15 results about "Azacyclopropane" patented technology

The invention discloses a method for simultaneously identifying unsaturated lipid double-bond position isomerization, double-bond cis-trans-configuration and sn-position of a fatty acyl chain where double bonds are located, carbon-carbon double bonds are derived and converted into a product of an aza-ternary ring structure, and double-bond cis-trans isomers and sn-position isomers can be distinguished through liquid chromatography separation. The double-bond position in the double-bond position isomer can be judged through a tandem mass spectrometry method; the related aziridine acylation reaction is simple in reaction condition, fast in reaction and high in yield, and the problem of simultaneous identification of double bond position isomerization, double bond cis-trans isomerization and sn-position isomerization of a fatty acyl chain where double bonds are located of unsaturated lipid can be solved.

The present application relates to the technical field of BOPP film, in particular to a scratch-resistant glue-free matt film and a preparation method thereof, the scratch-resistant glue-free matt film comprises a matt layer, a core layer and a thermal composite layer arranged in sequence, the matt layer comprises copolymerized polypropylene, high-density polyethylene, 2.0-2.5 wt% maleic anhydride modified aziridine as an end group of linear alkyl silicone (weight average molecular weight 120-150 thousand, surface tension 42-45 mN / m) and 2000-4000 ppm spherical polymethyl methacrylate (particle size D50 is 4.0-5.0 microns); the core layer comprises homopolymerized polypropylene; and the thermal composite layer comprises ethylene-vinyl acetate copolymer and 2000-4000 ppm spherical anti-blocking agent. Through the synergistic design of the components of the matt layer and the thermal composite layer, the scratch-resistant glue-free matt film realizes the balance of the surface scratch resistance of the matt layer, the high surface tension (printability) and the smoothness of the winding and unwinding, and provides a solution to the common problem of the scratch resistance of the matt surface for high-end BOPP matt film.

The invention discloses a gram-level synthesis method of Dactyllactone A. The gram-level synthesis method of Dactyllactone A is shown in the description. The method comprises the following steps: with simple and easily available aryl iodide, aziridine and triisopropyl silylacetylene as starting materials, stirring and reacting in an organic solvent at 60-70 DEG C under the action of a palladium catalyst, a phosphine ligand, a norbornene derivative and alkali to obtain a key intermediate; the key intermediate is condensed with iodo gem-dimethyl ester furanone prepared from propiolic acid and dimethyl malonate iodine ylide, and then the condensation product is subjected to an Au / Ag catalyzed intramolecular hydroamination reaction, photocatalytic 6-pi electro-cyclization and two-step conversion, so that the natural product Dactyllactone A can be obtained, wherein the iodo gem-dimethyl ester furanone and iodo gem-dimethyl ester furanone are prepared from propiolic acid and dimethyl malonate iodine ylide. The method has the advantages of cheap and easily available raw materials, short reaction steps, high reaction efficiency, large preparation scale, simple preparation process and the like, has great application potential, and lays a good foundation for industrial production.

The invention relates to a synthesis method of 7H-pyrrolo [2, 3-d] pyrimidine-4-amine, and belongs to the technical field of synthesis of drug intermediates. In order to solve the problems of easy generation of metal residues and low yield in the prior art, the invention provides a synthetic method of 7H-pyrrolo [2, 3-d] pyrimidine-4-amine, which comprises the following steps: in the presence of alkali, reacting aziridine with malononitrile to obtain a compound shown as a formula III; under the action of organic alkali and trichloroisocyanuric acid, the compound shown in the formula III is subjected to oxidative dehydrogenation reaction to be converted into 2-amino-3-cyano-1H-pyrrole; the 2-amino-3-cyano-1H-pyrrole and formamidine acetate are subjected to a reaction, and the 7H-pyrrolo [2, 3-d] pyrimidine-4-amine is obtained. According to the method, the problem of metal residues caused by the adoption of a noble metal catalyst can be effectively avoided, the product yield is better guaranteed, the high-purity quality effect is achieved, and the purity of an intermediate product in each step can reach 99% or above.

The invention relates to a preparation method of chiral beta-substituted phenylethylamine and a derivative thereof, which comprises the following step: by taking aziridine as a raw material, nickel salt as a catalyst and a chiral ligand as a ligand and a metal reducing agent, carrying out asymmetric cross electrophilic coupling reaction to prepare the chiral beta-substituted phenylethylamine. The chiral beta-substituted phenylethylamine and the derivative thereof are obtained in one step by adopting a nickel-catalyzed asymmetric electrophilic cross-coupling method, and the method has the advantages of high step economy, high reaction efficiency, less pollutant emission and the like.

