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Sarcandra glabra extract with anti-influenza virus activity and preparation method thereof

An anti-influenza virus and extract technology, applied in the field of grass coral anti-influenza virus active extract and its preparation, can solve problems such as extraction method research, and achieve the effects of good quantification, interference avoidance and strong pertinence

Active Publication Date: 2018-10-19
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the purpose of their research is to determine the effective chemical components of Coralia praecox, and to do basic work for the formulation of quality standards for Coral praecox extracts, and no targeted research has been done on the extraction method of specific compounds of Coral praecox for anti-influenza virus

Method used

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  • Sarcandra glabra extract with anti-influenza virus activity and preparation method thereof
  • Sarcandra glabra extract with anti-influenza virus activity and preparation method thereof
  • Sarcandra glabra extract with anti-influenza virus activity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] This example provides a separation and extraction method for the anti-influenza virus activity of Coralia pratense, including the preparation of the water extract of Coralus pratense and purification and elution;

[0042] The preparation of the grass coral water extract comprises the following steps: using the grass coral as raw material, placing it in a vacuum Chinese herbal medicine drier and drying it for 1 hour, then crushing the dried grass coral with a pulverizer, and passing the "Chinese Pharmacopoeia" (2015 edition) No. 3 standard drug sieve, the obtained powder is the grass coral powder with a particle size less than or equal to 50 meshes, take 5g of the grass coral powder and put it in a clean round bottom flask, soak it in 150mL deionized water for 30 minutes, and then reflux extraction for 2 hours, Collect the first extract and set aside; add 125mL deionized water to the round bottom flask and soak for 30 minutes, then reflux for 2 hours, collect the second e...

Embodiment 2

[0060] This example provides a separation and extraction method for the anti-influenza virus activity of Coralia pratense, including the preparation of the water extract of Coralus pratense and purification and elution;

[0061] The difference from Example 1 is that the preparation of the grass coral water extract includes the following steps: using grass coral as raw material, drying it in a vacuum herbal medicine dryer for 1.5 hours, and then crushing the dried grass coral with a pulverizer, passing through "Chinese Pharmacopoeia" (2015 edition) No. 3 standard drug sieve, the obtained powder is the grass coral powder with a particle size less than or equal to 50 mesh, take the grass coral powder 6g and place it in a clean round bottom flask, soak it in 180mL deionized water for 30 Minutes, then reflux extraction for 2 hours, collect the first extraction, and set aside; add 150mL deionized water to the round bottom flask and soak for 30 minutes, then reflux extraction for 2 ho...

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Abstract

The invention provides a sarcandra glabra extract with anti-influenza virus activity. Counted by the total weight of the sarcandra glabra extract, the sarcandra glabra extract comprises 0.020-0.040wt%of chlorogenic acid, 0.000-0.008wt% of isofraxidin, 0.025-0.060wt% of quercetin-3-O-beta-D-glucuronide and 0.083-0.158wt% of rosmarinic acid. The invention further provides a preparation method of the sarcandra glabra extract with the anti-influenza virus activity. The preparation method comprises the following steps: performing reflux extraction on sarcandra glabra for two times with deionized water, performing alcohol precipitation to obtain a dry sarcandra glabra water extract, then preparing the dry extract into a sample with a certain concentration, injecting the sample into macroporousadsorption resin, then eluting with an ethanol solution with the concentration of 20%, and collecting an eluate to obtain the sarcandra glabra extract with the anti-influenza virus activity. The sarcandra glabra extract and the preparation method have the advantages as follows: a help is provided for application of the sarcandra glabra extract to fighting against influenza; by the preparation method, the steps are simple and convenient, the operation is easy, quantification can be achieved, the repeatability is high; the preparation method is suitable for application of the extract to the large-scale industrial production process of a medicine in the later stage.

Description

technical field [0001] The invention relates to the technical field of extraction of anti-influenza virus active components of traditional Chinese medicine, in particular to a grass coral anti-influenza virus active extract and a preparation method thereof. Background technique [0002] Influenza virus, referred to as influenza virus, is a representative species of Orthomyxoviridae (Orthomyxoviridae), including human influenza virus and animal influenza virus, mainly through droplets in the air, contact between susceptible and infected persons or with contaminated spread by contact with objects. In recent years, various influenza viruses such as SARS, A H7N9, A H1N1, and bird flu have frequently invaded, are highly contagious, spread rapidly, and are likely to cause a pandemic. Every outbreak of influenza virus has brought great panic to human beings. It is of great significance to find suitable anti-influenza virus drugs efficiently by scientific and technological means. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/216A61K31/37A61P31/16
CPCA61K31/216A61K31/37A61K31/7048A61K36/185A61P31/16A61K2300/00
Inventor 潘馨衷林清
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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