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Medication of effective part of bee pollen form cole, preparation method and application

A technology of rapeseed bee pollen and drugs, which is applied in the direction of medical preparations containing active ingredients, medical formulas, drug combinations, etc., can solve the problem of few drugs for prostate tumors, and achieve low process production costs, little pollution, and low cost Effect

Inactive Publication Date: 2009-05-20
ZHEJIANG CONBA PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the combination of traditional therapy and drug therapy is mostly used clinically, but there are few drugs available for the treatment of prostate tumors in clinical practice

Method used

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  • Medication of effective part of bee pollen form cole, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 1000 g of rapeseed bee pollen, dry, mechanically pulverize, soak and extract with 95% ethanol at 35°C for five times. Each time for 24 hours, the amount of ethanol added is 3000ml each time, the extract is combined, the extract is concentrated to about 300ml, 40-58% ethanol is added to 600ml, after mixing, petroleum ether is added to extract four times, each time 1500ml, combined, the extract Recovered to dryness, the extract was mixed with 50-100 mesh silica gel, passed through a 50-100 mesh silica gel column, and eluted with petroleum ether-ethyl acetate 10:0-0:10 gradient, and the eluted fraction was thin-layered by TLC Analyze and detect, collect fractions according to TLC test results, mainly collect the fractions eluted with petroleum ether-ethyl acetate 10:0.5~10:3, combine, concentrate to dryness, and obtain 5 g of effective fractions that have the effect of treating prostate tumors.

[0021] A certain amount of diluent is added to the effective part to mak...

Embodiment 2

[0023] Take 1500 g of rapeseed pollen, dry it, grind it mechanically, soak and extract it with 95% ethanol at 40°C for three times. Each time for 24 hours, the amount of ethanol added is 3000ml each time, the extract is combined, the extract is concentrated to about 300ml, and 50-60% ethanol is added to 600ml, after mixing, petroleum ether is added for three times, 1500ml each time, combined, and the extract is recovered To dryness, the extract was mixed with 100-200 mesh silica gel, passed through a 100-200 mesh silica gel column, and petroleum ether-acetone 10:0-0:10 gradient elution, and the eluted fraction was detected by TLC thin-layer chromatography. Collect the fractions according to the TLC test results, collect the fractions eluting with petroleum ether-acetone 10:0.4~10:1.5, through the in vitro PC-3 inhibition test, it has obvious inhibitory effect, and the fractions with obvious inhibitory effect are combined and concentrated to dryness. 11g of the effective part h...

Embodiment 3

[0026] Take 1500 g of rapeseed bee pollen, dry, mechanically pulverize, soak and extract three times with 95% ethanol at 25°C. Each time for 24 hours, the amount of ethanol added is 3000ml each time, the extract is combined, the extract is concentrated to about 300ml, and 50-60% ethanol is added to 600ml, after mixing, petroleum ether is added to extract three times, 2500ml each time, combined, and the extract is recovered To dryness, the extract was mixed with 200-300 mesh silica gel, passed through a 200-300 mesh silica gel column, petroleum ether-chloroform-acetone 10:0:0~1:1:8 gradient elution, and the eluted fraction was analyzed by TLC Thin-layer chromatography detection, collecting the fractions eluted with petroleum ether-chloroform-acetone 10:10:0.1~10:9:1, after the PC-3 in vitro inhibition test, the fractions with obvious inhibitory effect were combined and concentrated to dryness. , to obtain 15g of effective parts with the effect of treating prostate tumors.

[0...

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Abstract

A Chinese medicine for treating prostatic tumor is prepared from rapes pollen through extracting in organic solven and purifying by silica gel column.

Description

technical field [0001] The invention belongs to medicines from effective parts of plants, and mainly relates to medicines prepared from rape (Brassica campestris L) bee pollen (Pollen of Brassin Campestris L) and a preparation method. The prepared medicine can be used in treating prostate tumors. Background technique [0002] Prostate tumor is one of the most common cancers in men. According to cancer statistics in the United States in 1997, among male tumors, prostate cancer ranks first in incidence, accounting for 41%, and ranks second in cancer deaths, accounting for 14%. Over 50 years old The incidence of prostate tumors in male autopsies is as high as 30%. So far, although the incidence of prostate cancer in my country is far lower than that of developed countries in Europe and America, its incidence has increased significantly. With the aging of my country's population and the development of prostate cancer census, more and more patients with prostate cancer will app...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/31A61K9/48A61K9/08A61K9/10A61K9/107A61P13/08A61P35/00A61K133/00
Inventor 张冯敏吴健阮碧芳邱红英姚建标
Owner ZHEJIANG CONBA PHARMA
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