External preparation for skin

Abstract

To provide a skin care preparation synergistically improved in moisturizing effect and epidermal barrier function-improving effect by using specific components in combination.SOLUTION: The skin care preparation for external use comprises a citron extract, especially a sphingolipid-containing citron extract, a Rosa rugosa Thunberg flower extract and a fennel extract. The skin care preparation contains one or more kinds of extracts selected from melissa extract, calendula extract, chamomile extract, horsetail extract, horse chestnut extract, hop extract, carrot extract, mistletoe extract, yarrow extract, sage extract, cornflower extract and rosemary extract.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to an external preparation for skin. [Background technology]

[0002] In recent years, technological developments have been made to increase the added value of topical skin preparations, such as by combining various ingredients. Generally, a wide range of functions are required of topical skin preparations, and in the past, various moisturizing agents have been investigated and included to enhance moisturizing effects, and studies have been conducted to further improve these effects by combining ingredients, etc. (Reference 1).

[0003] However, simply using plant extracts in combination does not synergistically improve their effects, but rather the effects of such combinations are unpredictable, with some having additive effects and others canceling out others. In particular, there is a great need for ingredients that can provide greater effects in smaller amounts in topical skin preparations. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Patent Publication No. 2021-123540 Summary of the Invention [Problem to be solved by the invention]

[0005] An object of the present invention is to provide an external skin preparation that synergistically improves moisturizing effects and epidermal barrier function improving effects by using specific ingredients in combination. [Means for solving the problem]

[0006] As a means for solving the problems of the present invention, the following external skin preparation is provided. (Claim 1) A skin external preparation containing yuzu extract, rugosa rose flower extract, and fennel extract. (Claim 2) A skin external preparation containing sphingolipid-containing yuzu extract, rugosa rose flower extract, and fennel extract. (Claim 3) 3. The topical skin preparation according to claim 1 or claim 2, further comprising one or more extracts selected from melissa extract, calendula extract, chamomile extract, horsetail extract, horse chestnut extract, hop extract, carrot extract, mistletoe extract, yarrow extract, sage extract, cornflower extract, and rosemary extract. (Claim 4) 3. The topical skin preparation according to claim 1 or 2, further comprising melissa extract, calendula extract, chamomile extract, horsetail extract, horse chestnut extract, hop extract, carrot extract, mistletoe extract, yarrow extract, sage extract, cornflower extract and rosemary extract. [Effects of the Invention]

[0007] By using a specific plant extract in combination with the topical skin preparation of the present invention, the moisture content of the epidermal stratum corneum of the skin is synergistically improved, thereby exerting a high moisturizing effect. By using a specific plant extract in combination with the topical skin preparation of the present invention, the amount of transepidermal water loss is synergistically reduced, and a high effect of improving the epidermal barrier function is exhibited. DETAILED DESCRIPTION OF THE INVENTION

[0008] Hereinafter, an embodiment of the present invention will be described.

[0009] (Extract preparation method) First, the preparation method of each plant extract will be described.

[0010] In the present invention, the above-mentioned plants may be extracted raw, but considering extraction efficiency, it is preferable to perform processing such as chopping, drying, and crushing before extraction. Extraction is performed by immersing the plants in an extraction solvent. To improve extraction efficiency, stirring or homogenization in the extraction solvent may be performed. The extraction temperature is preferably from about 5°C to a temperature below the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and extraction temperature, but is preferably about 4 hours to 14 days.

[0011] As the extraction solvent, in addition to water, polar organic solvents such as lower alcohols (e.g., methanol, ethanol, propanol, isopropanol), polyhydric alcohols (e.g., 1,3-butylene glycol, propylene glycol, dipropylene glycol, glycerin), ethers (e.g., ethyl ether, propyl ether), esters (e.g., ethyl acetate, butyl acetate), ketones (e.g., acetone, ethyl methyl ketone), etc. may be used, and one or more of these may be selected and used. Also, physiological saline, phosphate buffer, phosphate-buffered physiological saline, etc. may be used.

[0012] The extracts of the above plants extracted with the above solvents can be incorporated directly into the topical skin preparation of the present invention, or they can be concentrated, dried, and then redissolved in water or a polar solvent, or they can be purified by bleaching, deodorizing, desalting, or fractionating by column chromatography, provided that their skin physiological function-improving effects are not impaired. For storage, the extracts can be lyophilized after purification and then dissolved in a solvent before use. They can also be encapsulated in vesicles such as liposomes or microcapsules.

[0013] (Yuzu extract) The yuzu (Citrus junos) used in the present invention is a tall tree belonging to the Rutaceae family, and any part of the tree, such as the leaves, branches, trunk, bark, roots, flowers, fruit, seeds, and peel, can be used; however, it is preferable to use the fruit, peel, and seeds, and it is even more preferable to use the fruit containing the seeds.

[0014] In the present invention, it is preferable to use a yuzu extract containing sphingolipids, and in that case, it is preferable to use 1,3-butylene glycol as the extraction solvent.

