161results about How to "Guarantee drug safety" patented technology

The invention relates to a system and a method for drug placement, distribution and source tracing based on digital tags. The system is formed by connecting the following devices in a wired local network and a wireless local network inside a hospital: a drug placement, distribution and source tracing application server connected with a service database, a plurality of drug placing terminals, a single drug distributing terminal, a source tracing management terminal and an HIS (Hospital Information System) interface terminal interacting information with an HIS system. The system is a set of information system for drug placement, distribution and source tracing constructed by adopting a computer technology, an RFID (Radio Frequency Identification Devices) technology and a two-dimensional code technology. The information system is used for supporting hospital staff to complete two operating steps of drug placement in pharmacies and drug distribution in sick rooms during the drug circulation inside the hospital based on the digital tags, providing scientific and visualized examination means and tools and monitoring and checking each key link during drug placement and distribution. The system can realize the safe control mechanism of drugs for treating patients during the circulation inside the hospital and can reduce the accident potential caused by human mistakes.

The invention discloses a process for extracting ginkgolide, ginkgolide injection and process for preparing same, wherein the extracting process consists of disintegrating the ginkgo leaves, leaching by diluted acetone solution, recovering acetone, removing impurities, extracting and purifying with acetic ether, removing impurities with sodium acetate again, reclaiming acetic ether, recrystallizing in ethanol or methanol, filtering, low temperature drying, solubilizing the bilobalide with hydroxypropyl-beta-cyclodextrin to obtain the bilobalide injection.

The invention relates to a medicine combination information processing method, which comprises the following steps of 1, generating medical advice information, wherein the medical advice information comprises medicine combination information; 2, extracting the medicine combination information from the medical advice information; 3, inquiring the medicine combination information from a medicine reasonable use database; 4, generating inquiry result information. The processing method of the medicine combination information provided by the invention has the advantages that the process of performing reasonableness inspection by a prescription-checking pharmacist through brain memory or literature and guide look-up on the complicated medicine use schemes is completed through computer software, so that the manual checking is changed into automatic checking; the checking efficiency on the specific medicine combination medical advice is greatly improved; the medicine use errors due to memory mistakes and familiar condition of the pharmacists to the medication schemes can be avoided; the medicine use safety of patients is ensured to the maximum degree.

The present invention relates to a method for controlling dichloromethane residue in a polymer microsphere preparation. According to the present invention, during a polymer microsphere preparation process, an external leakage bridge solvent is added to a dichloromethane oil phase and/or a water phase, dichloromethane is carried to the water phase during a microsphere curing process through the external leakage bridge solvent, and finally drying is performed, such that dichloromethane residue in the polymer microsphere preparation can be controlled to less than 600 ppm; the method has characteristics of high efficiency, controllability, stable process, safety, and reasonability; and with the method, the problem of dichloromethane residue in the polymer microsphere preparation can be effectively controlled, and complete form, high drug loading, high encapsulation efficiency and good release effect of microspheres can be maintained.

The invention relates to a method for detecting the contents of dolasetron or isomers in dolasetron salt or dolasetron salt by adopting high performance liquid chromatography. According to the method, normal phase chromatography hu or reversed phase chromatography is adopted to determine the content of isomers of dolasetron or dolasetron salt raw material or preparations (such as oral preparations and injections). The detection method of the invention can better separate dolasetron from isomers, and excellently detects and controls the content of isomers of dolasetron or dolasetron salt raw material or dolasetron preparations (such as oral preparations and injections) to guarantee safety effectiveness of drugs.

The invention discloses a water-soluble vitamin freeze-dried preparation for injection. 1000 bottles of freeze-dried preparations are prepared from the following raw materials: 2.8-3.4g of thiamine mononitrate, 36-44g of nicotinamide, 4.4-5.4g of pyridoxine hydrochloride, 14.8-18.1g of sodium pantothenate compound, 4.4-5.4g of riboflavin sodium phosphate, 102-124g of sodium ascorbate, 54-66mg of biotin, 0.36-0.44g of folic acid, 4.5-6.0mg of vitamin B12, 0.4-0.6g of methyl p-hydroxybenzoate, 280-320g of glycine, 0.4-0.6g of ethylene diamine tetraacetic acid disodium salt and 2000-3000ml of water for injection. The stability of existing sodium pantothenate is obviously improved by the obtained sodium pantothenate compound, thus ensuring that the sodium pantothenate containing water-soluble vitamin freeze-dried preparation for injection has ideal stability and curative effect and further ensuring medication safety of the patients.

