31 results about "Halopropane" patented technology

The invention provides a reaction type antistatic agent. The antistatic agent is generated by reacting an intermediate which is synthesized under the alkaline condition based on polyethylene glycol and epoxy halopropane as raw materials with trialkylamine haloid, wherein the molecular weight of polyethylene glycol is 400-2,000. The invention also provides a preparation method of the reaction type antistatic agent, which comprises the following steps of: (1) synthesizing the intermediate at 40-60 DEG C under the alkaline condition by taking polyethylene glycol and epoxy halopropane as the raw materials; and (2) reacting the intermediate with trialkylamine haloid in an alcohol solvent at 20-40 DEG C to obtain the reaction type antistatic agent. The invention also provides an antistatic polyurethane material which is prepared by mixing and pouring a raw material A and a raw material B, wherein the raw material A comprises polyhydric alcohol, a catalyst, a foaming agent, a chain extender and the reaction type antistatic agent; and the raw material B is isocyanate.

The invention discloses an environment-friendly synthesis method for cinacalcet. The cinacalcet is prepared by reacting R(+)-1-naphthyl ethamine and [3-(3'-trifluoromethyl)phenyl]-1-halopropane or [3-(3'-trifluoromethyl)phenyl]-1-propylsulfonate serving as raw materials with water serving as medium under the action of a phase-transfer catalyst. The process has the advantages of reducing the cost, along with high yield, no any organic solvent during the reaction, and low environmental pollution, and thus is a synthesis method suitable for industrialization.

The invention discloses a cationic type gemini fluorinated surfactant based on perfluorinated nonene and perfluorinated hexene and a preparation method of the cationic type gemini fluorinated surfactant. The preparation method comprises the following steps of: with the perfluorinated nonene or perfluorinated hexene as a raw material, condensing the perfluorinated nonene or perfluorinated hexene with p-hydroxybenzoic acid, and carrying out chlorination on a matter obtained after condensation and thionyl chloride to prepare perfluorinated alkene oxyl benzoyl chloride; condensing the perfluorinated alkene oxyl benzoyl chloride without separation with 2-dimethylamino ethanol, 3-dimethylamino propanol, 2-dimethylamino ethylamine and 3-dimethylamino propylamine to obtain perfluorinated alkene oxyl benzoate or perfluorinated alkene oxyl benzamide with tertiary amine at an alkanol part or amine part; and finally, condensing the perfluorinated alkene oxyl benzoate or perfluorinated alkene oxyl benzamide with 1,2-dihaloethane, 1,3-dihalopropane, 1,4-dichlorobutane, 1,5-dichloropentane or 3-oxa-1,5-dichloropentane to prepare a quaternary ammonium gemini fluorinated surfactant. The synthesized compound is high in surface activity and is low in critical micelle concentration, has the characteristics of simpleness in synthesization, low cost and the like and has good application prospect.

The invention concerns a method for producing 2,3,3,3-tetrafluoropropene comprising: a fluoridation reaction of a halopropane and/or halopropene into 2,3,3,3-tetrafluoropropene by means of hydrogen fluoride; the recovery of a gas stream resulting from the reaction; the cooling and partial condensation of the gas stream resulting from the reaction into a partially condensed stream; the separation of the partially condensed stream into a gas fraction and a liquid fraction; the compression of the gas fraction into a compressed gas fraction; the compression of the liquid fraction into a compressed liquid fraction; the distillation of the compressed gas fraction and compressed liquid fraction in order to provide a stream of 2,3,3,3-tetrafluoropropene, a stream of hydrochloric acid, and a stream of unreacted hydrogen fluoride. The invention also concerns an installation suitable for implementing said method.

The invention relates to a preparation method of end-mercapto polyether, belonging to adhesive field. The deficits of the present preparation method of end-mercapto polyether: the solubleness of product obtained by reacting polyalkylene diol and epoxy halopropane in sodium hydrosulphide is poor and the availability of sodium hydrosulphide is reduced, therefore the difficulty is added to the post-treatment. The chloride polyether, sodium hydrosulphide and alcohol material are mixed together and react for 2-5 hours at boiling point of alcohol material to 40 degree, wherein the quantity relative ratio of alcohol material and sodium hydrosulphide is 3-18:1, the quantity relative ratio of chloride polyether and sodium hydrosulphide is 1:2-3.5. The availability of the sodium hydrosulphide is greatly increased. In addition, the displacement reaction of chloride polyether and sodium hydrosulphide occurs in alcohol material, the reaction temperature is reduced, so as to reduce the energy consumption.

