Cupric ion fluorescence enhancement type molecular probe and preparation method as well as application thereof

Abstract

The invention discloses a cupric ion fluorescence enhancement type molecular probe and a preparation method as well as application thereof. The molecular formula of the probe is shown in the description; 4-methyl-7-hydroxy coumarin is taken as a fluorescence matrix, and reacts with hexamethylene second-amine; a formyl group is introduced at an ortho-position of hydroxy, and an obtained intermediate reacts with o-ethoxyphenol benzylamine; then nitrogen atoms and oxygen atoms are introduced; meanwhile the fluorescent light of a compound is enabled to close, and a specific reaction with cupric ions can be performed. By introducing the nitrogen atoms and the oxygen atoms for performing specific coordination with the cupric ions in the reaction matrix, a cupric ion sensor can quickly cooperate with the cupric ions in a detection process, so that fluorescent light is increased rapidly, thus realizing detection on the cupric ions and being capable of effectively avoiding the disturbance of other metal ions. The fluorescence probe prepared by the method is a high-selectivity fluorescence enhancement type cupric ion chemosensor simple in structure, cheap and easily available in material, easy to prepare and high in yield.

Description

technical field [0001] The invention belongs to the technical field of chemical analysis and detection, and specifically relates to a fluorescent molecular probe, in particular to a copper ion fluorescence-enhanced molecular probe, a preparation method thereof, and an application of the fluorescent molecular probe in identification and detection of heavy metal ions. Background technique [0002] The pollution of heavy metals to the environment and the harm to organisms are becoming more and more serious, which has aroused widespread concern. The detection of heavy metals in the environment and organisms is particularly important. Copper is a common heavy metal element widely present in the environment and organisms, and copper has become one of the important environmental pollutants. Due to the wide application of Cu in electroplating, construction and manufacturing industry, Cu 2+ Serious pollution to the environment. At the same time, copper ion is one of the indispensab...

AI Technical Summary

Problems solved by technology

However, due to the paramagnetism of copper, chemical sensors for copper ions generally have the disadvantage of low fluorescence quantum yield, which is greatly limited in practical applications.

Images