31 results about "Halopropane" patented technology

Dehydrohalogenation processes for the preparation of fluoropropenes from corresponding halopropanes, in which the fluoropropenes have the formula CF3CY═CXNHP, wherein X and Y are independently hydrogen or a halogen selected from fluorine, chlorine, bromine and iodine; and N and P are independently integers equal to 0, 1 or 2, provided that (N+P)=2.

A process for the preparation of 2-chloro-1,1,1,3,3,3-heptafluoropropane is disclosed which involves (a) contacting a mixture comprising hydrogen fluoride, chlorine, and at least one starting material selected from the group consisting of halopropenes of the formula CX3CCI═CX2 and halopropanes of the formula the CX3CCIYCX3, wherein each X is independently F or Cl, and Y is H, Cl or F (provided that the number of X and Y which are F totals no more than six) with a chlorofluorination catalyst in a reaction zone to produce a product mixture comprising CF3CCIFCF3, HCI, HF. and underfluorinated halogenated hydrocarbon intermediates. The process is characterized by said chlorofluorination catalyst comprising at least one chromium-containing component selected from (i) a crystalline alpha-chromium oxide where at least 0.05 atom % of the chromium atoms in the alpha-chromium oxide lattice are replaced by nickel, trivalent cobalt or both nickel and trivalent cobalt, provided that no more than 2 atom % of the chromium atoms in the alpha-chromium oxide lattice are replaced by nickel and that the total amount of chromium atoms in the alpha-chromium oxide lattice that are replaced by nickel and trivalent cobalt is no more than 6 atom %, and (ii) a fluorinated crystalline oxide of (i). Also disclosed is a process for the manufacture of a mixture of HFC-227ea and hexafluoropropene by reacting a starting mixture comprising CFC-217ba and hydrogen in the vapor phase at an elevated temperature, optionally in the presence of a hydrogenation catalyst. This process involves preparing the CFC-217ba by the process described above.

A kind of synthetic method of Erecoxib, step: with (E)-1-p-methylsulfonylphenyl-1-nitro-2-p-tolylethylene and isocyanoacetate in the mixture of alkali reagent and solvent The condensation cyclization reaction is carried out in the system; the obtained 3-p-methylphenyl-4-p-methylsulfonylphenylpyrrole-2-carboxylate is reduced at -78°C in a system of reducing agent and solvent Reaction; The obtained 3-p-methylphenyl-4-p-methylsulfonylphenylpyrrole-2-formaldehyde is oxidized in the system of hydrogen peroxide and solvent; the obtained 3-p-methylphenyl-4- Perform substitution reaction between p-methylsulfonylphenyl-3-pyrrolidin-2-one and 1-halopropane or hydrocarbon sulfonate propyl ester derivatives in a system of alkali reagent and solvent to obtain Erecoxib. The reaction steps are simplified and optimized, and the process operation is simple, which helps to reduce the cost; the impurities in the reaction are less and controllable, reflecting green environmental protection; the starting materials and the reagents used are easily available.

The invention provides a preparation method of 4,6-dihalo-2-(propylthio)-5-aminopyrimidine disclosed as structural formula II, which comprises the following steps: 1) reacting a compound disclosed as structural formula V with 1-propyl hydrosulfide or 1-halopropane in the presence of alkali to obtain 5-halo-2-propylthiopyrimidine disclosed as structural formula IV; 2) reacting the 5-halo-2-propylthiopyrimidine disclosed as structural formula IV with ammonia gas, ammonia water or ammonium salt in the presence or absence of alkali to obtain 5-amino-2-propylthiopyrimidine disclosed as structural formula III; and 3) reacting the 5-amino-2-propylthiopyrimidine disclosed as structural formula III with a halogenating reagent to obtain the 4,6-dihalo-2-(propylthio)-5-aminopyrimidine disclosed as structural formula II. The preparation method has the advantages of short reaction route, high product purity and cheap and accessible raw materials, and is suitable for industrialized mass production. In the formulae, Q and X are respectively and independently selected from chlorine, bromine or iodine; and Y is OH or SH.

The invention discloses a cationic type gemini fluorinated surfactant based on perfluorinated nonene and perfluorinated hexene and a preparation method of the cationic type gemini fluorinated surfactant. The preparation method comprises the following steps of: with the perfluorinated nonene or perfluorinated hexene as a raw material, condensing the perfluorinated nonene or perfluorinated hexene with p-hydroxybenzoic acid, and carrying out chlorination on a matter obtained after condensation and thionyl chloride to prepare perfluorinated alkene oxyl benzoyl chloride; condensing the perfluorinated alkene oxyl benzoyl chloride without separation with 2-dimethylamino ethanol, 3-dimethylamino propanol, 2-dimethylamino ethylamine and 3-dimethylamino propylamine to obtain perfluorinated alkene oxyl benzoate or perfluorinated alkene oxyl benzamide with tertiary amine at an alkanol part or amine part; and finally, condensing the perfluorinated alkene oxyl benzoate or perfluorinated alkene oxyl benzamide with 1,2-dihaloethane, 1,3-dihalopropane, 1,4-dichlorobutane, 1,5-dichloropentane or 3-oxa-1,5-dichloropentane to prepare a quaternary ammonium gemini fluorinated surfactant. The synthesized compound is high in surface activity and is low in critical micelle concentration, has the characteristics of simpleness in synthesization, low cost and the like and has good application prospect.