The invention relates to an alkaline environmental-friendly zinc-plating additive for changing a cyanogen process into a cyanogen-free process. The additive comprises the following substances: at least one organic heterocyclic compound and derivative, at least one organic amine-epoxy halopropane polycondensate, wherein the molar ratio of the organic heterocyclic compound and derivative to an alicyclic amine compound and the polycondensate is 0.5-4.0:0.5-5.0. The additive overcomes the defects of severe environmental pollution caused by the conventional cyanogen zinc plating process. After sodium cyanide is stopped adding, the cyanogen zinc plating process can be gradually changed into a cyanogen-free environmental-friendly alkaline zinc plating process on the premise of not influencing normal production by adopting the zinc-plating additive.

A process for the preparation of 2-chloro-1,1,1,3,3,3-heptafluoropropane is disclosed which involves (a) contacting a mixture comprising hydrogen fluoride, chlorine, and at least one starting material selected from the group consisting of halopropenes of the formula CX₃CCl═CX₂ and halopropanes of the formula the CX₃CClYCX₃, wherein each X is independently F or Cl, and Y is H, Cl or F (provided that the number of X and Y which are F totals no more than six) with a chlorofluorination catalyst in a reaction zone to produce a product mixture comprising CF₃CClFCF₃, HCl, HF, and underfluorinated halogenated hydrocarbon intermediates. The process is characterized by said chlorofluorination catalyst comprising at least one chromium-containing component selected from (i) a crystalline alpha-chromium oxide where at least 0.05 atom % of the chromium atoms in the alpha-chromium oxide lattice are replaced by nickel, trivalent cobalt or both nickel and trivalent cobalt, provided that no more than 2 atom % of the chromium atoms in the alpha-chromium oxide lattice are replaced by nickel and that the total amount of chromium atoms in the alpha-chromium oxide lattice that are replaced by nickel and trivalent cobalt is no more than 6 atom %, and (ii) a fluorinated crystalline oxide of (i). Also disclosed is a process for the manufacture of a mixture of HFC-227ea and hexafluoropropene by reacting a starting mixture comprising CFC-217ba and hydrogen in the vapor phase at an elevated temperature, optionally in the presence of a hydrogenation catalyst. This process involves preparing the CFC-217ba by the process described above.

The invention provides a preparation method of sodium valproate, and belongs to the technical field of medicine synthesis. The method comprises the following steps: by taking ethyl valerate as a raw material, adding a methyl tert-butyl ether solution of a pyrrole metal reagent into an ether solution of ethyl valerate, then adding halopropane, carrying out an alkylation reaction, adding a weakly acidic solution in a dropwise manner to terminate the reaction after the reaction is finished, and washing with water to obtain an intermediate product; and adding a sodium hydroxide solution into the alcohol solvent of the intermediate product, carrying out a saponification reaction, and purifying to obtain sodium valproate after the saponification reaction is finished. The method is short in reaction route, high in total yield, easily available in raw materials, low in cost, high in operability and suitable for industrialization. The total molar yield of sodium valproate prepared by the methodis greater than or equal to 86.0%, and the purity of the final product is greater than or equal to 99.5%.

The invention discloses a synthetic method of imrecoxib. The synthetic method comprises the following steps: allowing (E)-1-p-methanesulfonylphenyl-1-nitro-2-p-tolylethylene and ethyl isocyanoacetateto undergo a condensation and cyclization reaction in a system containing an alkali reagent and a solvent; allowing the obtained 3-p-methylphenyl-4-p-methylsulfonylphenylpyrrole-2-carboxylate to undergo a reducing reaction at -78 DEG C in a system containing a reducing reagent and a solvent; allowing the obtained 3-p-methylphenyl-4-p-methylsulfonylphenylpyrrole-2-carbaldehyde to undergo an oxidation reaction in a system containing a hydrogen peroxide solution and a solvent; and allowing the obtained 3-p-methylphenyl-4-p-methylsulfonylphenyl-3-pyrrolidin-2-one and 1-halopropane or a hydrocarbonpropyl sulfonate derivative to undergo a substitution reaction in a system containing an alkali reagent and a solvent to obtain the imrecoxib. The synthetic method of the imrecoxib has the beneficialeffects that the reaction steps are simplified and optimized and the process is simple in operation, thereby being helpful to reduce cost; reaction impurities are less and controllable, so greennessand environment-friendliness are embodied; and initial raw materials and the used reagents are easily available.

