Corticosteroids for the treatment of joint pain

a technology of corticosteroids and joint pain, which is applied in the direction of anti-inflammatory agents, drug compositions, immunological disorders, etc., can solve the problems of affecting the treatment effect of pain and/or inflammation, affecting the treatment effect, so as to reduce pain and/or inflammation, reduce the effect of long-term side effects and minimal side effects
US20120282298A1Inactive Publication Date: 2012-11-08FLEXION THERAPEUTICS
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Patent Information

Authority / Receiving Office
US Ā· United States
Current Assignee / Owner
FLEXION THERAPEUTICS
Publication Date
2012-11-08
Estimated Expiration
Not applicable Ā· inactive patent

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Abstract

Corticosteroid microparticle formulations are provided for use for treating pain, including pain caused by inflammatory diseases such as osteoarthritis or rheumatoid arthritis, and for slowing, arresting or reversing structural damage to tissues caused by an inflammatory disease, for example damage to articular and / or peri-articular tissues caused by osteoarthritis or rheumatoid arthritis. Corticosteroid microparticle formulations are administered locally as a sustained release dosage form (with or without an immediate release component) that results in efficacy accompanied by clinically insignificant or no measurable effect on endogenous cortisol production.
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Description

RELATED APPLICATIONS

[0001] This application is a continuation-in-part of U.S. patent application Ser. No. 13 / 198,168, filed Aug. 4, 2011, which claims the benefit of U.S. Provisional Application No. 61 / 370,666, filed Aug. 4, 2010. The contents of each application are hereby incorporated by reference in their entirety.FIELD OF THE INVENTION

[0002] This invention relates to the use of corticosteroids to treat pain, including pain caused by inflammatory diseases such as osteoarthritis or rheumatoid arthritis, and to slow, arrest or reverse structural damage to tissues caused by an inflammatory disease, for example damage to articular and / or peri-articular tissues caused by osteoarthritis or rheumatoid arthritis. More specifically, a corticosteroid is administered locally as a sustained release dosage form (with or without an immediate release component) that results in efficacy accompanied by clinically insignificant or no measurable effect on endogenous cortisol production.BACKGROUND OF ...

Claims

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