Vortioxetine freeze-dried orally disintegrating tablet and preparation method thereof

Abstract

The invention discloses a vortioxetine freeze-dried orally disintegrating tablet and a preparation method thereof. The vortioxetine freeze-dried orally disintegrating tablet with the vortioxetine as an active pharmaceutical ingredient comprises, by weight, 2%-75% of vortioxetine, 10%-85% of a skeleton supporting agent, 2%-55% of binder, 0.5%-55% of a suspending agent, 0.5%-30% of antioxidant, 0.2%-10% of corrigent, a defined amount of pH regulator and a defined amount of injection water. The vortioxetine freeze-dried orally disintegrating tablet is prepared through a freeze-drying device and has the advantages of being high in disintegrating speed, high in dissolution rate, good in stability and convenient to take and carry, and the compliance of a patient to take medicine is greatly improved.

Description

technical field

[0001] The invention relates to a pharmaceutical preparation in the field of oral rapid release, in particular to a freeze-dried orally disintegrating tablet of vortioxetine and a preparation method thereof. Background technique

[0002] In today's society, with the increasingly tense pace of life, the number of patients with depression is astonishing. The pathogenesis of depression is mainly due to the low content of central norepinephrine (NE), 5-hydroxytryptamine (5-HT) and dopamine (DA) in the body and the decline of their receptor function. The functions of monoamine neurotransmitters in the brain are relatively complex, among which 5-HT seems to play a basic role in controlling sensory responses, NE is mainly related to insomnia and inattention, and DA controls more running and cognitive functions. These neurotransmitters have complex interactions, and together affect the human body's psychological behaviors such as anxiety and tension.

[0003] Vorti...

Images