[0015] The yuzu extract used in the present invention can be one that is typically incorporated into topical skin preparations. It is possible to use one extracted directly from the plant, or a commercially available yuzu extract. Examples of commercially available yuzu extracts include CosmeHerbest (registered trademark) Yuzu, BerryBerry (registered trademark) AcneCare, Yuzu Seed Extract-LC, Yuzu Seed Extract-PC, and Yuzu Seed Extract-WSPC (all manufactured by Oryza Oil & Fat Chemical Co., Ltd.), Falcorex Yuzu E and Yuzu Ceramide B (all manufactured by Ichimaru Pharcos Co., Ltd.), Yuzu Extract-ET (manufactured by Yamada Yaken Co., Ltd.), Washism (registered trademark) <Tosa Yuzu>, Yuzu Extract BG, and Yuzu Extract-J (all manufactured by Maruzen Pharmaceuticals Co., Ltd.).

[0016] (Rosan rose flower extract) The rose (Rosa rugosa Thunb.) used in the present invention is a plant of the Rosaceae family, which grows naturally in temperate and subarctic zones in eastern Asia, and is a deciduous shrub that grows in coastal sandy areas, especially in Hokkaido, Japan. In the present invention, rose flowers are used.

[0017] The extraction solvent used to obtain the Rugosa rose flower extract is preferably one or more selected from water, ethanol, and 1,3-butylene glycol, more preferably an aqueous ethanol solution, and most preferably a 50% by volume aqueous ethanol solution.

[0018] In the present invention, the Rugosa rose flower extract is preferably one cultivated in Hokkaido, and organically cultivated ones can also be used.

[0019] The rugosa rose flower extract used in the present invention can be one that is usually incorporated into external skin preparations. It is possible to use one extracted directly from the plant, or a commercially available rugosa rose flower extract. Examples of commercially available rugosa rose flower extracts include Hokkaido Rugosa Rose Extract and Hokkaido Rugosa Rose Extract BG (both manufactured by Sansei Pharmaceutical Co., Ltd.).

[0020] (Fennel extract) Fennel (scientific name: Foeniculum vulgare) is a perennial plant belonging to the Apiaceae family. Components of fennel that can be used for the extract include, for example, leaves, fruits, seeds, and roots, with the fruit being preferred.

[0021] The extraction solvent used to obtain the fennel extract is preferably one or more selected from water, ethanol, and 1,3-butylene glycol, and more preferably an aqueous ethanol solution.

[0022] The fennel extract used in the present invention can be one that is typically incorporated into topical skin preparations. It may be one extracted directly from the plant, or a commercially available fennel extract. Examples of commercially available fennel extracts include fennel extracts alone, such as Fennel Extract (manufactured by Koei Kogyo Co., Ltd.), Fennel Extract W-BG, and Organic Fennel (all manufactured by Maruzen Pharmaceutical Co., Ltd.), as well as mixed plant extracts such as Danox Preservative 7000 Organic (manufactured by International Cosmetic Science Centre aktieselskab), Hexaplant Richter, Cefplant Complex, and Chesplant Complex (manufactured by Chemisches Laboratorium Dr. Kurt Richter GmbH), and Mixed Plant Extract (9) (manufactured by Maruzen Pharmaceutical Co., Ltd.).

[0023] (Melissa extract) Melissa (Melissa officinalis) is a perennial plant belonging to the Lamiaceae family, also known as lemon balm or peppermint. Melissa extract can be made from any part of the plant, including the leaves, stems, roots, and flowers, as well as the whole plant, with the leaves being preferred.

[0024] The extraction solvent used to obtain Melissa extract is preferably one or more selected from water, ethanol, and 1,3-butylene glycol, and more preferably an aqueous ethanol solution.

[0025] The Melissa extract used in the present invention can be one that is typically incorporated into topical skin preparations. It may be extracted directly from the plant, or a commercially available Melissa extract may be used. Examples of commercially available Melissa extracts include Melissa Extract BG-50 (manufactured by Koei Kogyo Co., Ltd.), Melissa Extract-J, Melissa Extract BG-J, Lemon Balm Extract RA (all manufactured by Maruzen Pharmaceutical Co., Ltd.), and Falcorex Melissa B (manufactured by Ichimaru Falcos Co., Ltd.). Alternatively, it may be a mixed plant extract such as Gigawhite CB (manufactured by DSM Co., Ltd.), Hexaplant Richter, and Cefplant Complex (all manufactured by Chemiches Laboratorium Dr. Kurt Richter GmbH), Extrapon 3SPJ (manufactured by Symrise Co., Ltd.), or Mixed Plant Extract (9) (manufactured by Maruzen Pharmaceutical Co., Ltd.).

[0026] (Calendula officinalis extract) Calendula officinalis is an annual or biennial herb belonging to the Asteraceae family, and a closely related species, Calendula arvensis L., can also be used. Components of Calendula that can be used to make Calendula officinalis extract include, for example, flowers, leaves, stems, and the like, with flowers being preferred.

[0027] The extraction solvent used to obtain calendula extract is preferably one or more selected from water, ethanol, and 1,3-butylene glycol, more preferably an aqueous 1,3-butylene glycol solution, and most preferably a 50% by volume aqueous 1,3-butylene glycol solution.