The invention discloses a preparation method of an epoxy group-containing phthalonitrile monomer, and relates to the technical field of organic synthesis. The method comprises the following steps: blending phenolic hydroxyl group-containing phthalonitrile and epoxy halopropane serving as raw materials in alkali liquor for a reaction under the catalysis of quaternary ammonium salt to obtain a mixed solution of an epoxy group-containing phthalonitrile monomer, and purifying the mixed solution to obtain the epoxy group-containing phthalonitrile monomer. According to the invention, the melting temperature of the phthalonitrile monomer is reduced, and the processing window of phthalonitrile is widened, so the application field of phthalonitrile resin is expanded.

The invention discloses a method for synthesizing optically-pure chiral sec-allyl alcohol by means of an improved Julia alkylation reaction, and belongs to the technical field of organic synthesis. The method comprises the specific technological steps that high optically-pure epoxy halopropane is subjected to hydroxyl protection after tetrazole-thione nucleophilic ring opening is performed and oxidized into an improved Julia alkylation reagent to be condensed with aldehyde or ketone, hydroxyl protection is removed, and a series of high optically-pure chiral sec-allyl alcohol containing E-type carbon-carbon double bonds can be obtained.

The invention provides a preparation method of 4,6-dihalo-2-(propylthio)-5-aminopyrimidine disclosed as structural formula II, which comprises the following steps: 1) reacting a compound disclosed as structural formula V with 1-propyl hydrosulfide or 1-halopropane in the presence of alkali to obtain 5-halo-2-propylthiopyrimidine disclosed as structural formula IV; 2) reacting the 5-halo-2-propylthiopyrimidine disclosed as structural formula IV with ammonia gas, ammonia water or ammonium salt in the presence or absence of alkali to obtain 5-amino-2-propylthiopyrimidine disclosed as structural formula III; and 3) reacting the 5-amino-2-propylthiopyrimidine disclosed as structural formula III with a halogenating reagent to obtain the 4,6-dihalo-2-(propylthio)-5-aminopyrimidine disclosed as structural formula II. The preparation method has the advantages of short reaction route, high product purity and cheap and accessible raw materials, and is suitable for industrialized mass production. In the formulae, Q and X are respectively and independently selected from chlorine, bromine or iodine; and Y is OH or SH.

The invention relates to a preparation method for intermediates 3-isopropylfuranone derivatives of a blood-pressure-reducing medicine aliskiren, and belongs to the technical field of medicine preparation methods. The method is characterized by comprising: taking (2S,4S)-2-amino-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methylcaproic acid (compound II) as a raw material, and performing amino protection to obtain a compound III; reacting the compound III with bromochloromethane to obtain a compound IV; performing reduction and ring-closing reaction on the compound IV to obtain a compound VI; reacting the compound VI with diethyl malonate to obtain a compound VII; reacting the compound VII with a 2-halopropane to obtain a compound VIII; and performing decarboxylation on the compound VIII to obtain a compound IX. The method has the advantages of raw material easy availability, operation simpleness, method reliability, low cost, easy industrialization and the like.

The invention relates to a preparation method of polysulfate type epoxy resin. The preparation method comprises the steps of (1) preparing polysulfate of which the number-average molecular weight is 1000-10000 g/mol and the terminal group is hydroxyl; (2) heating and dissolving polysulfate in epoxy halopropane; (3) continuing to add a ring-opening catalyst, and enabling epoxy halopropane to react with polysulfate; (4) continuing to add a ring-closed catalyst, and enabling the end group of the polysulfate to be changed into an epoxy structure; and (5) separating out the product, and purifying. The preparation method provided by the invention can realize large-scale industrial production, and has the advantages of simple post-treatment process and small pollution.