Multi-substituted fluorine-containing pyridine

Abstract

The invention relates to multi-substituted pyridine, in particular to multi-substituted fluorine-containing pyridine which is obtained by performing the reaction of alkynyl imine and benzylamine for 1 to 30h at 60 to 100 DEG C in an organic solvent in the presence of alkali. Various multi-substituted 3-hydrogen, 3-fluorine and 3-trifluoromethyl pyridine derivatives can be synthesized through a cascade reaction of fluoroalkyl alkynyl imine and methylamine. Substituent groups on pyridine rings can be introduced step by step from a very beginning raw material preparation step, and various compounds with bioactivities synthesized by adopting the method can be used for synthesizing insecticides and antibacterial drugs.

Description

technical field

[0001] The invention relates to a multi-substituted pyridine and a new synthesis method, in particular to a new synthesis method of a multi-substituted fluorine-containing pyridine. Background technique

[0002] The pyridine ring structure widely exists in natural compounds and bioactive molecules. Compounds containing this structure may be used as anticancer drugs, antibacterial drugs, antiviral drugs or as pesticides. The pyridine ring is also the core of many widely used ligands Structure. Therefore, a series of pyridine derivatives were synthesized to study the relationship between their structure and activity and to develop more active pyridine analogs. It is well known that the introduction of fluorine atoms or fluorine-containing groups in organic molecules will completely change its chemical, physical and biological properties, so by introducing fluorine elements on the pyridine ring, perhaps the inventors will obtain some useful compounds or material...

Images