[0028] The calendula officinalis extract used in the present invention may be one that is usually incorporated into topical skin preparations. It may be one extracted directly from the plant, or a commercially available calendula officinalis extract. Examples of commercially available calendula officinalis extract include organic calendula officinalis extract, calendula officinalis extract (all manufactured by Koei Kogyo Co., Ltd.), calendula officinalis extract BG-J (manufactured by Maruzen Pharmaceutical Co., Ltd.), and Falcorex calendula officinalis (manufactured by Ichimaru Falcos Co., Ltd.), as well as mixed plant extracts such as Herbex Anti-Wrinkle (manufactured by Koei Kogyo Co., Ltd.), Falcorex BX44, and Falcorex BX52 (manufactured by Ichimaru Falcos Co., Ltd.).

[0029] (chamomile extract) Chamomile (Matricaria chamomilla) is a plant belonging to the Asteraceae family. Chamomile parts that can be used to make chamomile extract include leaves, stems, flowers, buds, and the entire aboveground plant, with the flowers being preferred.

[0030] The extraction solvent used to obtain chamomile extract is preferably one or more selected from water, ethanol, and 1,3-butylene glycol, and more preferably an aqueous ethanol solution.

[0031] The chamomile extract used in the present invention may be one that is usually incorporated into external skin preparations, and may be one extracted directly from the plant or a commercially available chamomile extract. Commercially available chamomile extracts include VER Chamomile (manufactured by Technoble Co., Ltd.), Organic Chamomile Extract BG-50, Chamomile Extract, Chamomile Extract BG-30, Chamomile Extract LS, Oil-Soluble Chamomile Extract P (all manufactured by Koei Kogyo Co., Ltd.), Chamomile Liquid, Biocell Act Chamomilla B (all manufactured by Ichimaru Falcos Co., Ltd.), Chamomile Extract, Chamomile Extract BG-J, Chamomile Extract LA, and Chamomile Extract SQ-J (all manufactured by Maruzen Pharmaceutical Co., Ltd.). Commercially available chamomile extracts may also be used, such as Hexaplant Richter and Sefplant Complex (manufactured by Chemiches Laboratorium Dr. Kurt Richter GmbH) and Falcorex BX44 (manufactured by Ichimaru Falcos Co., Ltd.), which are mixed plant extracts.

[0032] (Horsetail extract) Horsetail (Equisetum arvense L.) is a perennial fern belonging to the Equisetaceae family. The rhizome, spore stem, and vegetative stem, as well as the whole plant, can be used, but it is preferable to use the whole plant.

[0033] The extraction solvent used to obtain the horsetail extract is preferably one or more selected from water, ethanol, propylene glycol, and 1,3-butylene glycol, and it is most preferred to use 1,3-butylene glycol.

[0034] The horsetail extract used in the present invention can be one that is usually incorporated into topical skin preparations. It is possible to use one extracted directly from the plant, or a commercially available horsetail extract. Examples of commercially available horsetail extracts include horsetail extract, horsetail extract LS (both manufactured by Koei Kogyo Co., Ltd.), horsetail extract BG, horsetail extract ET (manufactured by Yamada Yaken Co., Ltd.), horsetail extract, horsetail extract BG (manufactured by Maruzen Pharmaceutical Co., Ltd.), and VEGETOL water-soluble horsetail (manufactured by Gattefosse SAS). Alternatively, a mixed plant extract such as Falcorex BX46, Falcorex BX50 (both manufactured by Ichimaru Falcos Co., Ltd.), and Phytelene EGX-246 can be used. <bg>, Fiteren EGX-250 <bg>(All manufactured by GREENTECH SA) or the like may also be used.

[0035] (horse chestnut extract) Horse chestnut (Aesculus hippocastanum L.) is a deciduous tree belonging to the family Hippocastanaceae. While any part of the tree, such as leaves, branches, bark, flowers, or fruit, or the whole tree, can be used, it is preferable to use seeds, leaves, or bark, and it is most preferable to use bark.

[0036] The extraction solvent used to obtain the horse chestnut extract is preferably one or more selected from water, ethanol, propylene glycol, 1,3-butylene glycol, and glycerin, and most preferably an aqueous ethanol solution.

[0037] The horse chestnut extract used in the present invention can be one that is typically incorporated into topical skin preparations. It may be extracted directly from the plant, or a commercially available horse chestnut extract may be used. Examples of commercially available horse chestnut extracts include VEGETOL HORSE CHESTNUT MCF 1972 HYDRO (manufactured by Gattefosse SAS), Falcorex Marronnier B (manufactured by Ichimaru Falcos Co., Ltd.), and Horse Chestnut Extract BG-J. Alternatively, it may be a mixed plant extract such as Cobio Phytonic GL (manufactured by Industrias Asociadas, SL), Chess Plant Complex (both manufactured by Chemiches Laboratorium Dr. Kurt Richter GmbH), or Falcorex BX43 (manufactured by Ichimaru Falcos Co., Ltd.).

[0038] (hop extract) Hops (Humulus lupulus L.) is a dioecious, perennial climbing plant in the Moraceae family, and is the source plant of the herbal medicine "hop gland." While any part of the plant, including the leaves, stems, roots, and flowers, can be used, the female flower spike is preferred.

