancer. The invention also features therapeutic methods for treating and / or reducing the risk of cardiovascular disease, Down's Syndrome, cancer, or neural tube defects. Also provided are the sequences of the human methionine synthase reductase gene and protein and compounds and kits for performing the methods of the invention.

The invention features a novel gene encoding methionine synthase reductase. The invention also features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects, cardiovascular disease, Down's Syndrome or cancer. The invention also features therapeutic methods for treating and / or reducing the risk of cardiovascular disease, Down's Syndrome, cancer, or neural tube defects. Also provided are the sequences of the human methionine synthase reductase gene and protein and compounds and kits for performing the methods of the invention.

A method of ionising a sample is disclosed comprising performing an initial experiment comprising: (i) adding one or more reagents to an analyte sample; (ii) varying the composition and / or concentration of the one or more reagents; (iii) ionising the analyte sample including the one or more reagents; (iv) determining the composition and / or concentration of the one or more reagents which results in a desired, improved or optimised ionisation or other condition or parameter for one or more analytes of interest; and (v) determining one or more first retention times or one or more first retention time windows for the one or more analytes of interest. The method then further comprises separating an analyte sample using a first separation device and during the course of a single experimental run or acquisition varying the composition and / or concentration of one or more reagents which are added to an eluent which emerges from the first separation device. The composition and / or concentration of the one or more reagents which are added to the eluent is varied at the one or more the first retention times or during the one or more the first retention time windows so that an ionisation or other condition or parameter for the one or more analytes of interest is as desired or is improved or optimised.

The invention provides farmyard manure granules and a preparation method thereof. The farmyard manure granules comprise the following raw materials by weight: 50 to 60 parts of human excrement, 30 to40 parts of pig manure, 10 to 20 parts of a cake fertilizer, 10 to 20 parts of soybean straw, 10 to 15 parts of urea formaldehyde, 10 to 15 parts of calcium superphosphate, 15 to 20 parts of modifiedvermiculite, 15 to 20 parts of humic acid, 2 to 3 parts of pericarpium papaveris powder, 6 to 10 parts of a biological fermentation inoculum, 8 to 10 parts of alum, 2 to 3 parts of radix stemonae, 2 to 3 parts of sodium fluorosilicate and 30 to 50 parts of an auxiliary material. The farmyard manure granules provided by the invention can achieve the purpose of killing bacteria and insects in farmyard manure without undergoing the process of high-temperature fermentation; a decomposition promoter in a fertilizer can promote decomposition of an organic fertilizer and facilitates absorbing the fertilizer for a crop; and through mixing of the farmyard manure and a chemical fertilizer, the synergistic effect of the fertilizer can be effectively enhanced.

It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.

A method of ionizing a sample is disclosed comprising performing an initial experiment comprising: (i) adding one or more reagents to an analyte sample; (ii) varying the composition and / or concentration of the one or more reagents; (iii) ionizing the analyte sample including the one or more reagents; (iv) determining the composition and / or concentration of the one or more reagents which results in a desired, improved or optimized ionization or other condition or parameter for one or more analytes of interest; and (v) determining one or more first retention times or one or more first retention time windows for the one or more analytes of interest. The method then further comprises separating an analyte sample using a first separation device and during the course of a single experimental run or acquisition varying the composition and / or concentration of one or more reagents which are added to an eluent which emerges from the first separation device. The composition and / or concentration of the one or more reagents which are added to the eluent is varied at the one or more the first retention times or during the one or more the first retention time windows so that an ionization or other condition or parameter for the one or more analytes of interest is as desired or is improved or optimized.

A game system including a game controller and game machine that executes a game program. The game controller including a balance platform supported at its center and under its periphery by an inflatable bladder, an air pressure source, a dual-axis accelerometer measuring tilt of the balance platform, a control valve, and an air pressure sensor measuring air pressure of the inflatable bladder. The game machine receives real time measures of the air pressure of the inflatable bladder and the tilt of the balance platform, displays on a screen a game player's location in a game space generated by the game program, based on the measures of the tilt, and changes the air pressure of the inflatable bladder during game play in response to the game program generating an interaction between the game player's location and a location of an interactive graphic image created by the game program.

The invention discloses a movable photovoltaic power generation assembly and a use method, relates to the technical field of photovoltaic power generation, and aims to solve the problem of low safetycaused by a single structure of an existing movable photovoltaic power generation assembly. A first supporting frame is arranged on one side of the connecting piece, a second supporting frame is arranged on the other side of the connecting piece, a frame body rotating shaft is arranged at the joint of the first supporting frame and the second supporting frame, a rotating wheel frame is arranged below the first supporting frame and the second supporting frame, and a rotating wheel is arranged at the lower end of the rotating wheel frame. A controller is arranged on the front end face of the bottom plate, a photovoltaic inverter is arranged on one side of the controller, a bearing is arranged on the upper end face of the base, a rotating table is arranged at the upper end of the bearing, a supporting frame is arranged on the upper end face of the rotating table, and a connecting bottom plate is arranged above the supporting frame. And a second electric hydraulic push rod is arranged below the connecting bottom plate, and a sliding groove is formed in the lower surface of the second electric hydraulic push rod.

