Breviscapine injection liquid and its preparing process

A technology of breviscapine and injection, which is applied in the fields of blood diseases, medical formulas, and extracellular fluid diseases, etc. It can solve problems such as inconvenient use, secondary pollution, and high production conditions, so as to avoid secondary pollution and solve stability problems , the effect of ensuring drug safety

Inactive Publication Date: 2006-02-15
HANGZHOU MINSHENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the clinical application of breviscapine is mainly small injections, but it is found that low doses of breviscapine are not effective, and only large doses of breviscapine can be effective
In clinical application, many small needles need to be sawn open and then poured into normal saline or glucose injection for intravenous infusion, which is not only troublesome to operate, but also more likely to cause secondary pollution
In addition, although the breviscapine freeze-dried preparations that have been on the market have greatly improved their stability, they require high production conditions and are more inconvenient to use. Before use, the ampoule bottle needs to be sawed open and injected with water for injection or physiological Vibrated with saline and then added to normal saline or glucose injection for infusion
[0003] The main component of breviscapine, breviscapine, is unstable and easily deteriorates during storage. Currently, all breviscapine injections used in clinical practice have such problems. Therefore, it is urgent to solve the problem of the stability of breviscapine.

Method used

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  • Breviscapine injection liquid and its preparing process
  • Breviscapine injection liquid and its preparing process
  • Breviscapine injection liquid and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: Preparation of Breviscapine Injection

[0042] prescription:

[0043] Breviscapine 60g

[0044] Na 2 S 2 o 3 100g

[0045] EDTANa-Ca 30g

[0046] Glucose 5kg

[0047] Activated carbon for needles 20g

[0048] Make up to 100L with water for injection.

[0049] Process:

[0050] Na 2 S 2 o 3 , EDTANa-Ca was dissolved in 90L water for injection; add the raw materials, and add an appropriate amount of 1N NaOH dropwise while stirring to make it completely dissolved. Add glucose, stir well; add water for injection to nearly 100L, use 10% NaHCO 3 Adjust the pH to 7.8, add activated carbon for needles, stir, stand for half an hour, decarburize, and set the volume to 100L; fine filter, fill with nitrogen and seal, 100mL per bottle; sterilize at 100°C for half an hour to obtain the lamp Florin Injection.

Embodiment 2

[0051] Example 2: Preparation of Breviscapine Injection

[0052] prescription:

[0053] Breviscapine 80g

[0054] Na 2 S 2 o 3 150g

[0055] EDTANa-Ca 50g

[0056] Glucose 8kg

[0057] Activated carbon for needles 30g

[0058] Make up to 100L with water for injection.

[0059] Process:

[0060] Na 2 S 2 o 3 , EDTANa-Ca was dissolved in 90L water for injection; add the raw materials, and add an appropriate amount of 1N NaOH dropwise while stirring to make it completely dissolved. Add glucose, stir well; add water for injection to nearly 100L, use 10% NaHCO 3 Adjust the pH to 8.0, add activated carbon for needles, stir, stand for half an hour, decarburize, and set the volume to 100L; fine filter, fill with nitrogen and seal, 100mL per bottle; sterilize at 100°C for half an hour to obtain the lamp. Florin Injection.

Embodiment 3

[0061] Example 3: Preparation of Breviscapine Injection

[0062] prescription:

[0063] Breviscapine 50g

[0064] Na 2 S 2 o 3 50g

[0065] EDTANa-Ca 10g

[0066] Glucose 6kg

[0067] Activated carbon for needles 10g

[0068] Make up to 100L with water for injection.

[0069] Process:

[0070] Na 2 S 2 o 3 , EDTANa-Ca was dissolved in 90L water for injection; add the raw materials, and add an appropriate amount of 1N NaOH dropwise while stirring to make it completely dissolved. Add glucose, stir well; add water for injection to nearly 100L, use 10% NaHCO 3 Adjust the pH to 7.7, add activated carbon for needles, stir, stand for half an hour, decarburize, and set the volume to 100L; fine filter, fill with nitrogen and seal, 100mL per bottle; sterilize at 100°C for half an hour to obtain the lamp Florin Injection.

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Abstract

The invention discloses a breviscapine injection liquid and its preparing process, wherein each 1000 weight parts of the Breviscapine injection comprises, Breviscapine 0.5-0.9 part, sodium thiosulphate 0.01-2 parts, glucose 50-100 parts, ethylenediaminetetraacetic acid disodium salt 0.01-1 part, adsorbing with activated charcoal 0.1-0.3 part, and balancing water for injection.

Description

(1) Technical field [0001] The invention relates to a breviscapine injection and a preparation method thereof. (2) Background technology [0002] Breviscapus is a total flavonoid extracted from Erigeron breviscapus (Vant) Hand-Mazz plant of Compositae, more than 90% of which is scutellarin, which can expand microvessels, improve microcirculation, improve Myocardial function and blood supply to the heart and brain, reducing blood viscosity, inhibiting platelet aggregation, anti-thrombosis and thrombolysis, and lowering blood lipids. At present, the clinical application of breviscapine is mainly small injections, but it is found in clinical application that low doses of breviscapine are not effective, and only large doses of breviscapine can be effective. In clinical application, many small needles need to be sawn open and then poured into normal saline or glucose injection for intravenous infusion, which is not only troublesome to operate, but also more likely to cause secon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7084A61K9/08A61P9/10A61P7/02A61P3/06
Inventor 唐礼可郭殿武严易青吴春霞
Owner HANGZHOU MINSHENG PHARM CO LTD
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