[0039] The extraction solvent used to obtain the hop extract is preferably one or more selected from water, ethanol, propylene glycol, and 1,3-butylene glycol, and it is most preferable to use an aqueous ethanol solution.

[0040] The hop extract used in the present invention can be one that is typically incorporated into topical skin preparations. It is possible to use one extracted directly from plants, or a commercially available hop extract. Commercially available hop extracts include hop extracts made from hops alone, such as Hop Liquid (manufactured by Ichimaru Pharcos Co., Ltd.), Hop Extract (manufactured by Koei Kogyo Co., Ltd.), Hop Extract BG-J (manufactured by Maruzen Pharmaceutical Co., Ltd.), and European Hop Extract (manufactured by Sansei Pharmaceutical Co., Ltd.), as well as mixed plant extracts such as Hexaplant Richter and Ceftplant Complex (both manufactured by Chemiches Laboratorium Dr. Kurt Richter GmbH), Falcorex BX46, and Falcorex BX52 (both manufactured by Ichimaru Pharcos Co., Ltd.).

[0041] (Carrot extract) Carrot extract is made from Daucus carota L., a biennial herb belonging to the Umbeliferae family. While any part of the plant, such as the leaves, stems, and roots, or the whole plant, can be used, it is preferable to use the roots.

[0042] The extraction solvent used to obtain carrot extract is preferably one or more selected from water, ethanol, propylene glycol, and 1,3-butylene glycol, and it is most preferable to use an aqueous ethanol solution.

[0043] The carrot extract used in the present invention can be one that is usually incorporated into topical skin preparations. It may be one extracted directly from the plant, or a commercially available carrot extract. Commercially available carrot extracts may include single-commercial carrot extracts such as Carrot Extract B (manufactured by Ikeda Tohka Kogyo Co., Ltd.) and Falcorex Carrot (manufactured by Ichimaru Falcos Co., Ltd.), or mixed plant extracts such as Cefplant Complex (manufactured by Chemiches Laboratorium Dr. Kurt Richter GmbH) and MS Extract Complex X (manufactured by Maruzen Pharmaceutical Co., Ltd.).

[0044] (Mistletoe extract) European mistletoe (Viscum album L.) is a dioecious, evergreen, semi-parasitic shrub belonging to the Loranthaceae family. Any part of the plant, including leaves, branches, flowers, fruits, and seeds, can be used, but it is preferable to use leaves, branches, or fruits.

[0045] The extraction solvent used to obtain the mistletoe extract is preferably one or more selected from water, ethanol, propylene glycol, and 1,3-butylene glycol, and it is most preferable to use an aqueous ethanol solution.

[0046] The mistletoe extract used in the present invention can be one that is usually incorporated into topical skin preparations. It may be one extracted directly from the plant, or a commercially available mistletoe extract. The commercially available mistletoe extract may be a single mistletoe extract, such as Mistletoe Extract (BG), or a mixed plant extract, such as Cefplant Complex or Hexaplant Richter (all manufactured by Chemiches Laboratorium Dr. Kurt Richter GmbH), MS Extract Complex VII, or Mixed Plant Extract (9) (all manufactured by Maruzen Pharmaceutical Co., Ltd.).

[0047] (Yarrow extract) Yarrow (Achillea millefolium L.) is a perennial plant belonging to the Asteraceae family. Any part of the plant, such as the leaves, stems, roots, or flowers, can be used, but it is preferable to use the flowers or the whole plant.

[0048] The extraction solvent used to obtain yarrow extract is preferably one or more selected from water, ethanol, propylene glycol, and 1,3-butylene glycol, and it is most preferable to use an aqueous ethanol solution.

[0049] The yarrow extract used in the present invention may be one that is usually incorporated into external skin preparations, and may be one extracted directly from the plant or a commercially available yarrow extract. Commercially available yarrow extracts include commercially available yarrow extracts such as Ecofarm Yarrow B, Ecofarm Yarrow E, and Falcorex Yarrow B (all manufactured by Ichimaru Falcos Co., Ltd.), Yarrow Extract, Yarrow Extract K, and Yarrow Extract LS (all manufactured by Koei Kogyo Co., Ltd.), and Yarrow Extract LA (manufactured by Maruzen Pharmaceutical Co., Ltd.). Alternatively, mixed plant extracts such as Cefplant Complex and Hexaplant Richter (all manufactured by Chemiches Laboratorium Dr. Kurt Richter GmbH), Extrapon 1SPJ and Extrapon 3SPJ (manufactured by Symrise Co., Ltd.), MS Extract Complex VII, Mixed Plant Extract (9), and Mixed Plant Extract (12) (manufactured by Maruzen Pharmaceutical Co., Ltd.), and Gigawhite CB (manufactured by DSM K.K.) may also be used.

[0050] (sage extract) Salvia (Salvia officinalis L.) and its varieties (Salvia officinalis var. tenuior) used in sage extract are perennial plants belonging to the Labiatae family. Each part of the plant, such as the leaves, stems, flowers, and roots, or the whole plant can be used, but the leaves are preferred.

[0051] The extraction solvent used to obtain sage extract is preferably one or more selected from water, ethanol, propylene glycol, and 1,3-butylene glycol, and it is most preferable to use an aqueous ethanol solution. It is most preferable to extract with 90% by volume aqueous ethanol, concentrate it to dryness, and then dissolve it in 50% by volume aqueous ethanol.