A provided daidzein-containing tablet composition comprises daidzein and arginine with the weight ratio of 1:2.5-4. The tablet composition comprises, in parts by weight, 16 parts of daidzein, 40-64 parts of arginine, 5-7 parts of a disintegrating agent, 14-38 parts of a diluent, 0.2-1.0 parts of a lubricant and 0.9-1.6 parts of an adhesive. By employing the above technical scheme, the water-soluble daidzein-containing tablet composition containing daidzein and arginine with the weight ratio of 1:2.5-4 is provided. The invention further provides a specific prescription and a preparation method. An added weak base enables daidzein to relatively well form a relatively stable easily-soluble salt, and thus improvement of dissolution rate is facilitated, and absorption by human body is facilitated. The technology is simple and the prescription quality is reliable, and batch production of the daidzein tablet can be realized.

The invention discloses an intelligent traditional Chinese medicine pharmacy system, and belongs to the technical field of medicine. The intelligent traditional Chinese medicine pharmacy system is characterized by comprising a data interface unit, a prescription management unit and a medicine dispensing unit, which are connected electrically; the data interface unit sends a queried and obtained prescription data signal to the prescription management unit; the prescription management unit sends the reviewed prescription data signal to the medicine dispensing unit; and the medicine dispensing unit receives the prescription data signal and then sends medicines through an intelligent medicine dispensing machine. According to the invention, the safety of the medication is ensured by the arrangement of contraindication compatibility; detailed information of a prescription can be accurately checked before the medicines are dispensed, and subsequent inspection is not required; the entire electronic prescription is standardized in procedure and strong in effectiveness from the treatment to the completion of the medicine dispensing, thereby greatly improving the accuracy of medicine dispensing and the efficiency of medicine dispensing, and saving the time for taking medicines for patients; the medicine dispensing machine is compact in structure, small in space occupation and simple to operate; and the system is controlled by a mechanical automatic program, the prescription is simply written and the medicine packing speed is high.

The invention provides an establishing method of the fingerprint of a traditional Chinese medicinal composition, and a technology for detecting the components of the traditional Chinese medicinal composition by using the fingerprint established through the method. The raw materials of the traditional Chinese medicinal composition comprise Rhizoma Cibotii, Fructus Rosae Laevigatae, Caulis Spatholobi, Philippine flemingia root, Kadsura coccinea, Millettia specisoa Champ, steamed Ligustri Lucidi Fructus, steamed Chinese Taxillus Twig, brine processed semen cuscutae, processed Rhizoma Corydalis, Zanthoxylum nitidum, processed Boswellia carteri and processed myrrh. The establishing method of the fingerprint is characterized in that the retention time of every compound and every medicinal material in the traditional Chinese medicinal composition is detected through high performance liquid chromatography; and the conditions of the high performance liquid chromatography are as follows: octadecylsilane bonded silica is adopted as a stationary phase, a mobile phase comprises acetonitrile and an aqueous phosphoric acid solution with the weight percentage concentration of 0.1%, the volume percentage of the acetonitrile in the mobile phase uniformly increases to 90% from 5% at 0-170 min, the flow velocity is 1 ml/min, the column temperature is 30 DEG C, and the ultraviolet detection wavelength is 254 nm.

The invention discloses a Chinese medicinal granule semi-automatic dispensing method, and relates to the technical field of Chinese medicinal granule dispersing. The method comprises the electronic prescription acquisition step, the electronic prescription analysis step, the medicine bottle taking step, the checking step, the medicine dispensing measurement step and the sealing step. The medicinebottle taking step and the checking step require to be manually completed. The medicine dispensing information of the medicine is manually checked for multiple times in the whole dispensing process through the human-computer interaction interface and the information approval device so that the situation of mistaken medicine dispensing can be avoided. Besides, the medicine can be supplemented in time by the semi-automatic dispensing mode when shortage of the medicine stock is discovered, and the medicine dispensing accuracy can be ensured through multi-level approval. After the electronic prescription information is received, the medicine stock information is checked firstly so that the problem of medicine dispensing interruption caused by insufficient medicine stock can be avoided, the medicine dispensing efficiency can be ensured and the probability of medical dispute can be reduced.

