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95results about How to "Reduce the use volume" patented technology

Method for preparing vesicle medicinal nanoparticles

The invention relates to the technical field of medicines, and relates to design, preparation and application of vesicle nanoparticles of insoluble medicines. The invention comprises the following aspects: (1) a model medicine is dissolved in a good solvent to form a medicinal solution, and a functional stabilizer is dissolved in another solvent to form a poor medicinal solution; and (2) the medicinal solution is mixed with the poor solvent, and vesicle nanocrystal suspension of which the average effective particle size of less than 1 mu m is formed through self-assembly. A micromolecular material with high compatibility is selected, and a macromolecular polymer stabilizer is synthesized by a covalent binding technology; by microsedimentation, self-assembly and surface modification technologies, the medicine is stabilized in the poor solvent in a form of pure nanocrystals, and a problem that the insoluble medicines are hardly prepared into solution preparations and the problems of dumping and passivity of the traditional nanoparticles are solved; and compared with the traditional preparations, the vesicle nanoparticles have the advantages that the adverse reaction is reduced, toxic and side effects are reduced, the bioavailability is improved, and the vesicle nanoparticles have controlled-release and active targeting functions, and are convenient to use.
Owner:NANJING LAKESEN BIOPHARM TECH CO LTD

Fat SVF cell clinical high-efficiency preparation and cryopreservation method, and applications thereof

The invention discloses a fat SVF cell clinical high-efficiency preparation and cryopreservation method, and applications thereof. The fat SVF cell clinical high-efficiency preparation and cryopreservation method comprises following steps: S1, fat samples are collected under aseptic conditions, and are preserved in a preserving fluid, and a washing liquid is added for pre-treatment of the fat samples; S2, after pre-treatment, the fat samples are subjected to centrifugalization so as to obtain yellow fat tissue, the fat tissue is added into a preheated digestive juice, an obtained mixture is sealed, under constant temperature conditions, the fat tissue and the digestive juice are mixed to be uniform, digestion is carried out until no large tissue block is left or even large tissue blocks are left, a large amount of fat is gathered, and then centrifugation is carried out, wherein the volume ratio of the fat tissue to the preheated digestive juice is controlled to be 1:1; and S3, after centrifugation, upper layer fat is removed, the washing liquid is added for resuspending and uniform mixing of an obtained residue, filtering is carried out, the washing liquid is added again, centrifugation is carried out, and an obtained supernatant is removed so as to obtain fat SVF cells. According to the fat SVF cell clinical high-efficiency preparation and cryopreservation method, the washing liquid and the digestive juice are used for increase the cell number, the cell living rate, and the purity of the obtained fat SVF cells, and the effect of the extracted SVF cells in clinical treatment is ensured.
Owner:SHANGHAI LIFE SCI & TECH CO LTD

Functional assembly, mobile terminal and control method thereof

The invention discloses a functional assembly. The functional assembly includes a sliding seat, a base and a driving assembly; a camera module is arranged on the sliding seat; Containing cavity is formed in the base, the sliding seat slidably stretches into the accommodating cavity; the driving assembly is accommodated in the accommodating cavity; The driving assembly comprises a motor, a rotatingshaft, a first traction member and a second traction member; the first traction piece comprises a first end part and a second end part which are opposite to each other; the second traction piece comprises a third end part and a fourth end part which are opposite to each other; The first end and the third end are wound on the rotating shaft and are opposite in winding direction, the second end andthe fourth end are connected to the sliding base and are opposite in traction direction, and when the motor drives the rotating shaft to rotate, the first traction piece or the second traction piecepulls the sliding base so that the sliding base can carry the camera module to extend out of or retract into the containing cavity. The camera module can stretch out and draw back relative to the baseand is convenient to carry by a user, the use size is reduced, and user experience is improved. The invention further discloses a mobile terminal and a control method thereof.
Owner:GUANGDONG OPPO MOBILE TELECOMM CORP LTD

Planetary soil transfer and dust-proof seal device

The invention discloses a planetary soil transfer and dust-proof seal device. The device comprises a substrate, a soil transfer mechanism and a dust-proof seal mechanism, wherein the planetary soil transfer mechanism comprises a guide rail arranged between two sliding brackets; a stroke motor is arranged on the substrate which can slide reciprocally along the guide rail; a first gear which is engaged with a rack is arranged on the rotating shaft of the stroke motor; a turning plate is arranged in a hopper; the rotating shaft of the turning plate is provided with a second gear which is engaged with a triggering rack; the dust-proof seal mechanism comprises a first motor seat, a pressure spring, a motor and a rotating cover, wherein a voice coil linear motor is arranged in the first motor seat; the pressure spring is positioned at the bottom of the voice coil linear motor; the motor is connected with the rotating shaft; the rotating cover is arranged on the rotating shaft and is in clearance fit with the rotating shaft; one end of the rotating cover is provided with an opening for planetary soil to pass; the other end is a seal cover; a force transmission rod is arranged on the seal cover; and a seal cup is arranged on a cup seat which is arranged below the rotating cover. The device has the characteristics of small volume, light weight, low power consumption, less required motors, dust prevention and sealing.
Owner:江苏明江阀业有限公司 +1