[0052] The sage extract used in the present invention may be one that is usually incorporated into external skin preparations, and may be one extracted directly from the plant or a commercially available sage extract. Commercially available sage extracts include Ecofarm Sage B, Ecofarm Sage E, Falcorex Sage B, and Falcorex Sage E (all manufactured by Ichimaru Falcos Co., Ltd.), Organic Sage Extract BG-50, Salvia Extract, Salvia Extract LS (all manufactured by Koei Kogyo Co., Ltd.), Salvia Extract, Salvia Extract BG, Salvia Extract BG-J, and Salvia Extract LA (all manufactured by Maruzen Pharmaceutical Co., Ltd.), and Sage Extract BG (manufactured by Yamada Yaken Co., Ltd.). Sage extract alone can also be used, as can mixed plant extracts such as Extrapon 2SPJ and Extrapon 3SPJ (manufactured by Symrise Co., Ltd.), MS Extract Complex XVI, Mixed Plant Extract (12) (manufactured by Maruzen Pharmaceutical Co., Ltd.), Phytelene Complex EGX247 BG, and Phytelene Complex 252 BG (manufactured by GREENTECH SA). BX47, Falcorex BX52 (all manufactured by Ichimaru Falcos Co., Ltd.), etc. may also be used.

[0053] (cornflower extract) Cornflower (Centaurea cyanus L.) is an annual plant belonging to the Asteraceae family. Although any part of the plant, such as the leaves, stems, flowers, and roots, or the whole plant can be used, it is preferable to use the flowers.

[0054] The extraction solvent used to obtain the cornflower extract is preferably one or more selected from water, ethanol, propylene glycol, and 1,3-butylene glycol, and it is most preferred to use 1,3-butylene glycol.

[0055] The cornflower extract used in the present invention can be one that is typically incorporated into topical skin preparations. It may be extracted directly from the plant or a commercially available cornflower extract. Examples of commercially available cornflower extracts include Falcorex Centaurea B, Falcorex Centaurea E (all manufactured by Ichimaru Pharcos Co., Ltd.), and Centaurea Extract BG (all manufactured by Koei Kogyo Co., Ltd.), as well as mixed plant extracts such as Phytelene EGX-244 (manufactured by Greentech SA) and Falcorex BX44 (manufactured by Ichimaru Pharcos Co., Ltd.).

[0056] (rosemary extract) Rosemary extract is made from rosemary (Rosmarinus officinalis L.), an evergreen shrub belonging to the Labiatae family. While any part of the tree, including the leaves, branches, bark, and flowers, as well as the whole tree, can be used, it is preferable to use the leaves.

[0057] The extraction solvent used to obtain rosemary extract is preferably one or more selected from water, ethanol, propylene glycol, and 1,3-butylene glycol, and most preferably an aqueous 1,3-butylene glycol solution.

[0058] The rosemary extract used in the present invention can be one typically incorporated into topical skin preparations. Direct extraction from the plant or commercially available rosemary extract may be used. Examples of commercially available rosemary extracts include Ecofarm Rosemary B, Ecofarm Rosemary E, Falcorex Rosemary B, and Falcorex Rosemary E (all manufactured by Ichimaru Falcos Co., Ltd.), Organic Rosemary Extract BG-50, Mannerwax Extract, Mannerwax Extract LS, and Rosemary Extract S (all manufactured by Koei Kogyo Co., Ltd.), Rosemary Extract (manufactured by GREENTECH SA), and Rosemary Extract BG-J (manufactured by Maruzen Pharmaceutical Co., Ltd.). Alternatively, mixed plant extracts such as Falcorex BX32 and Falcorex BX46 (manufactured by Ichimaru Falcos Co., Ltd.), Phytelene Complex EGX-232 BG, and Phytelene Complex EGX-246 BG (manufactured by GREENTECH SA) may be used.

[0059] [Mixed plant extract (7)] In the present invention, the mixed plant extract (7) described in the Quasi-drug Raw Materials Standards 2021 can also be used as fennel extract, chamomile extract, yarrow extract, hop extract, melissa extract, and mistletoe extract.

[0060] [Mixed plant extract (10)] In the present invention, the mixed plant extract (10) described in the Quasi-drug Raw Materials Standards 2021 can also be used as the fennel extract, carrot extract, and horse chestnut extract.

[0061] In one embodiment, the topical skin preparation of the present invention uses a combination of yuzu extract, rugosa rose flower extract, and fennel extract.

[0062] In one embodiment, the topical skin preparation of the present invention uses a sphingolipid-containing yuzu extract, a rosehip flower extract, and a fennel extract in combination.

[0063] Furthermore, in one embodiment, the topical skin preparation of the present invention contains, in addition to yuzu extract, rosehip flower extract, and fennel extract, one or more extracts selected from melissa extract, calendula extract, chamomile extract, horsetail extract, horse chestnut extract, hop extract, carrot extract, mistletoe extract, yarrow extract, sage extract, cornflower extract, and rosemary extract.