This invention relates to the field of coating technology, specifically to a printing coating for colored paper and its preparation method. In the preparation process, this invention incorporates dithiol dihydroxyacetic acid to increase the crosslinking points of the system, and trimethylolpropane tris(2-methyl-1-azacyclopropane propionate) containing an unstable aziridine three-membered ring to improve the degree of crosslinking. It also introduces isoborneol methacrylate to reduce internal stress, effectively balancing the crosslinking density and volume shrinkage of the system, resulting in a coating with excellent adhesion. Furthermore, this invention adds the bifunctional monomer 1,6-hexanediol diacrylate to make the network structure more uniform and provide anti-photooxidation properties, making the system less prone to oxidative discoloration. The addition of tripropylene glycol diacrylate reduces the risk of yellowing caused by small molecule migration. Therefore, the coating obtained in this way has significant anti-yellowing effects, preventing color distortion of colored paper and maintaining the appearance stability of the colored paper.

The invention provides a bidentate organic tellurium salt catalyst as well as a preparation method and application thereof. The bidentate organic tellurium salt catalyst has a structure as shown in a formula (I). According to the bidentate organic tellurium salt prepared by the invention, the activity of a chalcogenide bond catalyst is improved by introducing an electron-deficient aryl substituent and optimizing a linking group. A series of bidentate organic tellurium catalysts are efficiently developed and have excellent performance in activation of an azetidine structure and an aziridine structure, and it is proved that the chalcogenide bond action capacity of the bidentate organic tellurium catalysts is enhanced. This activation in turn initiates a [4 + 2] cycloaddition reaction with an unactivated olefin or alkyne.

The invention discloses a method for enantioselective synthesis of NH-aziridine, which comprises the following steps: in the presence of a chiral phosphoric acid catalyst, reacting alpha-cyano heterocyclic conjugated olefin as shown in a formula (I) with N-acyloxyhydroxylamine in an organic solvent to obtain NH-aziridine as shown in a formula (II), according to the present invention, the method can be smoothly performed in the inert organic solvent at the temperature of-40-25 DEG C, the substrate can suitably cover pyridine, quinoline, benzimidazole, benzothiazole, benzoxazole and other N-heteroaromatic rings, the product yield is high, and the enantiomeric excess (ee) can be up to 99%. Inorganic additives (such as magnesium oxide) may be optionally added during the reaction to increase yield on individual substrates without affecting enantioselectivity. The method avoids the traditional multi-step sequence of nitrogen protection first and then deprotection, and has the advantages of economical steps, mild conditions, feasible amplification and the like.

The invention provides a chiral bis-imidazoline ligand containing a semi-rigid cyclohexane skeleton structure and a preparation method of the chiral bis-imidazoline ligand. The chiral bis-imidazoline ligand containing the semi-rigid cyclohexane skeleton structure is prepared by taking optically pure transcyclohexane-1, 2-dicarboxylic acid and monosulfonylated 1, 2-diphenylethyl-1, 2-diamine as raw materials. Reaction raw materials are easy to obtain and operation is simple. The product has specific stereoselectivity, can be used for synthesizing a sulfonylated chiral bis-imidazoline ligand with a cyclohexane skeleton structure, and is used for adjusting the coordination capability of the ligand. The synthesized compound is a very important chiral bidentate ligand, and shows a certain chiral control performance in an aziridine propanation reaction of unsaturated ketone.

The present invention relates to the field of medicine and provides a chloroethylnitrosourea compound containing an aromatic group. The chloroethylnitrosourea compound containing an aromatic group has the following general structural formula: #imgabs0# wherein R is selected from -CH3, -CH2CH3, or #imgabs1#, and Ar is selected from benzene, substituted benzene, #imgabs2#, or #imgabs3#. The chloroethylnitrosourea compound containing an aromatic group of the present invention has a higher ability to penetrate the brain barrier, fully utilizes the effect of the aziridine ion, and has excellent anti-glioma cell activity, and also exhibits anti-tumor cell activity against various tumors.