The invention discloses an M-bit binary MAX phase material as well as a preparation method and application thereof. The molecular formula of the MAX phase material is represented as (Mx, M'y) n + 1AXn, 0lt; xlt; 1, 0lt; yt; Yt; x + y = 1, M and M'are respectively Ta, Sc, Hf, V, Nb, Mo, Zr, Cr, Ti, Mn or Y elements, M is different from M ', A is Sn, Al, Zn, Cu, Ge, Cd, Ga, In, Pb, S, Si or P elements, X is C and / or N elements, and n is 1, 2, 3 or 4. The preparation method is free of tedious processes and easy to implement, related elements of the components can be regulated and controlled according to requirements and application, members of the MAX phase material system are expanded, possibility is provided for obtaining more M-bit binary two-dimensional MXenes materials, and the MAX phase material has potential application prospects in the fields of ultrahigh temperature, biomedicine, energy and the like.

The invention discloses a side slope deviation monitoring device based on a forest land side slope fixing and stabilizing technology. The device comprises a seat frame, a base frame and a monitoring device. The base frame is arranged at the top end of the seat frame; a monitoring device is arranged at the top end of the base frame; a control box matched with the base frame is arranged in the center of the top end surface of the seat frame; partition plates are bilaterally and symmetrically arranged on the top wall of the inner cavity of the seat frame; the inner cavity of the seat frame is divided into a stabilizing cavity and two moving cavities by the partition plate; two pairs of second sliding rails are symmetrically arranged on the left side wall and the right side wall of the stabilizing cavity, a second lifting plate is arranged on each pair of second sliding rails, the top ends of the second lifting plates are connected with the control box through second telescopic rods, stabilizing plates are arranged at the bottom ends of the second lifting plates, and a plurality of fixing anchor rods are evenly arranged at the bottom ends of the stabilizing plates; the second telescopic rod is controlled by the second hydraulic cylinder to extend out and descend, so that the second lifting plate is pushed to descend along the second sliding rail, the fixing anchor rod is inserted into soil, the stability of the seat frame is improved or reduced and the stability of the whole device is guaranteed.

The invention provides a self-luminous anti-collision device for isolating road and bridge construction. The self-luminous anti-collision device comprises a base. A moving trolley is fixedly mounted at the bottom of the base; anti-collision barrels are uniformly arranged in a spaced manner at the front end edge and the back end edge of a top plane of the base, separately; a light-emitting mechanism is rotatably connected to a supporting seat at the upper end of the anti-collision barrel at the front end through a pin roll; a rotating shaft is transversely connected to the middle of the base ina penetrating manner; and a locking mechanism is fixedly mounted at the tail end of the left end of the rotating shaft, and the lower end of the locking mechanism is fixedly mounted on the moving trolley. According to the self-luminous anti-collision device for isolating road and bridge construction, as bright battens are embedded onto the front end surface and the back end surface of the base and uniformly spaced V grooves are also transversely formed in the bright battens, lamplight irradiating on the bright battens can reflect to remind vehicle drivers. As the V grooves are formed, the reflecting angles of the lamplight can be increased.

The invention relates to a lifting device for electric power overhaul. The lifting device comprises a base, a lifting frame and guide rails, supporting legs are arranged on the lower side of the base,a hydraulic oil pump is arranged on the inner sides of the supporting legs, a driving motor is arranged on the front sides of the supporting legs, rolling wheels are arranged at the lower ends of thesupporting legs, the driving motor can drive the rolling wheels to rotate, the lifting frame is arranged on the upper portion of the base, and a hydraulic cylinder is arranged in the lifting frame. The hydraulic cylinder is driven by the hydraulic oil pump, a carrying table is arranged on the upper portion of the lifting frame, a controller is arranged in the carrying table, and the guide rails are arranged on the lower portion of the base. When the lifting device is used, a maintainer enters the carrying table and controls the lifting frame to reach a proper maintenance position through thecontroller; after the maintenance work is completed and the position needs to be adjusted, the driving motor needs to be controlled by the controller to operate to drive the base to move along the guide rails to reach other maintenance positions, and the lifting frame does not need to descend during movement, so that the working efficiency is greatly improved; and the lifting device has the advantages of being convenient to use, easy to control, wide in moving range and high in safety performance.