[0064] Furthermore, in one embodiment, the topical skin preparation of the present invention contains, in addition to sphingolipid-containing yuzu extract, rosehip flower extract, and fennel extract, one or more extracts selected from melissa extract, calendula extract, chamomile extract, horsetail extract, horse chestnut extract, hop extract, carrot extract, mistletoe extract, yarrow extract, sage extract, cornflower extract, and rosemary extract.

[0065] Furthermore, one embodiment of the topical skin preparation of the present invention contains, in addition to yuzu extract, rosehip flower extract, and fennel extract, melissa extract, calendula extract, chamomile extract, horsetail extract, horse chestnut extract, hop extract, carrot extract, mistletoe extract, yarrow extract, sage extract, cornflower extract, and rosemary extract.

[0066] Furthermore, one embodiment of the topical skin preparation of the present invention contains, in addition to sphingolipid-containing yuzu extract, rosehip flower extract, and fennel extract, melissa extract, calendula extract, chamomile extract, horsetail extract, horse chestnut extract, hop extract, carrot extract, mistletoe extract, yarrow extract, sage extract, cornflower extract, and rosemary extract.

[0067] The amount of each plant extract added to the skin topical preparation is 1 x 10 -7 % by mass or more is preferable, and 1×10 -6 % by mass or more is more preferable, 5% by mass or less is more preferable, and 1% by mass or less is even more preferable.

[0068] In addition to the above-mentioned components, the topical skin preparation of the present invention may contain optional components used in ordinary cosmetics and quasi-drugs to the extent that the effects of the present invention are not impaired. Specific examples include oils, surfactants, thickeners, preservatives, fragrances, moisturizers, antioxidants, anti-inflammatory agents, antibacterial agents, etc.

[0069] The formulation of the external skin preparation of the present invention is not particularly limited, and may be any of aqueous, oil-based, emulsion-type, and the like.

[0070] The topical skin preparation of the present invention can be prepared by a conventional method.

[0071] The external skin preparation of the present invention can be used in the dosage form of, for example, a lotion, emulsion, or ointment. [Example]

[0072] The present invention will be described in more detail below with reference to examples, but the scope of the present invention is not limited thereto. The blending amounts are in mass % unless otherwise specified.

[0073] First, the method for preparing the extract used in the present invention will be described.

[0074] [Yuzu extract] Yuzu fruit was extracted with an ethanol solution and then filtered.

[0075] [Yuzu extract containing sphingolipids] Dried yuzu fruit was squeezed to obtain a squeezed liquid, which was then mixed with a 70% by mass aqueous solution of 1,3-butylene glycol and insoluble matter was removed.

[0076] [Rosan rose flower extract] The flowers of Rugosa rose cultivated in Hokkaido were soaked in a 50% ethanol solution, extracted, and then filtered. The dry purity was 0.95%.

[0077] [Fennel extract] Fennel fruits were immersed in an ethanol solution for extraction, and the filtrate was frozen and filtered again.

[0078] [Mixed plant extract (7)] 30g of hop female inflorescences, 30g of fennel berries, 30g of chamomile flowers, 30g of yarrow flowers, 5g of peppermint leaves, and 5g of mistletoe berries were mechanically chopped into small pieces, soaked in a mixture of water and ethanol (65:35) containing 1% urea, and left to infuse for one week while stirring at room temperature.Then, the mixture was squeezed and filtered, and water was added to the filtrate to make 1000mL, which was then subjected to further ultrafiltration.

[0079] [Mixed plant extract (10)] 3g of fennel fruit, 5g of horse chestnut bark, and 30g of carrot root were mechanically shredded and immersed in an ethanol solution (3 → 10) containing 0.5% polyethylene glycol monooleate (10E.O.). The mixture was left to infuse at room temperature with stirring for one week, then squeezed and filtered. Water was added to the filtrate to make 100mL, and the mixture was then ultrafiltered.

[0080] [Cornflower extract] Cornflower heads were extracted by immersing them in a 1,3-butylene glycol solution and then filtered.

[0081] [Horsetail extract] Dried whole horsetail plants were immersed in 1,3-butylene glycol solution for 10 days with occasional stirring to extract the extract, which was then filtered.

[0082] [Rosemary extract] Rosemary leaves were immersed in a 50% by volume aqueous solution of 1,3-butylene glycol to extract the extract, which was then filtered.

[0083] [Calendula officinalis extract] Calendula flower heads were immersed in a 50% by volume aqueous solution of 1,3-butylene glycol to extract the extract, which was then filtered, aged, and filtered again.

[0084] [Sage extract] The components obtained by extracting sage leaves with 90% by volume aqueous ethanol solution were redissolved in 50% by volume aqueous ethanol solution and filtered.

[0085] [Moisturizing effect test method] The samples shown in Table 1 were prepared, and the moisture content of the stratum corneum and the transepidermal water loss were measured.

