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Tegafur gimeracil oteracil potassium capsule and preparation method thereof

A technology of capsules and lubricants, which is applied in the field of medicine, can solve the problems of unimproved drug dissolution, difficulty in industrialization, and large gastrointestinal irritation, and achieve the effects of being beneficial to labor protection, ensuring drug safety, and rapid dissolution

Active Publication Date: 2014-05-28
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] CN101574326A discloses a capsule preparation of S-1 and its preparation method. This invention improves the stability of S-1, but the dissolution rate of the drug has not been improved. In order to ensure rapid dissolution, a large amount of surfactant has been added. The minimum dosage reaches 10mg / capsule, which is more irritating to the gastrointestinal tract. At the same time, the pellet coating technology is adopted, and the production process in the workshop is complicated.
However, a large amount of solvents are used, and industrialization is difficult

Method used

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  • Tegafur gimeracil oteracil potassium capsule and preparation method thereof
  • Tegafur gimeracil oteracil potassium capsule and preparation method thereof
  • Tegafur gimeracil oteracil potassium capsule and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0024]

[0025] Preparation Process:

[0026] The poloxamer is heated and melted at 50°C, and gimeracil is added to the molten liquid, then granulated on the mixed powder of oteracil potassium and tegafur, finally mixed evenly with magnesium stearate, and filled into capsules.

Embodiment 2

[0028]

[0029] Preparation Process:

[0030] The poloxamer is heated and melted at 50°C, and gimeracil is added to the molten liquid, then granulated on the mixed powder of oteracil potassium and tegafur, finally mixed with sodium stearyl fumarate evenly, and filled into capsules.

Embodiment 3

[0032]

[0033] Preparation Process:

[0034] The poloxamer is heated and melted at 50°C, and gimeracil is added to the molten liquid, then granulated on the mixed powder of oteracil potassium and tegafur, finally mixed with sodium stearyl fumarate evenly, and filled into capsules.

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Abstract

The invention discloses a tegafur gimeracil oteracil potassium capsule and a preparation method thereof. The tegafur gimeracil oteracil potassium capsule comprises the following components: tegafur, potassiumoxonate, gimeracil, poloxamer and a lubricating agent. The capsule can be rapidly dissolved, and the preparation method of the capsule is simple to operate and suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a S-1 capsule and a preparation method thereof. Background technique [0002] Tegafur (FT, FT207) is one of the pyrimidine anticancer drugs. It is the prodrug of 5-fluorouracil (5-FU), and has inhibitory effect on most solid tumors. In the body, it can interfere and block the biosynthesis of DNA, RHA and protein, thereby producing its anticancer effect. Basic medical research and clinical observation have proved that tegafur has less toxic and side effects, higher chemotherapy index, less effect on immunosuppression and related immune organs, and is a safe drug that can be used continuously in clinical practice. This product is absorbed through the gastrointestinal tract after oral administration, and the blood concentration reaches the highest peak within 1-3 hours. The duration is longer than that of intravenous administration, so it can exert its better therapeu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/53A61K9/48A61K47/34A61P35/00A61K31/513A61K31/44
Inventor 赵志全郝贵周郑华任英徐健
Owner SHANDONG NEWTIME PHARMA
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