Method for separating and preparing exosome

InactiveCN109266613AImproved separation and preparation methodsHigh purityCell dissociation methodsTumor/cancer cellsCellular DebrisCentrifugation
The invention relates to a method for separating and preparing exosomes, belonging to the field of biotechnology. The method for separating and preparing exosome comprise that following steps: 1) removing cellular impurities by centrifugation; 2) centrifuging to remove cellular debris and large protein impurities; 3) transferring that supernatant into a new centrifugal tube, centrifuging to discard the precipitate and leave the supernatant; 4) filtering that supernatant and transferring; 5) mixing that reagent XBP and the sample, transferring the reagent XBP into a membrane adsorption column,centrifuging, and discarding the liquid at the bottom of the tube; 6) centrifuging to remove liquid remaining on that membrane; 7) adding reagent XWP, centrifuging, discarding that liquid at the bottom of the tube, and changing the column into a new centrifugal tube; and 8) adding that reagent XE to the column, centrifuging and eluting the exocrine body to obtain the liquid containing the exocrinebody. The RNA purity of the extracted exocrine body is improved, the impurity is less, the biological sample volume of the initially extracted exocrine body can be reduced, and the yield of the circulating exocrine body can be improved.
Owner:INST OF HEMATOLOGY & BLOOD DISEASES HOSPITAL CHINESE ACADEMY OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE

Rapamycin slow-release dosage form as well as preparation method, rapamycin slow-release injection and application

The invention provides a rapamycin slow-release dosage form as well as a preparation method, a rapamycin slow-release injection and application, which relate to the technical field of medicines. The rapamycin slow-release dosage form comprises rapamycin and a slow-release material in a mass ratio of 1: (10 to 50). The rapamycin slow-release dosage form is high in drug content, capable of realizinga slow-release and controlled-release effect of a drug, and capable of effectively alleviating and treating osteoarthritis. The preparation method of the rapamycin slow-release dosage form provided by the invention is simple to operate, and the prepared rapamycin slow-release dosage form is good in stability, long in retention time in a human body, high in bioavailability, and favorable for the popularization and application of industrialized production. The rapamycin slow-release injection can be directly injected without using an organic solvent, can reduce the adverse reaction and safety accidents caused by the organic solvent, is long in retention time in the human body, does not need to be repeatedly injected for multiple times, can reduce the cost of administrating the drug for multiple times, and can alleviate the pain of a patient and the irritation.
Owner:白晓春

Underwater acoustic array output cable and sealed connection method thereof

The invention relates to an underwater acoustic array output cable comprising multi-stage cable unit. Each two adjacent stages of cable units are connected mutually by a sealed connection structure. The sealed connection structure consists of an adapter and a switch sleeve. Wire tapping units of the cable unit at the previous stage and the cable unit at the later stage are connected to and installed at the adapter and are in contact at the adapter to form electrical connection. Each switch sleeve being vulcanized rubber sleeve is arranged at the periphery of the cable unit at the previous stage, the cable unit at the later stage, and the adapter and covers the exposed wire tapping unit of the cable unit at the previous stage, the exposed wire tapping unit of the cable unit at the later stage, and the adapter completely. According to the invention, each vulcanized rubber sleeve coats the connection part between each two adjacent stages of cable units to realize comprehensive sealing of the connection part between the cable unit at the previous stage and the cable unit at the later stage. The structure of the cable is simple; and the insulating property of underwater sealing of the underwater acoustic array output cable is enhanced.
Owner:HAIYING ENTERPRISE GROUP

Transferring and dustproof sealing device for planet soil

The invention provides a transferring and dustproof sealing device for planet soil. The device is composed of a base plate, a soil transferring mechanism and a dustproof sealing mechanism. The soil transferring mechanism includes a guide rail disposed between two sliding supports, a sliding base plate which can move back and forth along the guide rail, a lead screw with one end being connected to a stroke motor while the other end going through the sliding base plate, and a funnel which is provided with an inner turnover panel and can move back and forth along with the sliding base plate. The dustproof sealing mechanism includes a second motor base fixedly equipped with a pressure motor and a slide bar, a forcing bar with both ends being connected to the slide bar in a sliding manner, a third motor base equipped with a pressure motor connecting with a rotary shaft, a rotary cover which is installed on the rotary shaft and is in clearance fit with the rotary shaft, a sealing cup and a cup holder disposed under a dust ring, wherein one end of the rotary cover is provided with an opening for the passage of soil while the other end of the rotary cover is a sealing cover provided with a dowel bar. The device with the transferring mechanism and the rotary sealing mechanism in the invention has the characteristics of small size, low weight, low power consumption, low demand on motor number and dustproof sealing.
Owner:JIANGSU SHUANGSHUANG TECH CO LTD +1

