Guizhi Fuling solution solid dispersate

The technology of solid dispersion and cassia tuckahoe is applied in directions such as pharmaceutical combinations, plant raw materials, medical preparations containing active ingredients, etc., and can solve problems such as unfavorable large-scale industrial production, slow dissolution rate of active ingredients, and insignificant curative effect, etc. It is beneficial to large-scale industrial production, the preparation process is simple and easy, and the effect of avoiding the flying of drug dust

Inactive Publication Date: 2007-06-20
SHANGHAI INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the leading product on the market is Guizhi Fuling hard capsules. After the capsule disintegrates, the dissolution rate of active ingredients is slow and incomplete, resulting in poor absorption and insignificant curative effect. In addition, fatty acid active ingredients are easily oxidized, cinnamic acid, cinnamaldehyde, etc. Volatile components are easy to volatilize and disperse, and ordinary powder or granule-filled capsules are difficult to keep such components for a long time, and the stability i

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0030] Example 1

[0031] Preparation of Cinnamon Twig Poria Extract:

[0032] Grind the same amount of cinnamon twigs, poria cocos, peony, moutan bark and peach kernel into coarse powder, mix well, add 8 times the amount of 90% ethanol to extract twice at 75-85°C, each time for one hour, and combine the extractions liquid, filtered, distilled under reduced pressure and recovered ethanol, and concentrated into extract 1; the residue was extracted twice with 6 times of boiling water, each time for one hour, and the extracts were combined, concentrated under reduced pressure to extract 2; extracts 1 and 2 Vacuum-dried, crushed into fine powder, and mixed well.

Example Embodiment

[0033] Example 2

[0034] After heating and melting 350 grams of polyoxyethylene sorbitan monostearate, add 100 grams of cassia twig and poria cocos extract, 50 grams of polyoxyethylene castor oil and glyceryl capric laurate (1:1, weight ratio) , mixed, stirred evenly at 65°C, dissolved, degassed, cooled to 45°C, and filled with 1000 capsules with a capsule liquid filling machine, and the content of the cinnamon twig and poria extract was 0.1 g / capsule.

Example Embodiment

[0035] Example 3

[0036] Mix 200 grams of Guizhi Fuling extract, 80-120 grams of polysorbate, and 180 grams of poloxamer, heat and melt, stir to dissolve, degas, cool to 45°C, and fill 1000 capsules with a capsule liquid filling machine. The content of Poria cocos extract is 0.2 g / grain.

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PUM

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Abstract

A solution-type cinnamon twig-tuckahoe capsule is prepared from the extracts of cinnamon twig and tuckahoe (5-40 Wt%), solubilizer (5-40) and carrier (20-90). It has high solubility and high stability.

Description

technical field [0001] The invention relates to a cinnamon twig and poria preparation. Background technique [0002] Guizhi Fuling Capsule is a compound preparation composed of five traditional Chinese medicines such as Guizhi, Poria cocos, Paeoniae officinalis, Cortex Moutan and peach kernel. In the prescription, Guizhi is the main drug, warming the meridians and promoting blood stasis, supplemented by peach kernels to promote blood circulation and remove blood stasis, paeonol to dissipate blood and promote blood stasis, and to clear stasis and heat, peony to nourish blood and blood, and Poria cocos to eliminate phlegm and diuresis, invigorate dampness and strengthen the spleen, To help eliminate blood stasis. All medicines are used in combination to play the effect of promoting blood circulation and removing blood stasis, and alleviating symptoms. It is clinically used to treat uterine fibroids, chronic pelvic inflammatory mass, dysmenorrhea, ovarian cyst, endometriosis,...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61K36/75A61K9/48A61P15/00A61P15/14A61P13/08
Inventor 顾林金沈航孝
Owner SHANGHAI INST OF PHARMA IND
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