The invention belongs to the technical field of organic chemical synthesis, and particularly relates to an ethyl-# imgabs0 # base derivative as well as a preparation method and application thereof. The ethyl-# imgabs1 # base derivative provided by the invention is a compound with a structure as shown in a formula I: # imgabs2 #. The compound provided by the invention is an enantiomer-pure ethyl-# imgabs3 # base compound, has a nitrogen chiral center and a unique rigid structure, and can be used for preparing a compound with a nitrogen chiral center. And a material structure basis can be provided for molecular recognition, supramolecular chemistry, asymmetric catalysis and discovery of novel drug molecules. Particularly, the compound provided by the invention can be used as a chiral catalyst to catalyze aziridine propanation reaction of chalcone, and the whole reaction condition is mild, the yield is moderate, the enantioselectivity is moderate, and the compound is suitable for being used as the chiral catalyst.

The application discloses a kind of synthesis 13 The application discloses a method for synthesizing C-labeled 4-trifluoromethyl aryl formate and application thereof.The method has mild reaction conditions and simple preparation process.Further, the method uses aryl iodide, epoxide or aziridine as raw materials, and reacts with 13 C-labeled 4-trifluoromethyl aryl formate is used as a starting material, and under the action of a palladium catalyst, a phosphine ligand, a norbornene derivative, a base and an additive, a series of C-labeled isochromane ketone compounds and dihydroisoquinoline ketone compounds can be synthesized by stirring at 60 DEG C in an organic solvent. 13 C-labeled isochromane ketone compounds and dihydroisoquinoline ketone compounds have important theoretical value and application potential.

This invention belongs to the field of organic chemical synthesis technology, specifically relating to an ethyl-base derivative, its preparation method, and its applications. The ethyl-base derivative provided by this invention is a compound with the structure shown in Formula I. The above-mentioned compound provided by this invention is an enantiomeric pure ethyl-base compound, possessing a nitrogen chiral center and a unique rigid structure, which can provide a structural basis for molecular recognition, supramolecular chemistry, asymmetric catalysis, and the discovery of novel drug molecules. In particular, the compound of this invention can serve as a chiral catalyst for the azahexacyclopropanation reaction of chalcones, with mild reaction conditions, moderate yield, and moderate enantioselectivity, making it suitable for application as a chiral catalyst.

The invention belongs to the technical field of nanofiltration membrane materials, and specifically relates to a method for preparing a positively charged nanofiltration membrane for efficiently removing uranium and samarium from radioactive wastewater. According to the Donnan charge effect of the nanofiltration membrane, a positively charged branched polyaziridine is used as an aqueous phase monomer, and trimesoyl chloride is used as an organic phase monomer, and an interfacial polymerization method is adopted to prepare the positively charged nanofiltration membrane. Then, multi-walled carbon nanotubes are modified by ultrasound-assisted tannic acid, and tannic acid rich in hydrophilic OH can be wrapped on the surface of multi-walled carbon nanotubes, thereby improving the dispersibility and hydrophilicity of multi-walled carbon nanotubes in water, and adding the multi-walled carbon nanotubes to an aqueous phase solution, and the interfacial polymerization reaction process is regulated by using the unique nanopores and rich oxygen-containing functional groups of the tannic acid-modified multi-walled carbon nanotubes, the thickness of the separation layer is reduced, the roughness of the membrane surface is reduced, and the hydrophilicity of the membrane surface is improved, thereby improving the water flux and the retention rate of the positively charged nanofiltration membrane, and preparing a high-throughput positively charged nanofiltration membrane suitable for radioactive wastewater treatment.

The invention discloses a preparation method of tetrahydro-gamma-carboline, and belongs to the field of organic synthesis. According to the method, 3-iodo-indole with indole N-H protected by p-toluenesulfonyl, aziridine and olefin are used as initial raw materials and stirred to react in an organic solvent at the temperature of 80-110 DEG C under the action of a palladium catalyst, norbornene, a phosphine ligand and alkali, and the 4-substituted tetrahydro-gamma-carboline derivative can be obtained. The raw materials used in the method are cheap and easy to obtain, the reaction process is mild, the substrate universality is good, the 4-substituted tetrahydro-gamma-carboline derivative can be obtained through one-step reaction, the method has high step economy and practicability, and a convenient and feasible path is opened up for synthesis of the 4-substituted tetrahydro-gamma-carboline derivative.