4 results about "Azacyclopropane" patented technology

The invention relates to a preparation method of chiral beta-substituted phenylethylamine and a derivative thereof, which comprises the following step: by taking aziridine as a raw material, nickel salt as a catalyst and a chiral ligand as a ligand and a metal reducing agent, carrying out asymmetric cross electrophilic coupling reaction to prepare the chiral beta-substituted phenylethylamine. The chiral beta-substituted phenylethylamine and the derivative thereof are obtained in one step by adopting a nickel-catalyzed asymmetric electrophilic cross-coupling method, and the method has the advantages of high step economy, high reaction efficiency, less pollutant emission and the like.

This invention relates to the field of coating technology, specifically to a printing coating for colored paper and its preparation method. In the preparation process, this invention incorporates dithiol dihydroxyacetic acid to increase the crosslinking points of the system, and trimethylolpropane tris(2-methyl-1-azacyclopropane propionate) containing an unstable aziridine three-membered ring to improve the degree of crosslinking. It also introduces isoborneol methacrylate to reduce internal stress, effectively balancing the crosslinking density and volume shrinkage of the system, resulting in a coating with excellent adhesion. Furthermore, this invention adds the bifunctional monomer 1,6-hexanediol diacrylate to make the network structure more uniform and provide anti-photooxidation properties, making the system less prone to oxidative discoloration. The addition of tripropylene glycol diacrylate reduces the risk of yellowing caused by small molecule migration. Therefore, the coating obtained in this way has significant anti-yellowing effects, preventing color distortion of colored paper and maintaining the appearance stability of the colored paper.

The invention discloses a method for enantioselective synthesis of NH-aziridine, which comprises the following steps: in the presence of a chiral phosphoric acid catalyst, reacting alpha-cyano heterocyclic conjugated olefin as shown in a formula (I) with N-acyloxyhydroxylamine in an organic solvent to obtain NH-aziridine as shown in a formula (II), according to the present invention, the method can be smoothly performed in the inert organic solvent at the temperature of-40-25 DEG C, the substrate can suitably cover pyridine, quinoline, benzimidazole, benzothiazole, benzoxazole and other N-heteroaromatic rings, the product yield is high, and the enantiomeric excess (ee) can be up to 99%. Inorganic additives (such as magnesium oxide) may be optionally added during the reaction to increase yield on individual substrates without affecting enantioselectivity. The method avoids the traditional multi-step sequence of nitrogen protection first and then deprotection, and has the advantages of economical steps, mild conditions, feasible amplification and the like.

The application discloses a kind of synthesis 13 The application discloses a method for synthesizing C-labeled 4-trifluoromethyl aryl formate and application thereof.The method has mild reaction conditions and simple preparation process.Further, the method uses aryl iodide, epoxide or aziridine as raw materials, and reacts with 13 C-labeled 4-trifluoromethyl aryl formate is used as a starting material, and under the action of a palladium catalyst, a phosphine ligand, a norbornene derivative, a base and an additive, a series of C-labeled isochromane ketone compounds and dihydroisoquinoline ketone compounds can be synthesized by stirring at 60 DEG C in an organic solvent. 13 C-labeled isochromane ketone compounds and dihydroisoquinoline ketone compounds have important theoretical value and application potential.