[0086] [Measurement method] (1) Acclimation After washing the inside of the left and right forearms of the subjects, they wiped off the moisture and then rested for 15 minutes in a room adjusted to a temperature of 21±0.5°C and humidity of 50±5% to allow for acclimation. (2) Application A 3 cm x 3 cm area was marked on the inside of each forearm, and 9 μL was dropped onto it using a pipette and applied evenly with a finger wearing a finger cot. (3) Measurement The moisture content of the stratum corneum was measured before application, 30 minutes after application, 1 hour after application, and 2 hours after application using a SKICON-200EX (Yayoi Co., Ltd.). Transepidermal water loss was measured before application and 30 minutes or 2 hours after application using a Vapometer (SWL4081) (Delphin Technologies). The moisture content of the stratum corneum and transepidermal water loss were calculated as relative values, with the value before application set to 1, and are shown in Tables 1 and 2. Because the moisture content of the stratum corneum and transepidermal water loss are easily affected by temperature and humidity on the day of measurement, a group of samples was evaluated on the same day, and the measurement value at the site where the sample was applied before application was also used as the reference for relative values.

[0087] [Table 1]

[0088] [Table 2]

[0089] As shown in Table 1, compared to Comparative Examples 1 to 3, which used each ingredient alone, Example 1 showed an improved moisture content in the stratum corneum and a reduced transepidermal water loss, despite containing one-third the amount of each ingredient. Furthermore, as shown in Table 2, compared to Comparative Examples 4 and 5, Example 2 showed a reduced transepidermal water loss, despite containing half the amount of each ingredient. Therefore, the topical skin preparation of the present invention exhibited a synergistic effect of improving the moisturizing effect and the epidermal barrier function.

[0090] [Example 3] Cream (1) Squalane 10.0 (mass%) (2) Stearic acid 2.0 (3) Hydrogenated palm kernel oil 0.5 (4) Hydrogenated soybean phospholipid 0.1 (5) Cetyl alcohol 3.6 (6) Sphingolipid-containing yuzu extract 0.2 (7) Lipophilic Glyceryl Monostearate 2.0 (8) Glycerin 10.0 (9) Rugosa rose flower extract 0.1 (10) Mixed plant extract (7) 0.5 (11) Calendula officinalis extract 0.05 (12) Phenoxyethanol 0.2 (13) Arginine (20% by weight aqueous solution) 15.0 (14) Sodium Hyaluronate 0.05 (15) Purified water (total amount: 100) (16) Carboxyvinyl polymer (1% by mass aqueous solution) 15.0

[0091] [Example 4] Emulsion (1) Squalane 10.0 (mass%) (2) Methylphenylpolysiloxane 4.0 (3) Hydrogenated palm kernel oil 0.5 (4) Sphingolipid-containing yuzu extract 0.02 (5) Hydrogenated soybean phospholipid 0.1 (6) Polyoxyethylene monostearate Sorbitan (20E.O.) 1.3 (7) Sorbitan monostearate 1.0 (8) Glycerin 4.0 (9) Rugosa rose flower extract 0.3 (10) Mixed plant extract (7) 0.2 (11) Sage extract 0.5 (12) Phenoxyethanol 0.2 (13) Carboxyvinyl polymer (1% by mass aqueous solution) 10.0 (14) Sodium Hyaluronate 0.001 (15) Purified water (total amount: 100) (16) L-arginine (1% by mass aqueous solution) 20.0

[0092] [Example 5] Lotion (1) Ethanol 15.0 (mass%) (2) Polyoxyethylene (40E.O.) hydrogenated castor oil 0.3 (3) Sphingolipid-containing yuzu extract 0.1 (4)Fragrance 0.1 (5) Purified water (total amount: 100) (6) Citric acid 0.02 (7) Sodium citrate 0.1 (8) Glycerin 1.0 (9) Rugosa rose flower extract 0.05 (10) Mixed plant extract (10) 0.1 (11) Cornflower extract 0.2 (12) Hydroxyethyl cellulose 0.1 (13) Sodium hyaluronate 0.003

[0093] [Example 6] Pack (1) Purified water (mass%) (2) Polyvinyl alcohol 12.0 (3) Ethanol 17.0 (4) Glycerin 9.0 (5) Polyethylene glycol (average molecular weight 1000) 2.0 (6) Sphingolipid-containing yuzu extract 1.0 (7) Rugosa rose flower extract 0.6 (8) Mixed plant extract (7) 0.5 (9) Fragrance 0.1

[0094] [Example 7] Facial cleanser (1) Stearic acid 16.0 (mass%) (2) Myristic acid 16.0 (3) Lipophilic Glyceryl Monostearate 2.0 (4) Glycerin 25.0 (5) Sodium hydroxide 7.5 (6) Coconut oil fatty acid amidopropyl betaine 1.0 (7) Purified water (total volume: 100) (8) Sphingolipid-containing yuzu extract 0.05 (9) Rugosa rose flower extract 0.2 (10) Mixed plant extract (7) 0.3

[0095] [Example 8] Cleansing massage cream (1) Squalane 63.0 (mass%) (2) Decaglyceryl monoisostearate 1.5 (3) Decaglyceryl diisostearate 3.0 (4) Sodium N-lauroyl-L-glutamate 0.2 (5) Sucrose monolaurate 0.2 (6) 1,3-butylene glycol 5.0 (7) Xanthan gum 0.2 (8) Purified water (total amount: 100) (9) Ethanol 0.5 (10) Methyl parahydroxybenzoate 0.1 (11) Sphingolipid-containing yuzu extract 0.15 (12) Rugosa rose flower extract 0.1 (13) Mixed plant extract (7) 0.3 (14) Rosemary extract 0.2 (15)Fragrance 0.1

