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Method for preparing isofraxidin from herb sarcandra glabra

A technology of isoferidin and sarcocarp, applied in the field of isoferidin preparation, to achieve the effects of reduced co-extraction, low price, and reduced sample preparation costs

Inactive Publication Date: 2017-07-21
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no public report on the preparation process of isoferidinium monomer which is simple, feasible and relatively cheap in preparation cost.

Method used

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  • Method for preparing isofraxidin from herb sarcandra glabra
  • Method for preparing isofraxidin from herb sarcandra glabra
  • Method for preparing isofraxidin from herb sarcandra glabra

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Experimental program
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Embodiment

[0018] 1. Extraction and separation of isoferidin

[0019] Take 12 Kg of the whole herb of Scutellaria scutellaria (about 3 cm / section), put it in a 100 L traditional Chinese medicine extraction tank, add 84 L of water for the first time to infiltrate for 0.5 hours, heat and decoct at 100°C for 2 hours, and add 42 L of water for the second time Heat and decoct at 100°C for 1.5 h, filter through gauze, concentrate to 7 L (equivalent to about 1.7 g / ml medicinal material concentration), extract 4 times with equal volume of cyclohexane-ethyl acetate (1:1), and combine the extracts , concentrated to dryness, ethyl acetate-methanol was dissolved and extracted to recover the soluble part (44 g), 100 g column chromatography silica gel (100-200 mesh) was evenly mixed, the solvent was evaporated at room temperature, 700 g column chromatography silica gel (200-200 mesh) 300 mesh) dry-packed column, petroleum ether II: acetone (15:8) gradient elution for 2 column volumes, every 500 ml was...

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Abstract

The present invention relates to a method for preparing isofraxidin from an herb sarcandra glabra. According to the method, complete plant sarcandra glabra decoction pieces are adopted as a raw material, a lot of non-related components are removed through water heating extraction and liquid-liquid extraction to obtain an isofraxidin crude product enrichment part, and silica gel column chromatography, gel column chromatography decolorization, reverse phase ODS column chromatography fine separation and recrystallization refining are performed so as to obtain the isofraxidin pure product with a purity of more than 99%. According to the present invention, the method has advantages of simple process, simple operation, low production cost, and high product purity.

Description

technical field [0001] The invention relates to a method for preparing isoferidin, which belongs to the technical field of extracting medicinal active ingredients. Background technique [0002] Isoferidin is a natural coumarin component, which has good anti-inflammatory, analgesic and anti-infective effects in vivo (Xiaofeng Niu et al., International Immunopharmacology. 2015. 24:432–439; Ling Liu et al., Immunobiology, 2015, 220 : 406–413; Xiaofeng Niu et al., International Immunopharmacology. 2012. 14: 164–171), which are the characteristic components of the traditional Chinese medicine Zhongjiefeng and Acanthopanax, and are recorded in the 2015 edition of the Chinese Pharmacopoeia ( Chinese Pharmacopoeia, 2015 edition, Part I, pages 206 and 224), used for the quality control of sargassum, Acanthopanax and its preparations. At present, the preparation methods of isoferidin reported in the literature include macroporous resin chromatography (He Xingzhen, Journal of Jiangxi ...

Claims

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Application Information

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IPC IPC(8): C07D311/18
CPCC07D311/18
Inventor 黎雄卢传坚赵瑞芝赵亚
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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