Drawing device for middle school mathematical education

The invention discloses a drawing device for middle school mathematical education. The drawing device comprises a drawing plate; a step edge is arranged on the back side of the drawing plate; an angular adjusting rod is mounted at the left end of the step edge; a conical coiling drum is mounted inside the bottom of the step edge; a spring is mounted at the right end of the conical coiling drum; aprotractor winds around the surface of the conical coiling drum; the other side of the protractor is fixedly connected onto the angular adjusting rod; a straight line groove is formed in the middle ofthe top surface of the drawing plate and longitudinally penetrates through the drawing plate; a first pen clamp is mounted in the straight line groove and comprises a fastening button; the fasteningbutton is mounted at the top of the straight line groove; a threaded column is in screw connection with the middle of the fastening button; the bottom of the threaded column is connected with a circular-truncated-cone-shaped pen sleeve; the outer ring of the bottom of the pen sleeve is in screw connection with a circular-truncated-cone-shaped limiting piece; a graduated scale is arranged at the front end of the straight line groove; a point adjusting device is arranged at the left end of the straight line groove; an angular rail nail is mounted at the bottom of the point adjusting device; a telescopic pipe with the square section is arranged at the front end of the point adjusting device; and a second pen clamp is arranged at the tail end of the telescopic pipe.
Owner:杨平

Building sewage treatment device and method

The invention discloses a building sewage treatment device and method. The device comprises a box body, a cylinder body, a lifting plate, an electric telescopic rod, a circular ring, a flow guide plate, a water outlet pipe, a bottom sealing plate, a second supporting plate, a third supporting plate and a controller, wherein multiple groups of supporting rods are arranged on the inner wall of the box body; a sludge box is arranged at the inner side of the bottom of the box body; the outer wall of the cylinder body is rotationally connected with the end parts of the multiple groups of supportingrods; the electric telescopic rod is arranged at the inner side of the top of the box body; the lifting plate is arranged at the bottom of the electric telescopic rod; the circular ring is horizontally arranged on the outer wall of the cylinder body; the flow guide plate is arranged on the inner wall of the box body; the water outlet pipe is arranged on the flow guide plate; the bottom sealing plate is a metal plate; the second supporting plate is arranged on the outer wall of the bottom of the cylinder body; a permanent magnet is arranged at the bottom of the second supporting plate; a second rotating mechanism is arranged on the inner wall of the box body; an electromagnet is arranged on a sliding block; and the controller is arranged on the outer side of the top of the box body. According to the device, water can be quickly separated from solid substances such as silt and concrete, and the solid substances such as the silt and the concrete in the cylinder body fall into the sludgebox in time.
Owner:刘雪莲

Preparation method and use of poultry vaccine-specific pig spleen transfer factor

The present invention discloses a preparation method for a poultry vaccine-specific pig spleen transfer factor. The preparation method comprises: selecting poultry vaccine antibody-positive pigs, and slaughtering to obtain pig spleen; carrying out cold preservation; thawing the pig spleen; removing fascia; mincing; homogenizing; filling into a bottle, and storing; carrying out repeated freezing and thawing; carrying out centrifugation; carrying out microfiltration; carrying out ultra-filtration; inactivating; adjusting the pH value; adjusting an osmotic pressure; sterilizing; and testing quality. According to the present invention, in the homogenizing step, the pH value of water for injection is adjusted to 4-6 so as to easily increase yields of ribose and polypeptides; the box type member package tangential flow filtration is adopted, such that the residual dead volume of the system is small, and linear enlargement production is easily achieved; the transfer factor crude product is subjected to tangential flow nano-filtration through a 1-3 KD box type member package to prepare the high concentration transfer factor so as to increase a use effect; phenol red is adopted as a pH value indicator, such that customers easily observe the pH value of the transfer factor; and beta-propiolactone is adopted to replace the traditional formaldehyde to inactivate the transfer factor, and the osmotic pressure adjustment process is added so as to easily achieve transfer factor and vaccine combined immunization.
Owner:派生特(福州)生物科技有限公司 +1

Method for conveniently and quickly purifying dihydromyricetin from ampelopsis grossedentata leaves

