The invention provides a marker combination, a combined
reagent and a kit for early
risk assessment of caries of young children and application of the marker combination, the combined
reagent and the kit in construction of an early
risk assessment model of caries of young children, and belongs to the technical field of oral preventive
medicine and oral
public health.
Saliva samples of the young children are researched by adopting
proteomics and metabonomics, and 2-oxoadipic acid, enoyl
coenzyme A hydratase and kynurenase can be used as a marker combination for evaluating early caries risk of the young children. According to the abundance reference indexes of 2-oxoadipic acid, enoyl
coenzyme A hydratase and kynureninase, an early
risk assessment model for the caries of the low-age children is constructed. The early risk assessment model for the caries of the young children, which is constructed by the method disclosed by the invention, has relatively good stability, sensitivity and specificity, and lays a
solid foundation for taking effective
intervention measures to realize comprehensive prevention and control of caries.