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Alpha-cyano-N-benzylpyrazoamide compound, preparation method and pest control agent thereof as active component

A technology of benzyl pyrazole amide and compound, applied in the field of pest control agents, can solve the problems such as the application of α-cyano-N-benzyl pyrazole amide compounds that are not reported in the literature

Inactive Publication Date: 2007-02-28
JIANGSU PESTICIDE RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] But, there is no literature report α-cyano-N-benzylpyrazole amide compound and its application in bactericide, insecticide, acaricide

Method used

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  • Alpha-cyano-N-benzylpyrazoamide compound, preparation method and pest control agent thereof as active component
  • Alpha-cyano-N-benzylpyrazoamide compound, preparation method and pest control agent thereof as active component
  • Alpha-cyano-N-benzylpyrazoamide compound, preparation method and pest control agent thereof as active component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1: Preparation of N-(α-cyano-4-tert-butylbenzyl)-4-chloro-3-ethyl-1-methylpyrazole-5-carboxamide

[0061] A solution composed of freshly prepared 4-chloro-3-ethyl-1-methylpyrazole-5-formyl chloride (12.0g, 0.055mol) and toluene (30ml) was slowly added dropwise under stirring and ice-water bath cooling To a mixture consisting of α-cyano-4-tert-butylbenzylamine (10.0g, 0.05mol), triethylamine (6.0g, 0.06mol) and toluene (200ml). After the dropwise addition, the temperature of the reaction mixture was raised to about 30° C., and the stirring was continued at this temperature. It took about 4-5 hours to follow the chromatographic tracking until the reactant was basically converted completely. The resulting reaction mixture was poured into water (300ml), and the layers were separated. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and precipitated under reduced pressure. The residue was the title compound (Compound No.6 in Ta...

Embodiment 2

[0063] According to the method described in Example 1, other α-cyano-N-benzylpyrazole amide compounds described in Table 1 were synthesized using the corresponding pyrazole carboxyl chloride and α-cyanobenzylamine or its salt.

[0064]

[0065] compound

[0066] 11

[0067] Formulation examples using the compound of the present invention as an active ingredient, which are useful as insecticides, acaricides or fungicides in the fields of agriculture, horticulture and floriculture, will be described below. However, embodiments of the present invention are not limited to the following.

preparation Embodiment 1

[0068] Formulation Example 1: wettable powder

[0069] 20 parts of the compound of the present invention, 10 parts of white carbon black, 55 parts of kaolin, 10 parts of sodium lauryl sulfate and 5 parts of calcium lignosulfonate were uniformly mixed together and jet milled to obtain a wettable powder with an active ingredient of 20%.

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Abstract

The invention discloses an alpha-cyano-N-benzyl pyrazole amide compound and preparing method and pest prevention agent, which is characterized by the following: using organic solvent to react pyrazole formyl chloride and alpha-cyano benzylamine under -10-60 deg.c with general formula as (I); separating (I); adopting the compound or its acid salt as active to prepare pest prevention agent.

Description

technical field [0001] The invention belongs to the field of pesticides, and relates to an α-cyano-N-benzyl pyrazole amide compound. The invention also relates to a preparation method of the compound and a pest control agent using the compound as an active ingredient. Background technique [0002] Heterocyclic compounds occupy a very important position in the research and development of pesticides, especially nitrogen-containing heterocyclic compounds, many of which have been developed as pesticides and widely used in agriculture and horticulture, among which there are not only fungicides, herbicides, And there are also highly effective insecticides and miticides. Among them, certain N-substituted pyrazole amide derivatives have also been successfully developed as insecticides and acaricides. [0003] US 4,950,668 discloses that N-benzylpyrazole-5-amide derivatives such as tebufenpyrad have insecticidal and acaricidal activities. [0004] [0005] ...

Claims

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Application Information

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IPC IPC(8): C07D231/14A01N43/56
Inventor 徐尚成马海军倪珏萍郭丽琴刁亚梅王凤云万琴刘丽
Owner JIANGSU PESTICIDE RES INST
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