992 results about "Youngest child" patented technology

An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.

An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Methods for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 19A polysaccharide are also provided in which the serotype 19A polysaccharide is co-lyophilized with a carrier protein and conjugation is carried out in dimethyl sulfoxide (DMSO) via a reductive amination mechanism.

An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Also described is a method for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 1 polysaccharide covalently linked to a carrier protein, the method including partial de-O-acetylation of the polysaccharide by mild hydrolysis in an alkaline pH buffer.

An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Also described is a method for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 3 polysaccharide covalently linked to a carrier protein, the method including periodic acid oxidation of the polysaccharide in the presence of bivalent cations.

An oral pacifier apparatus is disclosed for use by infants and young children to promote soothing oral stimulation and for administering fluids and liquid medications. The pacifier apparatus includes a nipple, a shield, a removable access assembly, and a detachable, refillable reservoir. Furthermore, the nipple includes a linear array of nipple holes which directs fluid flow to physiologic gutters adjacent to the tongue of the user, thereby avoiding stimulating the gag reflex. The method of using the pacifier apparatus to treat dehydration is also disclosed.

A device for feeding a young child without the threat of choking, this device comprising a handle member in combination with an elongate food-receiving mesh container having an aperture in one end thereof. A ring component too large to swallow is mounted in the aperture. One end of the handle member has a circularly disposed sealing surface, and having a securing member around its adjacent exterior surface. A closure ring having a securing member around its interior surface is able to interfit with the securing member of the handle end. The closure ring has a central aperture of a size to closely receive the container, but not permitting the passage of the ring component. When the closure ring has been tightened upon the handle end, the ring component will tightly engage the circularly disposed sealing surface on the handle, holding the container in an operative position.

A method for alerting a driver of an automotive vehicle (or other responsible party) to the presence or inferred presence of an object, a person, or a pet animal in rear seating rows of the vehicle. The open / closed condition of rear vehicle doors is monitored to determine whether the driver may have placed an object, child, or pet in the rear seating rows prior to the start of a drive-cycle, and an alert is generated at the end of the drive-cycle to remind the driver to check the rear seat. Sound detection and analysis may also be used to identify sounds characteristic of a human (a young child, for example) or a non-human animal (a pet, for example) and thereby verify that a child or pet is present.

A toothbrush device used for a unique teaching method for proper teeth brushing techniques by means of prerecorded audio commands emanating from the handle of the toothbrush. The toothbrush with audio is a product that is designed to easily and quickly provide a new and unique motivation for young children to brush their teeth correctly. This special toothbrush combined with an integral audio device to encourage and coach children on proper tooth brushing habits. The configuration comprises a handle that is slightly larger than a conventional toothbrush and the handle contains a waterproof speaker, a power switch, and a battery compartment. The extension neck and bristle are similar to conventional toothbrushes.

The present invention provides a multivalent immunogenic composition having 15 distinct polysaccharide-protein conjugates. Each conjugate consists of a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F or 33F) conjugated to a carrier protein, preferably CRM197. The immunogenic composition, preferably formulated as a vaccine on an aluminum-based adjuvant, provides broad coverage against pneumococcal disease, particularly in infants and young children.

A toothbrush assembly with a sound generating function for providing excitement and entertainment to a user and for encouraging a young child to brush his or her teeth is provided. The toothbrush assembly has a contact-type switch and a sound generator. The contact-type switch has a swingable contact and generates a pulse when a power switch of the assembly is instantaneously closed for every swing of the swingable contact according to the tooth-brushing movement of a user. The sound generator has a counter for counting pulses from the contact-type switch and a sound recording and play back unit for generating a voice message or musical tone when the sum of the pulses counted by the counter reaches a predetermined value. The sound recording and play back unit of the sound generator outputs different voice messages or musical tones according to different predetermined values reached by the sum of the pulses counted by the counter.

A breathing mask for use in administering inhalable medications to a patient in need of an inhaled drug is provided. The mask disclosed herein is particularly useful for use with very young children. The mask is made from a flexible molded plastic silicone or elastomeric material, and has an anthropometrically / anatomically / ergonomically contoured shape to provide a good seal, a comfortable fit, and minimal dead space within the mask. The airway is aligned with nose. There may be an orifice for use with a soother device to calm a child using the mask. Also provided is a visual flow indicator to provide an indication of the quality of the seal of the mask on the face.