The invention provides a cefotaxime sodium preparation method. The method is characterized in that after an active group of 7-aminocephalosporanic acid is protected by a silanization reagent, subjecting to condensation reaction with AE-active ester to generate cefotaxime acid containing a protecting group; after deprotection of the cefotaxime acid containing the protecting group under the action of a deprotection agent, sequentially subjecting to aqueous-phase acidification and crystallization to obtain cefotaxime acid; subjecting the cefotaxime acid to salification and solvent crystallizationto obtain a pure product of cefotaxime sodium. In a whole technical process, a product degradation process is reduced, product quality is evidently improved, product market competitiveness is improved, and medication safety is further guaranteed.

The invention discloses a method for detecting trace genotoxic impurities in voriconazole. The method comprises the following steps of carrying out derivatization treatment on a to-be-detected by using biphenyl-4-thiophenol and detecting a genotoxic impurity by adoption of a high performance liquid chromatography, wherein the to-be-detected sample is a raw medicine of voriconazole and the genotoxic impurity is (R/S)-4-(1-Bromoethyl)-5-fluorin-6-chlorine-pyrimidine. The method is not capable of realizing the effective separation of voriconazole and related genotoxic impurities , but also capable of realizing the quantitative detection of trace contents, so as to effectively control the contents of the genotoxic impurities in the raw medicines and ensure the medication safety. By adoption ofcommon agents, the method is convenient to operate, good in separation degree and high in sensitivity. The method is capable of realizing detection through common high performance liquid chromatography without purchasing and combining other instruments, so that the operation is convenient and the detection cost is low.

The invention discloses a rapid detection method for drugs on the basis of a handheld Raman spectrometer and a handheld intermediate infrared spectrometer. The rapid detection method comprises the following steps: step 1, establishing Raman spectral models and intermediate infrared spectral models of a plurality of different drug samples; step 2, respectively detecting the Raman spectrums and the intermediate infrared spectrums of to-be-detected samples by utilizing the handheld Raman spectrometer and the handheld intermediate infrared spectrometer; step 3, comparing the Raman spectrums with the Raman spectral models to determine the drug names of the to-be-detected samples according to characteristic peaks, and then comparing the intermediate infrared spectrums with the intermediate infrared spectral models to determine the drug names of the to-be-detected samples according to characteristic peaks. The rapid detection method for drugs on the basis of the handheld Raman spectrometer and the handheld intermediate infrared spectrometer, provided by the invention, can meet the on-site rapid detecting conditions of high portability, solidity, long continuous working time, automation in analysis and judgment, low operation cost, relatively high accuracy, and environmental friendliness.

The invention aims to provide an oil-in-water type hydroquinone emulsion. The emulsion comprises 10-40% (w/w) of an oil phase, 1-5% (w/w) of an oil-in-water type emulsifier, 50-80% (w/w) of a water phase and a pharmaceutically acceptable carrier. The hydroquinone emulsion in the invention has the advantages of high transdermal absorption rate, high bioavailability and the like.

The invention discloses an intelligent medicine delivery machine, and belongs to the technical field of medicine equipment. The intelligent medicine delivery machine is characterized by comprising a display module, a recipe module, an incompatibility module, a maximum dosage module, an inventory module, a medicine module and a medicine delivery module which are arranged on the medicine delivery machine and are electrically connected, wherein the display module transmits electronic recipe signals to the recipe module; the recipe module respectively transmits the obtained recipe detail information to the incompatibility module, the maximum dosage module and the inventory module; the incompatibility module, the maximum dosage module and the inventory module transmit the recipe detail signalspassing the detection to the medicine module; the medicine module transmits the medicine delivery signal to the medicine delivery module; the medicine delivery module controls the medicine delivery and charges the medicine into a medicine box. In the whole process of the electronic recipe from processing to medicine delivery completion, the flow process is specified, the effectiveness is very high; the medicine delivery accuracy and the medicine delivery efficiency are greatly improved; the medicine taking time of a patient is reduced; the structure of the medicine delivery structure is compact; the occupied space is small; the operation is simple and convenient.