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Eggplant root extract and its preparing method and use

An extract and eggplant root technology, applied in the field of eggplant root extract, can solve problems such as large toxic side effects, dysbacteriosis, etc., and achieve the effects of small side effects, blocking absorption, and easy availability of resources

Inactive Publication Date: 2005-10-19
CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing medicines have anti-inflammatory effects. Commonly used medicines for treating periodontitis are antibiotics such as metronidazole, tinidazole, tetracycline, minocycline, spiramycin, amoxicillin, doxycycline, etc., and non-antibiotics such as cloth Luofen, Fenbid, etc. Traditional Chinese medicines such as Qingwei San, Yunvjian, Guchi Pills, etc., but these medicines can easily cause bacterial flora imbalance and have serious side effects

Method used

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  • Eggplant root extract and its preparing method and use
  • Eggplant root extract and its preparing method and use
  • Eggplant root extract and its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Drug efficacy experiment of embodiment 1 anti-inflammatory effective part screening of eggplant root

[0033] 1. Experimental animals:

[0034] Kunming mice (except for the acute toxicity test, half female and half male), the rest are all male, weighing 18-22g; C57BL / 6 mice, all male, weighing 20-25g; Wistar all-male rats, weighing 180-22g 250g. Provided by the Experimental Animal Center of Huazhong University of Science and Technology, certificate number: rat: TJLA-2003-57, 66; mouse: TJLA-2003-41, 58, 67.

[0035] 2. Experimental medicinal material: identified as the root of Solamum melongena L., a plant of Solanaceae.

[0036] 3. Data processing:

[0037] Each group of data is expressed as x±s, and processed with SPSS11.0 statistical software package. The t-test was used for pairwise comparisons, and the analysis of variance was used for multi-group comparisons.

[0038] 4. Screening of anti-inflammatory effective parts of eggplant root

[0039] 4.1. Screening ...

Embodiment 2

[0072] The preparation of embodiment 2 eggplant root extract acidic components

[0073] According to the screening experiment of the anti-inflammatory effective part of eggplant root in Example 1, the results show that the alkali-soluble component is the main effective component of the anti-inflammatory in eggplant root, so the preparation method of the present invention is to extract with alkali extraction and alcohol precipitation method first, and take Precipitate, then extract with ethanol, the detailed preparation method is as follows:

[0074] Take eggplant root slices, add 1% w / w NaOH solution (or KOH solution) to pH 7.5-11.5, extract twice at 80°C for 30 minutes each time, filter, add 10% w / w HCl (hydrochloric acid) solution to the filtrate to adjust Leave the liquid at pH 5-6 to obtain the filtrate and precipitate, wash the precipitate several times with distilled water, and dry at 80°C to obtain a dried product; extract the dried product twice with 95% v / v EtOH (etha...

Embodiment 3

[0075] The HPLC experiment of embodiment 3 eggplant root extract of the present invention

[0076] Preparation of the test sample: Accurately weigh 10 mg of the acidic component of the eggplant root extract of the present invention prepared in Example 2 after being dried at 80°C, put it in a 20ml volumetric flask, add 20ml of methanol accurately, weigh it, ultrasonically treat it for 30min, and weigh it again. Determine the weight, make up the lost weight with methanol, shake well, and let stand. The supernatant was centrifuged and filtered with a 0.45 μm filter membrane.

[0077] Using the same preparation method for the test sample, accurately weigh the solanum root alcohol extract (preparation method: 95% ethanol extraction, degreasing part of petroleum ether, to obtain) to prepare the test sample control (see the attached Figure 4 ).

[0078] Chromatographic conditions: Chromatographic column: ODS (liquid chromatography column) (250mm×4.6mm, 5μm); column temperature 30°...

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Abstract

The present invention provides a kind of eggplant root extract, which is the effective parts of eggplant root and is a kind of acid matter. The eggplant root extract has in its HPLC fingerprint two obvious characteristic peaks, Y1 peak with maintaining time of 16.9+ / -1.0 min and Y2 peak with maintaining time of 18.7+ / -1.0 min. The present invention also provides the preparation process and use of the eggplant root extract. The eggplant root extract of the present invention has antiphlogistic and antiseptic functions and is used in treating periodontitis with determined curative effect, less side effect and low cost.

Description

technical field [0001] The invention provides an extract of eggplant root, which is an acidic substance related to the extract of the medicinal material eggplant root. The invention also provides a preparation method and application of the extract. Background technique [0002] Eggplant is one of the main vegetables in our country. It has been widely planted as early as the sixth century AD, and the detailed cultivation techniques are recorded in "Qi Min Yao Shu". Eggplant root, derived from the dry root of Solamum melongena L. [S. esculentum Dunal; S. melongena L. var. esculentum (Dunal) Nees] of the family Solanaceae, was first recorded in "Kaibao Materia Medica" as a medicine, and it is one of the commonly used medicines of Tujia people One, this taste is sweet, slightly bitter, pungent, and cold in nature. It can dispel wind and dampness, clear away heat and stop bleeding, dissipate blood stasis and reduce swelling, and relieve pain. Indications for rheumatism-heat ar...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P1/02A61P29/00A61P31/04
Inventor 汪鋆植叶红
Owner CHINA THREE GORGES UNIV
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