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Breviscapine infusion preparation and its preparing method

A technology of breviscapine and preparations, which is applied in the field of medicine, can solve the problems of scutellarin, such as poor effect, poor stability, poor clarity, and easy pollution, so as to prevent cross-infection, ensure drug safety, and increase solubility.

Inactive Publication Date: 2003-06-25
上海博泰医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical application of breviscapine is mainly small injections. Clinical application has proved that the effect of small doses of breviscapine is not good, and only large doses (20-40ml or even larger) can be effective. Clinical application requires many small needles to be sawed open and poured. into normal saline or glucose injection, troublesome operation and easy to cause pollution
At the same time, it was also found that the small needle preparation of breviscapine had problems of poor stability and clarity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Breviscapine glucose infusion

[0013] The formula of breviscapine glucose infusion is:

[0014] Breviscapine 20g (calculated as scutellarin)

[0015] Glucose 5kg

[0016] Propylene glycol 200ml

[0017] L-Arginine 40g

[0018] Sodium bisulfite 50g

[0019] EDTA-2Na 26g

[0020] Add water for injection to 100000ml

[0021] The method of preparing breviscapine glucose infusion is as follows:

[0022] Accurately weigh the prescribed amount of sodium bisulfite and EDTA-2Na, add an appropriate amount of water to dissolve them all, add the prescribed amount of scutellarin, stir to form a suspension, add the prescribed amount of propylene glycol, stir evenly, and then add the prescribed amount Dissolve scutellarin completely, adjust the pH to 5.0 with hydrochloric acid, add water to 4000ml, add 0.1% activated carbon, keep warm at 70°C for 20 minutes, filter and decarbonize, and prepare a concentrated solution of 5mg / ml for later use Add the prescribed amoun...

Embodiment 2

[0023] Example 2: Breviscapine Sodium Chloride Infusion

[0024] Breviscapine Sodium Chloride Infusion uses the following weight formula as raw material:

[0025] Breviscapine 20g (calculated as scutellarin)

[0026] Propylene glycol 200ml

[0027] L-Arginine 40g

[0028] Sodium bisulfite 50g

[0029] EDTA-2Na 26g

[0030] Sodium chloride 0.9kg

[0031] Add water for injection to 100000ml

[0032] The method for preparing breviscapine sodium chloride infusion is as follows:

[0033] Accurately weigh the prescribed amount of EDTA-2Na, add an appropriate amount of water to dissolve it all, add the prescribed amount of breviscapine, stir to form a suspension, add the prescribed amount of propylene glycol, stir evenly, and then add the prescribed amount of L-fine acid, adjust the pH to 9.25 to dissolve all scutellarin, adjust the pH to about 5.0 with glacial acetic acid, weigh the prescribed amount of sodium bisulfite, add water to 400ml, add 0.1% activated carbon, keep war...

Embodiment 3

[0035] The formula of breviscapine glucose infusion is:

[0036] Breviscapine 15g (calculated as scutellarin)

[0037] Glucose 5kg

[0038] Propylene glycol 300ml

[0039] L-Arginine 30g

[0040] Sodium bisulfite 40g

[0041] EDTA-2Na 24g

[0042] Add water for injection to 100000ml

[0043] The method of preparing breviscapine glucose infusion is as follows:

[0044] Accurately weigh the prescribed amount of sodium bisulfite and EDTA-2Na, add an appropriate amount of water to dissolve them all, add the prescribed amount of scutellarin, stir to form a suspension, add the prescribed amount of propylene glycol, stir evenly, and then add the prescribed amount L-arginine to dissolve all scutellarin, adjust the pH to 4.5 with hydrochloric acid, add water to 4000ml, add 0.1% activated carbon, keep warm at 80°C for 30 minutes, filter and decarbonize, and prepare a concentrated solution of scutellarin for later use Add the prescribed amount of glucose to 10,000ml of water for i...

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PUM

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Abstract

The Breviscapine infusion preparation is compounded with Breviscapine as main component, glucose or sodium chloride, propylene glycol, L-arginine, sodium bisulphate, EDTA-2Na and water for injection through certain technological process. The preparation is suitable for great dosage application clinically to avoid cross infection caused by intermediate links. In addition, the present invention is clear and stable.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to an intravenous infusion preparation with breviscapine as the main component and a preparation method thereof, specifically breviscapine glucose injection and breviscapine sodium chloride injection and a preparation method thereof. Background technique [0002] Breviscapus is a total flavonoid extracted from the plant Erigron breviscapus (Vaniot) Hand Mazz of Compositae, mainly used in the treatment of cardiovascular and cerebrovascular diseases. At present, it is widely used in clinical practice with definite curative effect, and the total effective rate is more than 90% for coronary heart disease, angina pectoris, cerebral thrombosis, paralysis caused by cerebral infarction and other diseases. The clinical application of breviscapine is mainly small injections. Clinical application has proved that the effect of small doses of breviscapine is not good, and only large ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P9/10
Inventor 张卫东蒋雪涛邹豪
Owner 上海博泰医药科技有限公司
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