Honey-Based Gel Composition

a gel composition and honey technology, applied in the field of honey-based gel composition, can solve the problems of difficult application and runny, composition can be separated in the container over time, and reduce the efficacy and aesthetics of the gel,

Inactive Publication Date: 2013-02-14
COMVITA NEW ZEALAND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One of the difficulties of honey for use in wound dressing applications is that honey is a naturally sticky substance that if applied to a wound can be difficult to apply and runny.
A drawback of the composition as described in U.S. Published Application No. 2010/0233283 is that the composition when stored in the container over time can separate, particularly at temperatures over 3000.
This is undesirable as separation reduces efficac...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

working examples

[0062]The gel composition of the present application is now described with reference to examples illustrating embodiments of the composition.

example 1

[0063]A composition containing honey (manuka honey with a UMF level of 12+) (80% wt), myristyl myristate (15% wt) and caprylyl capryl glyceride (5% wt) was manufactured and added to a tube container. The tube container was then irradiated at 25 kGy following standard irradiation protocols used for medical wound dressings that contain honey.

[0064]Baseline control tests were completed and the composition appeared smooth and free of griminess having a cream like consistency, a soft fine grain and little or no glucose crystals.

[0065]The pH of the composition was 3.5-4.5 and an antibacterial activity >10% phenol equivalent or >10 UMF activity over the shelf life.

example 2

[0066]A composition containing honey (jellybush honey with a UMF level of 12+) (80% wt), myristyl myristate (15% wt) and caprylyl capryl glucoside (5% wt) was manufactured and added to a tube container. The tube container was then irradiated at 25 kGy following standard irradiation protocols used for medical wound dressings that contain honey.

[0067]Baseline control tests were completed and the composition appeared smooth and free of grittiness having a cream like consistency, a soft fine grain and little or no glucose crystals.

[0068]The pH of the composition was 3.5-4.5 and an antibacterial activity >10% phenol equivalent or >10 UMF activity over the shelf life.

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Abstract

A honey based composition is described. The composition includes a mixture of honey, a short chain fatty alcohol and a fatty ester or wax. The composition has applications for use in wound dressings and in one embodiment may be a gel. The composition has a higher than expected storage stability, remaining stable for many weeks when held at elevated temperatures and retains all of the other desirable characteristics including anti-microbial activity.

Description

RELATED APPLICATIONS[0001]This application claims priority from NZ584463 dated 7 Apr. 2010, the contents of which are incorporated herein by reference.TECHNICAL FIELD[0002]The present application relates to a gel composition. More specifically, the application relates to a storage stable and natural based composition containing honey that has a gel structure and, on application to a wound, forms a skin over the wound.BACKGROUND ART[0003]Honey used in wound dressings has been extensively discussed and taught in the art.[0004]One of the difficulties of honey for use in wound dressing applications is that honey is a naturally sticky substance that if applied to a wound can be difficult to apply and runny. Solutions have is been proposed in the art to overcome this drawback of honey and yet still maintain the honey efficacy in wound treatment.[0005]One example is the use of alginate gums mixed with the honey to form gels. Another alternative is that described in U.S. Published Applicati...

Claims

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Application Information

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IPC IPC(8): A61K35/12A61P17/02A61K35/644
CPCA61K9/0014A61K35/644A61L26/0057A61K9/06A61K31/23A61K31/7028A61P17/02
Inventor THOMPSON, FATMA BILGE
Owner COMVITA NEW ZEALAND
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