The invention relates to a retinervus luffae fructus meridian promoting and collateral activating wine and a preparation method thereof, wherein the raw materials comprise, by weight, 25-35 parts of retinervus luffae fructus, 15-20 parts of typha angustifolia l, 15-20 parts of abutilon indicum(l.)sweet, 5-10 parts of gnaphalium affine d. don, 5-10 parts of the fruit of cinnamomum camphora (l.) presl, 5-10 parts of viola japonica, 5-10 parts of wallich pepper stem and leaf, 3-5 parts of portulaca oleracea l, 3-5 parts of thlaspi arvense linn, 3-5 parts of trapa incisa var. sieb, 3-5 parts of bidens pilosa l, 3-5 parts of fructus broussonetiae, 300-400 parts of grain wine, and 400-500 parts of yellow wine. The main steps of the preparation method comprise: 1, preparing traditional Chinese medicine fine powder; 2, preparing a medicine wine; and 3, mixing. According to the present invention, the Chinese herbs, the yellow wine and the grain wine are reasonably and effectively combined, such that the retinervus luffae fructus meridian promoting and collateral activating wine provides effects of meridian promoting, collateral activating, detoxification, and swelling subsiding for trauma bleeding, amenorrhea, dysmenorrhea and other main diseases to different degrees.