An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Also described is a method for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 3 polysaccharide covalently linked to a carrier protein, the method including periodic acid oxidation of the polysaccharide in the presence of bivalent cations.

An apparatus is provided for simulating and monitoring a respiration pattern of a human. The apparatus generally includes a reservoir having an outlet, and actuator disposed in the reservoir for moving fluid in and out of the reservoir, and a control unit coupled to the actuator for controlling the actuator to simulate and monitor a respiration pattern of a human. Also, a method is provided for simulating and monitoring a respiration pattern of a human. The method includes steps of generating a waveform defining the respiration pattern and controlling an actuator to move fluid in and out of a reservoir based on the waveform. The apparatus and method can accurately simulate and monitor a respiration pattern of a human, especially an infant and a young child, and offer a flexibility to stimulate variety of respiration patterns.

A safe-media interaction system includes distinct child and parent interfaces through which a child can interact with content and applications that are selected and authorized by a parent through the parent interface. The child interface allows a young child who has not yet acquired any reading skills, verbal skills, or visual organization skills to select a content item or application feature from a selection of such items / features visually presented to the child and interact with the selected item / feature through a general purpose computer interface such as a touch screen or keyboard with labels placed over selected keys. The safe-media interaction system also supports special purpose interfaces such as remote controls, kid-safe toys, and a dance pad to facilitate early childhood use of the system.

The invention relates to an apparatus for monitoring the body temperature of a subject and to provide an alert locally or remotely to a third party if the bodily temperature of the subject is determined to be abnormal. The device preferably employs infra-red (IR) radiation to remotely measure the temperature of the subject without contact with the subject's skin. The alert system is preferably configured to transmit an alert to a selected third party via a conventional telephone line (plain ordinary telephone service or POTS) or through a wireless mobile communication system. The subjects in the preferred embodiment are infants and young children, seniors, invalids and others who are otherwise confined to a circumscribed area for health reasons.

Remotely detecting the presence of urine or feces in a diaper of an infant or adult using a disposable sensor placed inside the diaper, in conjunction with a permanent device that is capable of wirelessly transmitting data to a mobile device or base station is disclosed. The permanent device can also be capable of measuring temperature and body movements. This additional information can be used in conjunction with the detection of urine or feces to identify patterns.

Absorbent articles incorporating sensory element members are disclosed. The absorbent articles may be disposable pant like garments designed to assist urinary toilet training such as of young children. Upon urination by the wearer, the article produces a feedback response which is transmitted to the wearer by the sensory element member. Wetness based, temperature based and other feedback responses are disclosed. The feedback response should be immediate and unmistakable to the wearer and also be temporary and harmless.

The formula of the invention, intended both for infants and young children, comprises at least one LC-PUFA and at least one probiotic. The invention also pertains to methods of strengthening natural immune defences and promoting a healthy mental development in infants or young children by fully or partly feeding them with the said formula.

The nonlinear complexity of EEG signals is believed to reflect the scale-free architecture of the neural networks in the brain. Analysis of the complexity and synchronization of EEG signals as described herein provides a quantitative measure for routine monitoring of functional brain development in infants and young children and provide a useful biomarker for detecting functional abnormalities in the brain before the cognitive, behavioral or social manifestations of these brain developments can be observed and measured by standard tests. One or more machine learning algorithms are used to discover relevant patterns in the complexity and synchronization values determined from the EEG data to facilitate risk assessment and / or diagnosis of developmental disorders in infants and young children by predicting cognitive, behavioral and social outcomes of the measured functional brain activity patterns.

