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Gentiopicroside drop pill and preparation method thereof

A technology of gentiopicroside dropping pills and gentiopicroside, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as rebound, easy to produce explosive jaundice, etc., and achieve bioavailability High, conducive to labor protection, low production costs

Inactive Publication Date: 2007-10-17
魏秀华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many adverse reactions of anti-hepatitis B drugs used clinically, such as ganciclovir and other nucleoside drugs, which have strong anti-HBV effects, but long-term use produces drug resistance, especially lamivudine, which will develop after drug withdrawal. Produce severe rebound, prone to fulminant jaundice

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Extraction of pure gentiopicroside

[0027] 1. Take the sieved gentian (Jian gentian or Guan gentian can be used) and grind it into coarse powder.

[0028] 2. Take 1 kg of gentian coarse powder, and use 70% ethanol to reflux extract 3 times by 6, 4, and 4 times, and the extraction time is 2 hours, 1.5 hours, and 1 hour respectively.

[0029] 3. Combine the extracts and filter under reduced pressure. The filtrate was concentrated under reduced pressure to 400ml, and water was added to 2000ml. Cool overnight at 4°C.

[0030] 4. The medicinal solution is centrifuged and filtered. The filtrate was separated by a DM130 type macroporous resin column, and the resin consumption was 600 grams. First wash the resin column with water until the color of the effluent is very light, and the dosage is 4000ml. Then elute with 60% ethanol, collect eluate 2500ml. Flow rate 6ml / min.

[0031] 5. Concentrate the eluent under reduced pressure to an extract, and dry in vacuo to obta...

Embodiment 2

[0038] 1. Extraction of pure gentiopicroside

[0039] 1. Take the sieved gentian (Jian gentian or Guan gentian can be used) and grind it into coarse powder.

[0040] 2. Take 1 kg of gentian coarse powder, and use 85% ethanol to reflux extract 3 times by 8, 6, and 6 times, and the extraction time is 2 hours, 1 hour, and 1 hour respectively.

[0041] 3. Combine the extracts and filter under reduced pressure. The filtrate was concentrated under reduced pressure to 400ml, and water was added to 2000ml. Cool overnight at 4°C.

[0042] 4. The medicinal solution is centrifuged and filtered. The filtrate was separated by a DM130 type macroporous resin column, and the resin consumption was 600 grams. First wash the resin column with water until the color of the effluent is very light, and the dosage is 4000ml. Then elute with 60% ethanol, collect eluent 2500ml. Flow rate 6ml / min.

[0043] 5. Concentrate the eluent under reduced pressure to an extract, and dry in vacuo to obtain ...

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Abstract

A gentiopicroside dropping pill contains gentiopicroside and medicinal groundsubstance components with a dosage proportion by weight of 1:0.5-10. The format of the gentiopicroside dropping pills is 5-500mg / grain. The preparation method of the gentiopicroside dropping pills comprises the following steps: refluxing the gentian coarse powder with ethyl hydrate for extracting, combining and concentrating the extract, standing it overnight at low temperature; performing soup centrifugation and filtration; eluting the filtrate with macroporous resin column; collecting the eluent, concentrating it at reduced pressure to concrete shape, vacuum (freeze) drying it to obtain a crude product; refining it to obtain pure gentiopicroside; selecting medicinal groundsubstances for preparing solid dispersion as a carrier and suspending gentiopicroside in the melting carrier, and then working out gentiopicroside dropping pills by adopting the dropping method. The gentiopicroside dropping pills, as gentiopicroside dropping pill dose, possesses remarkable liver-protection and cholagogic functions. Since the medicament is highly dispersed molecularly in the groundsubstance, and the groundsubstance with water-solubility can accelerate dissolution velocity and absorption rate of drugs, then the bioavailability is high.

Description

technical field [0001] The invention relates to a gentiopicroside dripping pill and a preparation method thereof, belonging to the technical field of traditional Chinese medicine preparations. Background technique [0002] Viral hepatitis is an infectious disease that seriously endangers human health. It is highly contagious and has a high incidence rate. Of the 6 billion people in the world, about 2 billion are infected with HBV, and 350 million are chronically infected with HBV, of which 25% to 40% will eventually die of liver cirrhosis or hepatocellular carcinoma, and the number of deaths due to hepatitis B-related diseases is as high as 100 every year Thousands of cases. 15% to 20% of chronic hepatitis B patients with active virus replication develop liver cirrhosis within 5 years, while the 5-year survival rate of patients with chronic liver cirrhosis is only 55%. The risk of hepatocellular carcinoma in patients with hepatitis B is 200 times higher than that in non-he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/515A61K9/20A61P1/16A61P31/20A61P31/14
Inventor 魏秀华
Owner 魏秀华
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