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Method for preparing isofraxidin from acanthopanax senticosus rhizomes

A technology of isoqine and Acanthopanax senticosus, which is applied in the field of preparation of isoqine, can solve the problems of complicated operation, low yield and the like, and achieves the effects of simple process, high yield and strong practicability.

Inactive Publication Date: 2010-10-06
NORTHEAST FORESTRY UNIVERSITY +1
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process is cumbersome to operate, multiple extractions and easy emulsification, low yield

Method used

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Examples

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Effect test

Embodiment 1

[0013] After crushing 500 g of dried and pulverized Acanthopanax roots, use 3000 ml of 50% ethanol solution to extract under reflux at 80° C. for 3 hours, filter the mixture, concentrate the filtrate under reduced pressure to 1 / 2 volume, add 0.6 mol / l aqueous hydrochloric acid, The dosage is 0.5 times the volume of the concentrated solution, the dosage of 1,1-dichloroethane is 2 times the volume of the concentrated solution, the hydrolysis extraction temperature is 85° C., and the time is 5 hours. The 1,1-dichloroethane phase was separated, concentrated to dryness under reduced pressure, and the crude product of isoferidin was obtained, and the extraction rate was 1.25 times that of conventional acid hydrolysis.

Embodiment 2

[0015] After crushing 500 g of dried and pulverized Acanthopanax roots, use 3500 ml of 60% ethanol solution to extract under reflux at 80° C. for 3 hours, filter the mixture, concentrate the filtrate under reduced pressure to 1 / 2 volume, add 0.6 mol / l aqueous hydrochloric acid, The dosage is 0.8 times the volume of the concentrated solution, the dosage of 1,1-dichloroethane is 1.5 times the volume of the concentrated solution, the hydrolysis extraction temperature is 85° C., and the time is 4 hours. The 1,1-dichloroethane phase was separated, concentrated to dryness under reduced pressure, and the crude product of isoferidin was obtained, and the extraction rate was 1.23 times that of traditional acid hydrolysis.

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Abstract

The invention relates to a method for preparing isofraxidin from acanthopanax senticosus rhizomes, which is characterized by comprising the following steps: extracting crushed acanthopanax senticosus rhizomes and an ethanol solution in a certain feed liquid ratio; filtering an obtained mixture; carrying out decompression concentration on a filtrate to 1 / 2 volume to obtain a concentrated solution; then adding an acid aqueous solution and a given volume of 1,1-dichloroethane; separating out a 1,1-dichloroethane phase after hydrolysis extraction is carried out under the heating condition; carrying out the decompression concentration until dryness to obtain the product of the isofraxidin. The operation process hs the main characteristics of rich and available raw materials, simple operation and process, strong practicability and easy industrial operation, and high-yield products can be obtained by single extraction.

Description

Technical field [0001] The invention relates to the field of natural product chemistry, in particular to a method for preparing isoferidin from the rhizome of Acanthopanax senticosus. Background technique [0002] Acanthopanax senticosus (Rupr.et Maxim.) Harms.Syn.Eleutherococccus Senticosus (Rupr.et Maxim.) Maxim) is mainly distributed in Russia, North Korea, Japan, Northeast my country and Hebei. It is a common shrub that grows scattered or in clusters in the broad-leaved mixed forests and forest margins or logging sites in mountainous areas. The roots and rhizomes are the main medicinal parts. It is called "Siberian ginseng" in Russia, "Ezo-ukogi" in Japan, and "Adatogen" in the United States. The whole plant of Acanthopanax senticosus contains a variety of secondary metabolites with physiological activity, and it has a long history of application The famous herbal medicine. In "Compendium of Materia Medica", it is recorded that "Acanthopanax can replenish strength and e...

Claims

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Application Information

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IPC IPC(8): C07D311/18
Inventor 祖元刚杨磊祖柏实郝婧玮刘洋刘婷婷马春慧黄金明王舒雅
Owner NORTHEAST FORESTRY UNIVERSITY
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