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Gastrointestinal tract controlled release type probiotic bead

A technology of probiotics and gastrointestinal tract, applied in the field of probiotics, can solve the problems of inability to colonize the intestines, large pores of hydrogel beads, and low survival rate, so as to increase the concentration of effective probiotics and improve the intestinal flora , the effect of inhibiting digestion

Pending Publication Date: 2021-12-24
江西省华宝芯荟科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] As shown above, on the one hand, the currently disclosed prior art lacks probiotic products that focus on targeted delivery of the gastrointestinal tract; on the other hand, the preparation process is complicated and further processing is required before consumption
In addition, there are still technical problems such as single product form, low survival rate, inability to colonize the intestinal tract, inability to wrap a solid oil phase protective shell on the outer layer of the mobile oil phase, and large pores of the hydrogel beads, which cannot be delivered to the intestinal tract.

Method used

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  • Gastrointestinal tract controlled release type probiotic bead
  • Gastrointestinal tract controlled release type probiotic bead
  • Gastrointestinal tract controlled release type probiotic bead

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Embodiment 1: A kind of gastrointestinal tract controlled-release probiotic beads

[0065] Probiotic beads sample preparation: Weigh 15 parts of gelatin with 250 freezing force, 2 parts of pectin, 3 parts of chitosan, 12 parts of whey protein isolate, 60 parts of distilled water, and continuously stir and dissolve in a water bath at 60 °C for 3 hours. After complete dissolution, keep it warm to remove air bubbles. Weigh 3 parts of mono-diglyceride fatty acid esters, 1.5 parts of sodium bicarbonate, 1.5 parts of citric acid, 7 parts of stearic acid and dissolve them in 95 parts of canola oil, heat at 60°C for 30 minutes to dissolve completely, then cool to 30-37°C , add 6 parts of Lactobacillus plantarum powder, and disperse for 3 minutes with a disperser at 5000rpm to make a uniform fluid suspension oil phase. Weigh 92 parts of stearic acid, 8 parts of silicon dioxide, 10 parts of isomaltooligosaccharide, and 8 parts of extracellular polysaccharide, heat them in a 75°C...

Embodiment 2

[0082] Embodiment 2: A kind of gastrointestinal tract controlled-release probiotic beads

[0083] The preparation method is as follows:

[0084] (1) Preparation of mobile bacterial oil phase

[0085] Add 91 parts of sunflower oil, 4 parts of glyceryl monostearate, 1 part of sodium bicarbonate, 1 part of tartaric acid, and 6 parts of high-melting point palm oil in proportion, stir evenly, heat at 60°C for 30 minutes to dissolve completely, and then cool to room temperature. Add 4 parts of Lactobacillus rhamnosus bacteria powder in proportion, and disperse for 2 minutes at 6000rpm in a disperser to make a uniform fluid suspension oil phase;

[0086] (2) Preparation of solid lipid protective layer

[0087] Add 95 parts of sitosterol, 8 parts of calcium silicate, 10 parts of extracellular polysaccharides, and 12 parts of galacto-oligosaccharides in proportion, stir in a 70°C water bath for 25 minutes to melt, and keep warm in the molten state for use;

[0088] (3) Preparation o...

Embodiment 3

[0094] Embodiment 3: A kind of gastrointestinal tract controlled-release probiotic beads

[0095] The preparation method is as follows:

[0096] (1) Preparation of mobile bacterial oil phase

[0097] Add 96 parts of canola oil, 6 parts of glyceryl distearate, 1 part of sodium carbonate, 1 part of tartaric acid, and 5 parts of beeswax in proportion, stir well, heat at 60°C for 30 minutes to completely dissolve, cool to room temperature, and add in proportion 8 parts of bifidobacteria powder were dispersed by a disperser at 8000rpm for 2 minutes to make a uniform fluid suspension oil phase;

[0098] (2) Preparation of solid lipid protective layer

[0099] Add 93 parts of shortening, 10 parts of silicon dioxide, 12 parts of extracellular polysaccharides, and 15 parts of galacto-oligosaccharides in proportion, stir in a water bath at 80°C for 30 minutes to melt, and keep warm in the molten state for use;

[0100] (3) Preparation of rubber phase

[0101] Add 3 parts of shellac,...

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Abstract

The invention belongs to the technical field of food, and particularly relates to a gastrointestinal tract controlled release type probiotic bead. The probiotic bead comprises a flowing state oil phase with dispersed bacteria, a solid lipid protection layer and a gel phase; a supercooling medium is released in the dropping process of the probiotic bead, so that the molten solid fat is instantly cooled to form a solid lipid protection layer on the outer layer of the flowing state oil phase; solid particles such as silicon dioxide are added into the solid lipid protection layer, so that holes in the gel phase can be supplemented in time when a large number of hole structures are generated by enzymolysis in the intestinal digestive tract, and the structural integrity of the probiotic bead is kept; and in the gel phase, a condensation-induced network gel technology is adopted, and whey protein isolate gel is induced by edible ethanol, so that the gel phase with a more compact structure can be formed. The probiotic bead enriches the form of probiotic products, realizes high entrapment efficiency of the probiotics and high survival rate of gastrointestinal tracts, and delivers the probiotics to the colon to complete intestinal colonization.

Description

Technical field: [0001] The invention belongs to the technical field of probiotics, and in particular relates to a probiotic bead for controlled release in the gastrointestinal tract prepared by combining a solid lipid protective layer and a double network gel rubber skin layer. Background technique: [0002] Probiotics widely exist in the intestinal tract of the human body, and long-term use can regulate the microecological flora of the gastrointestinal tract and maintain the balance of the microecology; It loses its activity in oxygen, and it is difficult to realize its physiological effects. The probiotic beads in the prior art are basically cross-linked by calcium chloride and sodium alginate to prepare calcium chloride and sodium alginate cross-linked probiotic beads. The probiotic beads formed by this method have large gel holes, and gastric acid will Probiotics can be damaged through the pores; powders and chewable tablets are dispersed in water or chewed to take pro...

Claims

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Application Information

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IPC IPC(8): A23L33/135A23L29/231A23L29/256A23L29/25A23L29/244A23L29/00A23L29/30A23L29/281A23L29/275A23L29/20A23P10/30A23P20/20
CPCA23L33/135A23L29/231A23L29/256A23L29/25A23L29/244A23L29/03A23L29/30A23L29/281A23L29/284A23L29/275A23L29/20A23P10/30A23P20/20A23V2002/00A23V2400/125A23V2400/113A23V2400/175A23V2400/51A23V2400/169A23V2200/3204A23V2250/5432A23V2250/5072A23V2250/511A23V2250/54252A23V2250/182A23V2250/192A23V2250/1576A23V2250/1614A23V2250/032A23V2250/1886A23V2250/18A23V2250/1628A23V2250/284A23V2250/51A23V2250/1944A23V2250/082A23V2200/228A23V2250/056A23V2250/21372A23V2250/1578A23V2250/5026A23V2250/5028Y02A50/30
Inventor 孙文轩邹立强高洪霞刘伟
Owner 江西省华宝芯荟科技有限公司
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