The invention provides a multifunctional material pushing frame for a construction site building. The multifunctional material pushing frame comprises support frames, connecting frames, connecting plates, a conveying belt, a motor and a switch. Two layers of support frames are arranged. The connecting frames are arranged at the upper ends of the support frames and are all further controlled by thesupport frames. The conveying belt is arranged on the inner sides of the connecting frames and is movably connected with the connecting frames. The connecting plates are arranged on the upper left and lower left of the front faces of the connecting frames, and the connecting plates and the connecting frames are welded tightly. Every three connecting frames form a set, and each connecting frame issupported independently by the corresponding support frame. Each connecting frame is supported independently by the corresponding support frame, thus when the pushing frame needs to be moved overall,the contact parts of the support frames and the connecting frames are separated, the support frames and the connecting frames are lifted correspondingly, so that when overall moving is needed, disassembly procedures are reduced, a fast moving effect is achieved, and the multifunctional material pushing frame is suitable for production and use of building equipment and has good development prospects.

The invention discloses a compound manure fertilizer and a preparation method thereof. The compound manure fertilizer is composed of raw materials including, by weight part, 50-60 parts of human manure, 30-40 parts of chicken manure, 10-15 parts of urea, 5-10 parts of phosphate fertilizer, 15-20 parts of vermiculite, 3-5 parts of camphor, 15-20 parts of humic acid, 2-3 parts of pericarpium papaveris powder, 3-5 parts of biological microbial agent, 2-3 parts of chlorpyrifos, 2-3 parts of abamectin, 80-100 parts of auxiliaries and 6-10 parts of decomposition accelerant. The compound manure fertilizer is comprehensive in fertilizer efficiency and long in effective period and achieves the aim of killing pests and diseases in the compound manure fertilizer during high-temperature fermentation;the contained decomposition accelerant can promote decomposition of organic fertilizers and facilitate absorption by crops; additives are excellent in heat-conducting performance to avoid root corrosion due to a large amount of heat released by unfermented manure fertilizers.

A game system including a game controller and game machine that executes a game program. The game controller including a balance platform supported at its center and under its periphery by an inflatable bladder, an air pressure source, a dual-axis accelerometer measuring tilt of the balance platform, a control valve, and an air pressure sensor measuring air pressure of the inflatable bladder. The game machine receives real time measures of the air pressure of the inflatable bladder and the tilt of the balance platform, displays on a screen a game player's location in a game space generated by the game program, based on the measures of the tilt, and changes the air pressure of the inflatable bladder during game play in response to the game program generating an interaction between the game player's location and a location of an interactive graphic image created by the game program.

The invention discloses a full-automatic degassing machine, comprising a degassing barrel (2), a slurry inlet (1), a slurry outlet (6), a stirring and crushing device (3) and a motor. The invention is characterized in that the full-automatic degassing machine also comprises an air cavity (7), an air inlet (8), an oil gas suction inlet (9), a lifting support sliding rod (21), a guide rail locatingplate (12), a double spindle lifting cylinder (24) and a brake friction plate (30), and a first ultrasonic wave probe (15), a second ultrasonic wave probe (16), a slurry blocking detection device (25) and an automatic drainer (26), and the double spindle lifting cylinder (24), a braking cylinder (28), the slurry blocking detection device (25), the motor (13), the first ultrasonic wave probe (15) and the second ultrasonic wave probe (16) are all connected with an electric control device (31). The full-automatic degassing machine disclosed by the invention has a reasonable design, a simple structure, economy and practicability, convenience in operation, good degassing efficiency, high efficiency, long service life and simplicity in mounting and dismounting.

The present invention discloses modified neurotoxins with altered biological persistence. In one embodiment, the modified neurotoxins are derived from Clostridial botulinum toxins. Such modified neurotoxins may be employed in treating various conditions, including but not limited to muscular disorders, hyperhidrosis, and pain.

The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen independent prostate cancer. The invention further relates to compositions and methods which can be used to identify and treat prostate cancer based on these novel androgen receptor splice variants, as well as methods for screening agents which modulate the activity and / or expression of the androgen receptor splice variants. Vectors, host cells and recombinant methods for producing the same and transgenic animals are also provided.

The invention discloses a goods sorting system and a sorting method. The goods sorting system comprises a feeding device, a transmitting device, a pushing device, a kick-off device and a sorting bin. The sorting bin comprises a plurality of bin bodies; the feeding device, the transmitting device, the pushing device and the kick-off device are sequentially connected; the transmitting device is a U-shaped rotation channel which comprises a feeding line and a blanking line; the feeding device is used for conveying goods onto the feeding line; the pushing device is connected with the feeding line and the blanking line, and is used for pushing goods detected on the feeding line to the blanking line; the kick-off device is used for kicking off each goods on the blanking line into one bin body; the sorting bin is located under the kick-off device; the goods sorting system further comprises a controller; and the feeding device, the pushing device and the kick-off device are controlled by the controller. The goods sorting system is compact in structure and can realize automatic sorting of goods.

A covered projectile that includes a projectile having a nose portion, a middle portion, a rear portion, and a plurality of fins extending outwardly from the rear portion, and a jacket that surrounds at least a portion of the projectile and includes an exterior surface and an interior surface. The jacket includes a front cone. A plurality of annular grooves are defined in the exterior surface of the jacket.