Intestinal mucosa protection and restoration type enteral nutritive product and preparation method thereof

A product and nutrition technology, applied in food preparation, bacteria used in food preparation, food ingredients, etc., can solve problems such as the inability to balance efficacy and nutrition, single function of chemical drugs, and complex ingredients of traditional Chinese medicine prescriptions, etc., to achieve enhancement and promotion Intestinal mucosal repair effect, reduce endotoxin translocation, and promote intestinal peristalsis

Active Publication Date: 2014-02-05
SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The chemical drugs or traditional Chinese medicine prescriptions used in the above measures all have certain deficiencies: the functions of chemical drugs are relatively single, and the efficacy and nutrition cannot be taken into account at the same time.
For patients who have experienced major trauma, major surgical operations, and tumor patients undergoing radiotherapy and chemotherapy, the patent aims at strengthening and repairing the intestinal mucosa, and its components and functions are relatively simple
The composition of traditional Chinese medicine preparations is complex, the treatment process is longer, and the onset of effect is slower

Method used

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  • Intestinal mucosa protection and restoration type enteral nutritive product and preparation method thereof
  • Intestinal mucosa protection and restoration type enteral nutritive product and preparation method thereof
  • Intestinal mucosa protection and restoration type enteral nutritive product and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Raw materials that meet the relevant national edible standards are fresh oysters cultured in sea water. The materials are obtained by washing, shelling and viscera removal, adding 1:3 pure water according to the weight to volume ratio, and mixing until homogeneous. According to the weight of the material, add 1% trypsin, adjust the pH, keep the temperature at 40°C, and perform enzymatic hydrolysis for 7 hours. Centrifuge to remove the precipitate, and the supernatant is passed through an ultrafiltration membrane to obtain a peptide solution below 5000 Da, and then concentrated in a vacuum to obtain a small molecule peptide solution separated by enzymatic hydrolysis of oysters.

[0074] Take 2.0 parts of marine animal enzymatic hydrolysis and separation of small molecule peptide liquid (dry weight basis), 15.0 parts of soybean peptide, 4.0 parts of medium and long-chain fatty acid edible oil, 76 parts of maltodextrin, 2.0 parts of polydextrose, 0.5 part of stachyose, Ala ...

Embodiment 2

[0078] Raw materials that meet the relevant national edible standards are fresh octopus cultured in sea water, cleaned and removed from the viscera to obtain materials, added 1:3 purified water according to the weight-to-volume ratio, and crushed to homogenize. According to the weight of the material, add 3% pepsin, adjust the pH, keep the temperature at 40°C, and perform enzymatic hydrolysis for 6 hours. Centrifuge to remove the precipitate, and the supernatant is passed through an ultrafiltration membrane to obtain a peptide solution below 5000 Da, and then concentrated in a vacuum to obtain a small molecule peptide solution separated by enzymatic hydrolysis of octopus.

[0079] Take 10.0 parts of octopus enzymatic hydrolysis and separation of small molecule peptide liquid (dry weight basis), 15.0 parts of soybean peptide, 10.0 parts of medium and long-chain fatty acid edible oil, 43 parts of maltodextrin, 10.0 parts of soybean dietary fiber, 3.0 parts of raffinose, Arg- 9.0...

Embodiment 3

[0083] Raw materials that meet the relevant national edible standards are fresh cobia cultured in sea water, cleaned, scaled and viscerated to obtain materials, and purified water of 1:3 is added according to the weight-to-volume ratio, and crushed and homogenized. According to the weight of the material, add 2% papain, adjust the pH, keep the temperature at 50°C, and perform enzymatic hydrolysis for 8 hours. Centrifuge to remove the precipitate, and the supernatant is passed through an ultrafiltration membrane to obtain a peptide solution below 5000 Da, and then concentrated in a vacuum to obtain a cobia enzymatic hydrolysis and separation of small molecules.

[0084] Take cobia enzymatic hydrolysis and separation of small molecule peptide liquid 10.0 parts (dry weight basis), soybean peptide 5.0 parts, medium and long-chain fatty acid edible oil 4.0 parts, maltodextrin 78.0 parts, soybean dietary fiber 2.0 parts, fructooligosaccharides 0.5 parts, Gly -0.5 part of Gln, and fa...

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Abstract

The invention belongs to a nutritive food production field, concretely an intestinal mucosa protection and restoration type enteral nutritive product and a preparation technology thereof, and provides a product capable of protecting intestinal mucosa, promoting restoration of the intestinal mucosa after injury, preventing and mitigating patient constipation, and providing equalization nutrition support. The nutritive product is prepared from micromolecule peptides of sea animals, glutamine dipeptide, soybean peptide, maltodextrin, dietary fiber, and medium- and long-chain triacylglycerol oil, etc., is blended with composite vitamins, prebiotics and probiotics according to nitrogen and heat requirements recommended to medium stress patients, can protect the intestinal mucosa and promote restoration of the intestinal mucosa, and promotes intestinal colonization of beneficial bacteria, thereby inhibiting harmful bacteria proliferation, reducing endotoxin generation, preventing movement of endotoxin, and providing a nitrogen source, carbohydrate, fat and vitamins required by a human body in a pathologic period. The product is suitable for a patient with intestinal mucosa injury caused by a plurality of factors like wound, great surgery operation and tumour chemotherapy, is safe and has no toxic side effect, and can be prepared to be electuary or functional nutritive injectable suspension.

Description

technical field [0001] The invention belongs to the field of nutritional food production, and in particular relates to a functional nutritional product for intestinal mucosa protection and repair and a preparation process thereof. Background technique [0002] The audience of this nutritional product is patients with major trauma, patients who need nutritional enhancement before surgery and nutritional support after surgery, and cancer patients during radiotherapy and chemotherapy. [0003] After the human body suffers major trauma, shock, and major surgical operations, the body is in a state of stress, and the body functions will preferentially distribute blood to important organs such as the heart and brain. recover. Intestinal blood flow hypoperfusion or hypoxia slows down normal intestinal peristalsis, causes bacterial flora imbalance, causes pathogenic bacteria to proliferate, releases bacterial proteases and lipopolysaccharide (LPS)-based endotoxins, and directly dama...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A23L33/00
CPCA23L33/40A23V2002/00A23V2400/123A23V2400/533A23V2200/32A23V2250/55A23V2250/5114A23V2250/5042A23V2250/632A23V2250/70A23V2250/5116A23V2250/622A23V2250/28
Inventor 潘剑宇孙恢礼陈华蔡冰娜
Owner SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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