[0096] [Example 9] Cleansing lotion (1) Ethanol 6.5 (mass%) (2) Concentrated glycerin 4.0 (3) Parahydroxybenzoic acid ester 0.01 (4) Decaglycerin monolaurate 0.5 (5) N-coconut oil fatty acid acyl- L-glutamic acid triethanolamine salt 0.03 (6) L-arginine (1 wt% aqueous solution) 0.2 (7)Fragrance 0.05 (8) Sphingolipid-containing yuzu extract 0.15 (9) Rugosa rose flower extract 0.1 (10) Mixed plant extract (10) 0.1 (11) Horsetail extract 0.05 (12) Purified water (total amount: 100)

[0097] [Example 10] Cleansing milk (1) Lauryl glucoside 20.0 (mass%) (2) Glyceryl isostearate 10.0 (3) Isostearic acid 1.0 (4) Oleic acid 1.0 (5) 2-amino-2-methyl-1-propanol 0.8 (6) Acrylic acid / alkyl methacrylate copolymer 0.3 (7) Glycerin 10.0 (8) 1,3-butylene glycol 5.0 (9) Methyl parahydroxybenzoate 0.1 (10) Purified water (total amount: 100) (11) Sphingolipid-containing yuzu extract 0.3 (12) Rugosa rose flower extract 0.2 (13) Mixed plant extract (7) 0.3 (14) Mixed plant extract (10) 0.1 (15) Horsetail extract 0.05 (16) Rosemary extract 0.1 (17)Fragrance 0.1

[0098] [Example 11] Cream (1) Squalane 10.0 (mass%) (2) Stearic acid 2.0 (3) Hydrogenated palm kernel oil 0.5 (4) Hydrogenated soybean phospholipid 0.1 (5) Cetyl alcohol 3.6 (6) Yuzu extract 0.02 (7) Lipophilic Glyceryl Monostearate 2.0 (8) Glycerin 10.0 (9) Rugosa rose flower extract 0.0001 (10) Mixed plant extract (7) 0.001 (11) Mixed plant extract (10) 0.01 (12) Cornflower extract 0.001 (13) Horsetail extract 0.01 (14) Rosemary extract 0.01 (15) Calendula officinalis extract 0.05 (16) Sage extract 0.01 (17) Phenoxyethanol 0.2 (18) Arginine (20% by weight aqueous solution) 15.0 (19) Sodium Hyaluronate 0.05 (20) Purified water (total amount: 100) (21) Carboxyvinyl polymer (1% by mass aqueous solution) 15.0

[0099] [Example 12] Emulsion (1) Squalane 10.0 (mass%) (2) Methylphenylpolysiloxane 4.0 (3) Hydrogenated palm kernel oil 0.5 (4) Sphingolipid-containing yuzu extract 0.02 (5) Hydrogenated soybean phospholipid 0.1 (6) Polyoxyethylene monostearate Sorbitan (20E.O.) 1.3 (7) Sorbitan monostearate 1.0 (8) Glycerin 4.0 (9) Rugosa rose flower extract 0.0001 (10) Mixed plant extract (7) 0.001 (11) Mixed plant extract (10) 0.01 (12) Cornflower extract 0.001 (13) Horsetail extract 0.01 (14) Rosemary extract 0.01 (15) Calendula officinalis extract 0.05 (16) Sage extract 0.01 (12) Phenoxyethanol 0.2 (13) Carboxyvinyl polymer (1% by mass aqueous solution) 10.0 (14) Sodium Hyaluronate 0.001 (15) Purified water (total amount: 100) (16) L-arginine (1% by mass aqueous solution) 20.0

[0100] [Example 13] Lotion (1) Ethanol 10.0 (mass%) (2) Polyoxyethylene (40E.O.) hydrogenated castor oil 0.3 (3) Yuzu extract 0.1 (4)Fragrance 0.1 (5) Purified water (total amount: 100) (6) Citric acid 0.02 (7) Sodium citrate 0.1 (8) Glycerin 3.0 (9) Rugosa rose flower extract 0.05 (10) Fennel extract 0.1 (11) Hydroxyethyl cellulose 0.1 (12) Sodium hyaluronate 0.003< / bg> < / bg>

Claims

1. A skin external preparation containing yuzu extract, rugosa rose flower extract, and fennel extract.

2. A skin external preparation containing sphingolipid-containing yuzu extract, rugosa rose flower extract, and fennel extract.

3. 3. The topical skin preparation according to claim 1 or claim 2, further comprising one or more extracts selected from the group consisting of melissa extract, calendula extract, chamomile extract, horsetail extract, horse chestnut extract, hop extract, carrot extract, mistletoe extract, yarrow extract, sage extract, cornflower extract and rosemary extract.

4. 3. The topical skin preparation according to claim 1 or 2, further comprising melissa extract, calendula extract, chamomile extract, horsetail extract, horse chestnut extract, hop extract, carrot extract, mistletoe extract, yarrow extract, sage extract, cornflower extract and rosemary extract.

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