Compound nateglinide valsatan medicinal composition

A technology of nateglinide and composition, applied in the field of double-layer tablet and preparation thereof, can solve the problems of inability to carry out satisfactory dissolution, poor disintegration, inability to exert quick effect and the like

Inactive Publication Date: 2010-06-30
TIANJIN HANKANG PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Nateglinide is a poorly soluble drug. When capsules or tablets filled with the original drug of nateglinide are taken orally, satisfactory dissolution cannot be carried out due to poor disintegration, and as a result, the quick effect of nateglinide cannot be exerted. , the effect of lowering the blood sugar level in a short period of time, in order to bring into play the unique drug effect of nateglinide, it is necessary to make the drug release from only concentrated to realize vegetarianism, thus the present invention is proposed

Method used

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  • Compound nateglinide valsatan medicinal composition
  • Compound nateglinide valsatan medicinal composition
  • Compound nateglinide valsatan medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] prescription composition

[0053]

[0054] Preparation Process

[0055] 1) Preparation of the first layer: Weigh nateglinide, microcrystalline cellulose 301, mannitol, menthol, aspartame, croscarmellose sodium, and mix them uniformly with 95% ethanol solution to make soft material, granulate with 12-20 mesh screen, dry at 30-70°C, granulate with 12-20 mesh screen, add magnesium stearate, mix evenly, and press the first layer.

[0056] 2) To prepare the second layer of granules, weigh valsartan, lactose, sodium carboxymethyl starch, and sodium lauryl sulfate, and mix them uniformly by adding in equal amounts, then use 50% ethanol solution to make a soft material, 12- Granulate with a 20-mesh screen, dry at 30-70°C, granulate with a 12-20-mesh screen, add magnesium stearate, mix evenly, and press the second layer.

[0057] 3) Tablet compression: After adjusting the weights of the two layers, press them into double-layer tablets with a multifunctional tablet press.

Embodiment 2

[0058] Embodiment 2 (prior art)

[0059] prescription composition

[0060] Naglinide

30mg / tablet

Microcrystalline Cellulose 301

40mg / tablet

Mannitol

40mg / tablet

Croscarmellose Sodium

8mg / tablet

Menthol

0.5mg / tablet

[0061] Naglinide

30mg / tablet

aspartame

0.5mg / tablet

Valsartan

80mg / tablet

lactose

30mg / tablet

Carboxymethyl Starch Sodium

8mg / tablet

Sodium dodecyl sulfate

0.5mg / tablet

Magnesium stearate

2.5mg / tablet

[0062] Preparation Process

[0063] Weigh nateglinide, microcrystalline cellulose 301, mannitol, menthol, aspartame, croscarmellose sodium, valsartan, lactose, carboxymethyl starch sodium, lauryl sulfate Sodium, mix evenly by adding equal amount, make soft material with 75% ethanol solution, granulate with 12-20 mesh screen, dry at 30-70°C, granulate with 12-20 mesh screen, add magnesium stearate, Mix evenly, press...

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Abstract

The invention relates to a compound nateglinide valsatan medicinal composition, which is a dual-layer tablet and comprises a first layer of nateglinide and a second layer of valsatan, wherein the first layer is delivered from a self-soluble tablet to be immediately released; and the second layer is released from a self-disintegration or corroded tablet matrix.

Description

technical field [0001] The invention relates to a compound nateglinide valsartan pharmaceutical composition, a double-layer tablet and a preparation method thereof. Background technique [0002] Nateglinide, Nateglinide, chemical name: N-(trans-4-isopropylcyclohexyl-1-formyl)-D-phenylalanine, this product is a derivative of D-phenylalanine, It belongs to non-sulfonylurea hypoglycemic drugs, and its mechanism of action is mainly to block the opening of ATP-sensitive potassium channels in islet cells by binding to sulfonylurea receptors on islet B cells, resulting in depolarization of the cell membrane and opening of calcium channels. Promote insulin secretion. This product is a new type of mealtime blood sugar regulator, which can effectively control the postprandial blood sugar level. It has the characteristics of fast onset, short action time, low incidence of cardiovascular side effects and hypoglycemia. Oral absorption of this product is rapid. Healthy volunteers take 2...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/41A61K31/198A61K9/24A61P3/10A61P9/12
Inventor 严洁黄欣
Owner TIANJIN HANKANG PHARMA BIOTECH
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