The invention discloses a method for conveniently and quickly purifying dihydromyricetin from ampelopsis grossedentata leaves. The method comprises the following steps: a, crushing ampelopsis grossedentata leaves, extracting the crushed ampelopsis grossedentata leaves by using alcohol/water with the volume fraction of 70-90%, and separating in a centrifuging or filtering manner to obtain an alcohol extracting solution, wherein the used alcohol is ethanol, methanol or isopropanol; b, adding water into the alcohol extracting solution, removing the alcohol solvent in the alcohol extracting solution through reduced pressure distillation under the water bath condition of 40-50 DEG C, gradually separating out solids from the remaining water-based solvent along with the gradual distillation removal of alcohol from the solvent, standing for cooling to room temperature, and then centrifuging or filtering to remove water to obtain a primarily extracted solid; and c, washing the primarily extracted solid with water, then carrying out suspension washing with an alcohol-containing ethyl acetate, alcohol-containing dichloromethane or alcohol-containing chloroform mixed solution, filtering to remove the washing solution, and drying to obtain dihydromyricetin, wherein the used alcohol is ethanol, methanol or isopropanol. The method has the advantages of simple operation, high extraction yieldand the like.
Owner:SOUTH CHINA AGRI UNIV +1

Two-phase-flow well injection and brine extraction technology for alkali mixed liquor prepared through ammonia-alkali process

The invention relates to the technical field of recycling of alkali mixed liquor prepared through an ammonia-alkali process, in particular to a two-phase-flow well injection and brine extraction technology for an alkali mixed liquor prepared through an ammonia-alkali process. The technical scheme includes that the technology includes firstly, subjecting the alkali mixed liquor prepared through theammonia-alkali process to sand separation, decreasing the temperature of the obtained alkali mixed liquor to 50 DEG C after cogeneration and flash cooling, delivering the obtained alkali mixed liquorfrom an alkali factory area to a storage bucket with a stirring device in a salt mine area for storage through a slurry pump and a steel-skeleton plastic composite pipe, delivering the obtained alkali mixed liquor to a Glauber's salt type salt mine well when the stirring device in the storage bucket is in operation, and carrying out sulfate ion and calcium ion reaction as well as natural settlingso as to obtain brine. The two-phase-flow well injection and brine extraction technology for the alkali mixed liquor prepared through the ammonia-alkali process is low in pollution and cost, therebycreating higher economic and environmental benefits.
Owner:JIANGXI JINGHAO SALINIZATION

Functional assembly, electronic device and control method thereof

The invention discloses a functional assembly. The functional assembly comprises a base, a sliding seat and a driving assembly, wherein the sliding seat is telescopically connected to the base in a sliding mode, a camera module is arranged on the sliding seat, the driving assembly is arranged in the base and comprises an elastic piece, a cam and a driving piece used for driving the cam to rotate,one end of the elastic piece is fixed relative to the base, the other end of the elastic piece is connected with the sliding seat, and the cam is provided with a rotating center, a far end point and anear end point. When the driving piece drives the cam to rotate, the contact position of the cam and the sliding seat moves from the near end point to the far end point to push the sliding seat, so that the camera module extends out of the base, and the elastic piece is stretched; and when the driving part is stopped, the elastic part returns to pull the sliding seat close, so that the camera module retracts into the base, and the cam is pushed back to the original position. The camera module can stretch out and draw back relative to the base and is convenient to carry by a user, the use sizeis reduced, and the user experience is improved. The invention further discloses an electronic device and a control method thereof.
Owner:GUANGDONG OPPO MOBILE TELECOMM CORP LTD

Method for preparing vesicle medicinal nanoparticles

The invention relates to the technical field of medicines, and relates to design, preparation and application of vesicle nanoparticles of insoluble medicines. The invention comprises the following aspects: (1) a model medicine is dissolved in a good solvent to form a medicinal solution, and a functional stabilizer is dissolved in another solvent to form a poor medicinal solution; and (2) the medicinal solution is mixed with the poor solvent, and vesicle nanocrystal suspension of which the average effective particle size of less than 1 mu m is formed through self-assembly. A micromolecular material with high compatibility is selected, and a macromolecular polymer stabilizer is synthesized by a covalent binding technology; by microsedimentation, self-assembly and surface modification technologies, the medicine is stabilized in the poor solvent in a form of pure nanocrystals, and a problem that the insoluble medicines are hardly prepared into solution preparations and the problems of dumping and passivity of the traditional nanoparticles are solved; and compared with the traditional preparations, the vesicle nanoparticles have the advantages that the adverse reaction is reduced, toxic and side effects are reduced, the bioavailability is improved, and the vesicle nanoparticles have controlled-release and active targeting functions, and are convenient to use.
Owner:NANJING LAKESEN BIOPHARM TECH CO LTD
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