A rod and connector toy construction set, especially for use by young children. Connector elements, are formed with one or more rod-gripping sockets arranged radially with respect to a hub. The sockets are open at opposite sides, enabling lateral insertion and removal of rods. The connector elements, which are relatively large for easy handling by small children, are formed of a soft and pliant plastic material, to facilitate assembly and disassembly of rods with the connector elements by small hands. The rods generally are formed of a plastic material harder and stiffer than the connector material to accommodate easy handling of the rods during assembly and disassembly and to provide adequate strength in an assembled structure. The rods include enlarged, generally cylindrical end portions and adjacent neck portions of reduced diameter. The connector sockets include inner portions, configured to receive and closely confine the rod end portions, and outer portions arranged to receive and snuggly grip the rod neck portions, such that rods are held in axial alignment with the connector sockets.

A connector assembly for use in securely joining together elongated structural members, which extend angularly with respect to one another. The connector assembly is ideally suited for use in interconnecting wooden structural members that make up playground equipment for use by young children and includes specially designed connector plates that are uniquely designed to provide both longitudinal and transverse stability to the structure formed by the interconnected structural members. Each of the gripping plates is lanced out to form a plurality of penetrating tabs that are adapted to penetrate the structural members as the gripping plates are cinched down by through bolts so as to provide still further rigidity to the assembled structure.

This invention relates to novel human monoclonal antibodies (mAbs) and to the genes encoding same. More specifically, this invention relates to human monoclonal antibodies specifically reactive with an epitope of the fusion (F) protein of Respiratory Syncytial Virus (RSV). Such antibodies are useful for the therapeutic and / or prophylactic treatment of RSV infection in human patients, particularly infants and young children.

The concept herein is focused on an apparatus centered on a sand and water table, as used by young children for play and educational purposes, such sand and water table comprising an upright table having a depressed container area, which is open at the top for access from above with an upper table perimeter portion around the upper edge of the depressed container area, into which table perimeter portion is formed a recessed channel area that has dual functions, one being to help prevent spillage of sand, water, or other substances from the depressed container area, with the additional concept including an interior lining member that is adapted to fit conformingly into the open depressed container area, with the liner having an upper opening edge which opening edge is provided with an outwardly extending flat ledge adapted to rest on an inner portion of the perimeter portion of such table with an outer partially looped portion affixed to the outer perimeter of the flat ledge of the liner, which partially looped portion is adapted to fit conformingly over the most outer part of the table perimeter portion.

A device for safely retaining an object such as a child's bottle or other object consisting of interrelated straps of webbing or other materials employing tensionally locked slidably compression buckles. One or all of the straps are adjustable for length. The attachment and retention straps are placed circumferentially around the objects to be attached. The strap engaging the bottle or other component is best compressively engaged and employs buckles having a tensional release and dexterity requirement lacking in young children.

Systems and methods for measuring and improving a young child's mental abilities on a tablet computer. A user of the tablet computer is prompted for the child's age and, based on the age, the expected performance or abilities of the child are provided. The child can be assessed using a number of activities whereby the child identifies and / or matches various objects. The assessment can be done by timing the activity to completion, determining how many errors / tries were needed to complete the activity, or any other number of assessment techniques. The child's performance is then compared against expected metrics for children of a similar age. The activities can range from games that involve identifying everyday objects to the introduction of mathematical concepts and numbers to identifying and / or matching animals.

A system and method for automated crowd sensing object detection. The invention senses a missing object's presence in proximity which is conducted using a smartphone, with a software application running in the background that opportunistically collects and reports the data without the active involvement of the user. A small tag is attached to a tracked object or worn by a person who does not carry a smartphone (i.e., a young child), and emits a secure wireless signal periodically for geo-fencing and geo-tracking by caregivers. The information is sent to a cloud server so that the commander may be able to confirm the whereabouts of the tagged object or person in this case.

A temperature-sensitive vehicle occupancy detection and alert system. The system alerts users when a young child is left unattended in a vehicle in order to prevent the young child from being exposed to dangerously high or low temperatures within the interior of the vehicle. The system utilizes sensor data captured by a plurality of different sensors, including at least one occupancy sensor, at least one temperature sensor, and at least one distance sensor. The system applies logic to the captured sensor data to determine whether to alert a user as to the fact that an occupant has been left unattended and to control various functions of the automobile that would allow individuals external to the vehicle to rescue the occupant from the dangerous conditions or provide relief to the child from the conditions, including by unlocking the vehicle's doors, lowering the vehicle's windows, and / or activating the vehicle's temperature control system.