The invention relates to a high-effective desulfuration dedusting purification system of coal boiler flue gas, in particular to a purification equipment of industrial waste gas. The invention provides the highly effective desulfuration dedusting purification system with good desulfuration dedusting effect. The system is provided with a deduster, a draft fan, a booster fan, an absorption tower, a process water pump, a process water tank, an oxidation air blower, a hydraulic cyclone, a slurry pump, a stirrer, a recycle pump, a slurry transfer pump, a clarified water pump, a clarified water tank, a dispensing pump, a concentration groove, a water-ring vacuum pump, a belt filter press, a gas-water separator, a filtration fabric flushing pump, a filtration fabric flushing water tank, a filtrate water pump, a filtrate neutralization box, An electric butterfly valve, an electromagnetic valve, an intercepting valve, a regulating valve, a check valve, etc. The coal boiler flue gas is desulfurized and dedusted through dedusting before desulfuration, lime-spraying desulfuration, liquid absorption, air blowing oxidation, defogging purification, neutral liquid circulation, cyclone separated lime latex, gas water separation, mechanical filtration, etc., thus reaching the emission standard; the water and lye can be recycled, the invention has low cost for operating the system and no secondary pollution.