The invention provides a reaction type antistatic agent. The antistatic agent is generated by reacting an intermediate which is synthesized under the alkaline condition based on polyethylene glycol and epoxy halopropane as raw materials with trialkylamine haloid, wherein the molecular weight of polyethylene glycol is 400-2,000. The invention also provides a preparation method of the reaction type antistatic agent, which comprises the following steps of: (1) synthesizing the intermediate at 40-60 DEG C under the alkaline condition by taking polyethylene glycol and epoxy halopropane as the raw materials; and (2) reacting the intermediate with trialkylamine haloid in an alcohol solvent at 20-40 DEG C to obtain the reaction type antistatic agent. The invention also provides an antistatic polyurethane material which is prepared by mixing and pouring a raw material A and a raw material B, wherein the raw material A comprises polyhydric alcohol, a catalyst, a foaming agent, a chain extender and the reaction type antistatic agent; and the raw material B is isocyanate.

Disclosed is a preparation method of the lycopene intermediate 3-methyl-4,4-dialkoxy-1-butaldehyde. The preparation method comprises the following steps: (1) reacting 2-methyl-3,3-dialkoxy-1-halopropane with magnesium powder in the solvent of anhydrous tetrahydrofuran at a temperature of 45˜65° C. to generate a mixture of Grignard reagents under the protection of an inert gas; and (2) adding N,N-disubstituted carboxamide to the mixture of Grignard reagents and reacting at a temperature of 10° C.˜35° C. to obtain 3-methyl-4,4-dialkoxy-1-butaldehyde. The process route of the present invention is simple and direct, the operation is easy, the conditions are mild and the yield is good, and thus the invention has commercial value.

The invention discloses preparation methods of an imrecoxib intermediate and imrecoxib. The preparation method of N-propyl-N-[2-oxo-2-(4-mesylphenyl)]ethyl-4-methyl phenyl acetamide as the imrecoxib intermediate comprises the following steps of performing substitution reaction on 2-amino-1-p-methylsulfonyl acetophenone and 1-halopropane in a system of an acid binding agent and a solvent to obtain2-propylamino-1-p-methylsulfonyl acetophenone; and enabling 2-propylamino-1-p-methylsulfonyl acetophenone and p-methyl phenylacetyl halide to perform amidation in the system of the acid binding agentand the solvent to obtain N-propyl-N-[2-oxo-2-(4-mesylphenyl)] ethyl-4-methyl phenyl acetamide. The preparation method of the imrecoxib comprises the following step of performing condensation and cyclization reaction on N-propyl-N-[2-oxo-2-(4-mesylphenyl)] ethyl-4-methyl phenyl acetamide in a system of an alkaline matter and a solvent on the basis. The synthetic route provided by the invention enables the reaction process to be more simple and post-treatment separation to be easier and is capable of acquiring ideal yield.

The invention discloses an acid-modified melamine resin for a UV (ultraviolet) paint, which is composed of the following components in parts by weight: 6-13 parts of melamine, 20-50 parts of photocuring agent, 0.01-1 part of polymerization inhibitor, 0.01-1 part of catalyst, 2-5 parts of organic solvent and 20-60 parts of R-epoxy halopropane. The acid-modified melamine resin is used for a UV paint, and can effectively enhance the wear resistance, hardness and heat resistance of the UV paint; and thus, the wear value of the UV paint can reach 0.03g / 100r, the hardness can reach 4H, and the heat resistance can reach 360 DEG C.

The invention concerns a method for producing 2,3,3,3-tetrafluoropropene comprising: a fluoridation reaction of a halopropane and / or halopropene into 2,3,3,3-tetrafluoropropene by means of hydrogen fluoride; the recovery of a gas stream resulting from the reaction; the cooling and partial condensation of the gas stream resulting from the reaction into a partially condensed stream; the separation of the partially condensed stream into a gas fraction and a liquid fraction; the compression of the gas fraction into a compressed gas fraction; the compression of the liquid fraction into a compressed liquid fraction; the distillation of the compressed gas fraction and compressed liquid fraction in order to provide a stream of 2,3,3,3-tetrafluoropropene, a stream of hydrochloric acid, and a stream of unreacted hydrogen fluoride. The invention also concerns an installation suitable for implementing said method.

The invention relates to a preparation method of end-mercapto polyether, belonging to adhesive field. The deficits of the present preparation method of end-mercapto polyether: the solubleness of product obtained by reacting polyalkylene diol and epoxy halopropane in sodium hydrosulphide is poor and the availability of sodium hydrosulphide is reduced, therefore the difficulty is added to the post-treatment. The chloride polyether, sodium hydrosulphide and alcohol material are mixed together and react for 2-5 hours at boiling point of alcohol material to 40 degree, wherein the quantity relativeratio of alcohol material and sodium hydrosulphide is 3-18:1, the quantity relative ratio of chloride polyether and sodium hydrosulphide is 1:2-3.5. The availability of the sodium hydrosulphide is greatly increased. In addition, the displacement reaction of chloride polyether and sodium hydrosulphide occurs in alcohol material, the reaction temperature is reduced, so as to reduce the energy consumption.