Paediatrics aminophylline insant sheet

A technology of aminophylline and aminophylline, which is applied in the direction of drug combination, medical preparation of non-active ingredients, pill delivery, etc., to achieve the effect of high bioavailability and fast onset of action

Inactive Publication Date: 2008-06-18
何德义
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in current clinical practice, there is no such oral preparation that can be personalized for drug administration,

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030] The focus of the present invention is to allow each child who needs to take aminophylline preparations to easily obtain the most suitable dosage for them through innovative specifications and styles of products, so as to achieve the purpose of safe, effective and convenient treatment. Relatively, the types and dosages of excipients under specific specifications, and even whether they are soluble tablets, effervescent tablets, or buccal tablets, are not the most important.

[0031] (1) Take 3 to 5 grams of aminophylline, feed certain auxiliary materials in an appropriate proportion, carry out wet or dry granulation in a certain way, and then press into 1000 tablets, or mix all the main ingredients and auxiliary materials The dry powder is directly mixed and pressed into 1000 tablets. The tablets made according to this plan are taken 2 times a day, 1 tablet per 1 kg of body weight each time.

[0032] (2) Take 6 to 10 grams of aminophylline, feed certain auxiliary materia...

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PUM

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Abstract

The invention relates to an aminophylline soluble tablet with special specification for children, comprising effective amount of aminophylline and water-soluble medicinal excipient which disintegrates fast in the water to release the efficacy. When the patient takes the tablets, the patient can determine the number of the tablets according to the weight of the patient, so the personalized administration can be realized, the drug intake is more accurate, and the safety is higher. After the drug is dissolved in the water, the water becomes a sweet and sour beverage, so the taken method is more acceptable by the children. At the same time, the drug solution is easy to be fully absorbed with high bioavailability.

Description

1. Technical field [0001] The invention belongs to the field of pharmaceutical preparations. Specifically, it relates to an oral preparation of aminophylline specially designed for children, specifically a soluble tablet of small aminophylline. 2. Background technology [0002] Aminophylline is an antiasthmatic drug, and its chemical name is 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione-1,2-ethylenediamine salt dihydrate. Aminophylline can directly act on bronchial smooth muscle, relieve spasm, and achieve the purpose of relieving asthma; it can also enhance myocardial contraction, dilate coronary arteries, and significantly increase cardiac output and coronary blood flow. It can be used to treat asthmatic patients with cardiac insufficiency. Theophylline is a purine receptor blocker, which can resist the constriction effect of adenine on the airway. Theophylline can enhance the contractility of the diaphragm, especially when the contraction of the diaphragm is weak, so it...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K9/20A61K47/12A61P11/00A61P11/06
Inventor 何德义
Owner 何德义
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