The invention provides a novel intelligent medicine box which has the remote management and monitoring functions and assist patients suffering from chronic diseases in taking medicine. The novel intelligent medicine box mainly comprises a central control unit (MCU), a temperature and humidity sensor, an optoelectronic switch sensor, a Bluetooth passthrough module, a WIFI module, an IIC power downstorage chip, a display screen, an early warning self-locking device, a small medicine storage cup, a high-definition camera, a real-time time module and an intelligent voice prompt module. By means of the intelligent medicine box, the patients can be reminded to take the medicine, medicine taking information and video which are recorded in the medicine taking process are sent to a doctor side, and the purpose of monitoring the patients to take the medicine in real time is achieved; meanwhile, doctor remotely controls the intelligent medicine box to achieve the medicine early warning effect.