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Method for extracting isofraxidin from acanthopanax roots

A technology of isoazine pyridoxine and Acanthopanax senticosus, applied in the direction of organic chemistry and the like, can solve the problems of large recovery load of organic solvents, inability to reuse, loss, etc., and achieve the effect of reducing production costs and facilitating industrial-scale production.

Active Publication Date: 2018-09-04
NORTHEAST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This type of method has the following defects: in addition to the presence of free isozinidine in Acanthopanax, there is also bound isozinidine; if the bound isozinidine is not extracted, the loss of about 30% isozinidine will be caused At the same time, the organic solvent used for resin or silica gel separation has a large recovery load and cannot be reused, resulting in waste of cost and energy

Method used

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  • Method for extracting isofraxidin from acanthopanax roots
  • Method for extracting isofraxidin from acanthopanax roots
  • Method for extracting isofraxidin from acanthopanax roots

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] The roots of Acanthopanax senticosus after natural air-drying are pulverized to obtain Acanthopanax senticosus powder with a particle size of 70 meshes, and 10.0 g of Acanthopanax senticosus powder (in terms of absolute dry mass) is weighed and put into a round-bottomed flask, and then pressed The mass ratio of powder and ethanol aqueous solution is 1:12, add ethanol aqueous solution with a volume percentage of 80%, reflux extraction in a water bath at 85°C for 2 hours, continue to repeat the extraction twice, combine the extracted materials, filter, The obtained liquid material is used as an extract;

[0067] to H + Type ion exchange resin (model is 001*7) carries out pretreatment, specifically adopts ethanol to H + Type ion exchange resin was soaked for 12h, and the obtained H + The type ion exchange resin is washed with distilled water; the obtained H + Type ion exchange resin was soaked for 12h, and the obtained H + The type ion exchange resin is washed with dis...

Embodiment 2

[0074] The roots of Acanthopanax senticosus after natural air-drying are pulverized to obtain Acanthopanax acanthopanica powder with a particle size of 60 meshes. Weigh 100.0g of Acanthopanax senticosus powder (in terms of absolute dry mass) and put it into a round bottom flask, then press Acanthopanax acanthopanica The mass ratio of powder and ethanol aqueous solution is 1:15, add ethanol aqueous solution with a volume percentage of 85%, reflux extraction in a 75°C water bath for 2.5 hours, continue to repeat the extraction twice, combine the extracted materials, and filter , using the obtained liquid material as an extract;

[0075] to H + Type ion exchange resin (model is 001*7) carries out pretreatment, specifically adopts ethanol to H + Type ion exchange resin was soaked for 12h, and the obtained H + The type ion exchange resin is washed with distilled water; the obtained H + Type ion exchange resin was soaked for 12h, and the obtained H + The type ion exchange resin ...

Embodiment 3

[0083] The roots of Acanthopanax senticosus after natural air-drying were crushed to obtain Acanthopanax acanthopanica powder with a particle size of 70 meshes. Weighed 1000.0g of Acanthopanax senticosus powder (in terms of absolute dry mass) and put it into a pilot-scale round-bottomed flask, and then pressed The mass ratio of Acanthopanax senticosus powder and ethanol aqueous solution is 1:10, add ethanol aqueous solution with a volume percentage of 85%, reflux extraction in a 90°C water bath for 2.5h, continue to repeat the extraction twice, and combine the extracted materials , filter, and use the obtained liquid material as an extract;

[0084] to H + Type ion exchange resin (model is 001*7) carries out pretreatment, specifically adopts ethanol to H + Type ion exchange resin was soaked for 12h, and the obtained H + The type ion exchange resin is washed with distilled water; the obtained H + Type ion exchange resin was soaked for 12h, and the obtained H + The type ion ...

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Abstract

The invention provides a method for extracting isofraxidin from acanthopanax roots. According to the method disclosed by the invention, by virtue of extraction in combination hydrolysis in situ, glycosides prepared by binding isofraxidin and glucose, namely binding state isofraxidin, can be totally transformed into free state isofraxidin, so that the content of the isofraxidin in the extracting solution is increased, wherein an H<+> type ion exchange resin serves as a catalyst for promoting hydrolysis of the binding state isofraxidin, and a chlorinated solvent serves as an extraction agent forextracting the free state isofraxidin. Therefore, in the process of extraction in combination hydrolysis in situ, hydrolysis of the binding state isofraxidin and extraction of the free state isofraxidin are simultaneously completed. Moreover, the in-situ hydrolysis extraction method provided by the invention effectively avoids onerous two-step operations of hydrolysis and extraction, the operating procedures and the usage amount of the solvent are reduced, the production cost is low, and the yield of the isofraxidin is high.

Description

technical field [0001] The invention relates to the technical field of compound extraction, in particular to a method for extracting isoxapidine from Acanthopanax. Background technique [0002] Acanthopanax is widely distributed in many provinces and regions in my country, and is one of the important Chinese herbal medicines in my country. Acanthopanax has the effects of invigorating Qi, invigorating the spleen, nourishing the kidney and calming the nerves, and can enhance the body's non-specific defense capabilities. In addition to immune regulation, anti-tumor, anti-aging, anti-radiation damage and anti-fatigue, it can also treat cardiovascular diseases, Diabetes and neurasthenia. The roots and stems of Acanthopanax senticosus contain a variety of active chemical components, among which isoxazinidine and phenolic glycosides are particularly prominent. Isoxapyridine is one of the important active ingredients in Acanthopanax, which has various pharmacological activities su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/16
CPCC07D311/16
Inventor 马春慧刘守新李伟李俊含夏宇王梦茹罗沙
Owner NORTHEAST FORESTRY UNIVERSITY
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