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Isofraxidin crystalline compound and glabrous sarcandra herb dispersible tablets and dropping pills containing isofraxidin crystalline compound

A technique for isopicrin and compound, which is applied in the field of isopicrimidine crystalline compound and the dispersible tablets and dripping pills containing the compound, and can solve the problem of high cost of membrane separation method, low isopicrimidine content, unsatisfactory effect, etc. problems, to achieve the effect of ensuring drug safety, accurate dosage and low cost

Active Publication Date: 2012-08-15
ZHEJIANG WECOME MEDICINE IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The solvent extraction method requires the use of a large amount of organic solvents, which has high cost, poor safety, and a long extraction cycle; the membrane separation method is costly and the effect is not ideal, and the content of isoferidin is still very low, and it is easy to block the membrane pores and cause membrane regeneration. difficulty

Method used

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  • Isofraxidin crystalline compound and glabrous sarcandra herb dispersible tablets and dropping pills containing isofraxidin crystalline compound
  • Isofraxidin crystalline compound and glabrous sarcandra herb dispersible tablets and dropping pills containing isofraxidin crystalline compound
  • Isofraxidin crystalline compound and glabrous sarcandra herb dispersible tablets and dropping pills containing isofraxidin crystalline compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] [Example 1] Preparation of Isoferidin crystalline compound

[0053] 1) Take 2344g of sarcophagus, chop it up, decoct three times, add 12 times the amount of water to decoct for 1 hour each time, combine the decoction, filter, and concentrate the filtrate to extract A with a relative density of 1.05-1.10 at 60°C ;

[0054] 2) Dissolve the extract in hot water, filter through a microporous membrane, apply a macroporous adsorption resin on the obtained solution, the ratio of diameter to height of the macroporous adsorption resin column is 1:10, first elute with water at a flow rate of 3V / h, and then Elute with 40% ethanol solution of 5 times the volume of the column bed at a flow rate of 3 V / h, collect the 40% ethanol eluting solution, recover ethanol, and obtain extract B;

[0055] 3) Dissolve extract B in hot water, put the obtained solution on a 200-mesh silica gel column, and elute with n-hexane and ethyl acetate with a volume ratio of 10:1 for 100 min in sequence, an...

Embodiment 2-9

[0062]

[0063] The X-ray powder diffraction spectrum obtained by measuring the isoferidin crystalline compound obtained in Examples 2-9 using Cu-Kα rays is similar to that in Example 1.

preparation Embodiment 1

[0065] [Preparation Example 1] Preparation of Zhongjiefeng Dispersible Tablets

[0066] Composition of raw materials: 2344g of sargassum, 70g of croscarmellose sodium, 70g of low-substituted hydroxypropyl cellulose, 8g of silicon dioxide, 75g of microcrystalline cellulose and 2.8g of magnesium stearate.

[0067] Preparation method: mix the yellow crystalline powder prepared in step 4) of Example 1 with the solid obtained in step 3) of Example 1 to obtain the Sargassum extract; Mix with 50g croscarmellose sodium, 70g low-substituted hydroxypropyl cellulose, 7.2g silicon dioxide and 75g microcrystalline cellulose, granulate, dry, then add 20g croscarmellose sodium , 0.8g silicon dioxide and 2.8g magnesium stearate are mixed evenly, are pressed into 1000, obtain described sargassum dispersible tablet.

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Abstract

The invention relates to an isofraxidin crystalline compound and glabrous sarcandra herb dispersible tablets and dropping pills containing the isofraxidin crystalline compound. X-ray powder diffraction spectrogram characteristic peaks of the isofraxidin crystalline compound are measured by Cu-Ka rays and displayed at positions with 2theta being 6.8 degrees, 11.4 degrees, 12.0 degrees, 12.6 degrees, 14.8 degrees, 15.8 degrees, 18.0 degrees, 19.4 degrees, 20.1 degrees, 21.7 degrees, 23.4 degrees, 25.6 degrees, 28.0 degrees, 29.0 degrees and 30.6 degrees. Stability, bioavailability and quality of the glabrous sarcandra herb dispersible tablets and dropping pills are evidently improved, so that medication safety is guaranteed for patients. In addition, the glabrous sarcandra herb dispersible tablets and dropping pills have the advantages of stability in quality, accuracy in dosage, small difference in purity, easiness in implementation of mass mechanical production, high yield and low cost.

Description

technical field [0001] The present invention relates to a kind of inflammatory diseases (such as pneumonia, appendicitis, cellulitis, etc.) of respiratory system and digestive system, which has high curative effect, and is also used for adjuvant treatment of orthopedic diseases and various cancers, specifically The invention relates to an isoferidin crystalline compound and Zhongjiefeng dispersible tablets and Zhongjiefeng dropping pills containing the compound. Background technique [0002] Thunb is the whole herb of Ssrcandrabra Thunb, also known as Jiujiecha, Elderberry, etc. It has the functions of dispelling wind and relieving exterior syndrome, clearing heat and detoxifying, relieving cough and resolving phlegm. Sarcorrhea has a wide range of clinical applications, especially for inflammatory diseases of the respiratory system and digestive system (such as pneumonia, appendicitis, cellulitis, etc.), and is also used for adjuvant treatment of orthopedic diseases and va...

Claims

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Application Information

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IPC IPC(8): C07D311/18A61K36/185A61P1/00A61P11/00A61P19/08A61P35/00
Inventor 刘忠良戴德雄
Owner ZHEJIANG WECOME MEDICINE IND
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