Colon target-positioning preparation for treating colonitis and preparing method

A colon-targeting and colitis technology, which is applied to non-active ingredients in medical preparations, pharmaceutical formulations, aluminum/calcium/magnesium active ingredients, etc. problem, to achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2007-11-14
刘庆芸
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, enema administration is very painful for patients, and the workload of medical staff is heavy, and it is inconvenient to use, so patients' compliance is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of montmorillonite colon-positioned enteric-coated tablets

[0030] Montmorillonite tablet core prescription:

[0031] Montmorillonite: 500.0g

[0032] Starch: 10.0g

[0033] Magnesium stearate: 2.5g

[0034] Montmorillonite tablet coating prescription:

[0035] Acrylic Endrgits-100: 50.0g

[0036] Diethyl phthalate: 2.4g

[0037] 95% ethanol: 1000ml

[0038] The montmorillonite is weighed and mixed uniformly with various auxiliary materials, and the soft material is prepared with a wetting agent (the ratio of 95% ethanol to water (v / v) 1:0.2), granulated, dried and sized. Magnesium stearate is added, compressed into tablets, and coated under the above conditions, and the weight of the coating increases by 3-6%.

Embodiment 2

[0040] Preparation of montmorillonite colon-localized enteric-coated tablets

[0041] Montmorillonite tablet core prescription:

[0042] Montmorillonite: 500.0g

[0043] Sodium carboxymethyl starch: 5.0g

[0044] Magnesium stearate: 2.5g

[0045] Montmorillonite tablet coating liquid prescription:

[0046] Acrylic Endrgits-100: 50.0g

[0047] Diethyl phthalate: 2.4g

[0048] 95% ethanol: 1000ml

[0049] Coating parameters:

[0050] Flow rate of coating solution: 2.6ml / min

[0051] Inlet temperature: 40℃

[0052] Spray pressure: 1.3kgf / cm 2

[0053] The montmorillonite is weighed and mixed uniformly with various auxiliary materials, and the soft material is prepared with a wetting agent (the ratio of 95% ethanol to water (v / v) 1:0.2), granulated, dried and sized. Magnesium stearate is added, compressed into tablets, and coated under the above conditions, and the weight of the coating increases by 3-6%.

Embodiment 3

[0055] Preparation of montmorillonite colon-localized enteric-coated tablets

[0056] Montmorillonite tablet core prescription:

[0057] Montmorillonite: 500.0g

[0058] Syrup: 15.0g

[0059] Magnesium stearate: 3g

[0060] Montmorillonite tablet coating liquid prescription:

[0061] Acrylic Endrgits-100 50.0g

[0062] Diethyl phthalate 2.4g

[0063] 95% ethanol 1000ml

[0064] Coating parameters:

[0065] Coating flow rate: 2.6ml / min

[0066] Inlet temperature: 40℃

[0067] Spray pressure: 1.3kgf / cm2

[0068]The montmorillonite is weighed and mixed uniformly with various auxiliary materials, and the soft material is prepared with a wetting agent (the ratio of 95% ethanol to water (v / v) 1:0.2), granulated, dried and sized. Magnesium stearate is added, compressed into tablets, and coated under the above conditions, and the weight of the coating increases by 3-6%.

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PUM

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Abstract

The present invention provides a kind of colon target orientation preparation for curing colitis and its preparation method. Said preparation is formed from 250-500g of montmorillonite, 3-15g of binding agent and 0.20-3.0g of lubricating agent. Said colon target orientation preparation can be made into oral enteric soluble tablet or oral enteric soluble capsule. Besides, said invention also provides the concrete steps of its preparation method.

Description

(1) Technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a colon-targeted and localized preparation for treating colitis and a preparation method thereof. (2) Technical background [0002] Montmorillonite medicine has a network structure and non-uniform charge distribution. It has a fixed inhibitory effect on digestive tract viruses, bacteria and the toxins they produce, and has a fixed covering ability on the digestive tract mucous membrane. At present, it is widely used clinically, and it can selectively bind to mucosal fluid proteins and cover the mucosal surface. Prevent viruses, germs, and toxins from eroding. It also locally stops bleeding in the digestive tract by activating coagulation factors VI, VII, and XII. By strengthening the barrier function of the digestive tract mucosa, it helps the regeneration and repair of the epithelial tissue of the digestive tract as well as fixes and absorbs it, so that the inflammation of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/06A61K47/36A61K47/12A61K47/32A61P1/00
Inventor 刘庆芸
Owner 刘庆芸
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